Navigation Links
Rong Li Lab probes mechanism of asymmetry in meiotic cell division
Date:10/7/2008

The Stowers Institute's Rong Li Lab has characterized a mechanism that allows for asymmetrical cell division during meiosis in oocytes. By tracking chromosome movement in live mouse oocytes, the team discovered that chromosomes can recruit to their vicinity a protein called formin-2. This protein allows the oocyte to retain the majority of the cytoplasm a requirement for embryonic development after fertilization while the other daughter cell (called a polar body) resulting from the asymmetric division gets only a minimal amount and subsequently dies.

The work was published this week in the advance online publication of Nature Cell Biology.

Formin-2 is an actin-nucleating protein that can promote the formation of actin filaments around the chromosomes. Actin filaments undergo dynamic elongation and shortening and, in the process, push the chromosomes towards the outer edge of the oocyte. After the chromosomes reach the periphery, the actin filaments orient the cell division plane so that most of the cytoplasm required to sustain the earliest stages of development stays with the daughter cell that retains the identy of the oocyte.

"This work revealed the general mechanism by which the actin cytoskeleton drives chromosome movement in mammalian meiotic oocytes," said Hongbin Li, Ph.D., Senior Research Associate and lead author on the publication. "Our findings will enable us to carry out even more detailed dissection of the molecular components and mechanisms."

"Infertility and birth defects are often related to problems during oocyte meiotic cell divisions," said Rong Li, Ph.D., Investigator and senior author on the paper. "Failure in the chromosome movement will lead to failed oocyte maturation and infertility. These findings provide an important step toward a better understanding of the process of meiotic divisions and how actin generates the force to power intra-cellular movements."


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1

Related biology news :

1. Comet probes reveal evidence of origin of life, scientists claim
2. Studying component parts of living cells with carbon nanotube cellular probes
3. New MIT tool probes brain circuits
4. Astronomy technology brings nanoparticle probes into sharper focus
5. Team probes mysteries of oceanic bacteria
6. ESF conference probes waters mysterious interactions at molecular level
7. Fast AFM probes measure multiple properties of biomolecules or materials simultaneously
8. Broad Institute awarded grant to develop chemical probes for human biology and disease
9. National Science Foundation grants Clemson professors award to develop nanoprobes
10. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
11. Scientists find clue to mechanisms of gene signaling and regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... Calif. , April 13, 2017 UBM,s ... York will feature emerging and evolving technology ... Both Innovation Summits will run alongside the expo portion ... speaker sessions, panels and demonstrations focused on trending topics ... largest advanced design and manufacturing event will take place ...
(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... September 20, 2017 , ... RoviSys, a leading ... today the opening of an office in Taipei, Taiwan. This new location allows ... while developing new relationships in the region. Located in the Neihu area of ...
(Date:9/19/2017)... ... September 19, 2017 , ... Participants of this educational webinar ... hood. Along with the advantages and disadvantages of ductless, filtered fume hoods, they ... the laboratory. , Attendees will learn from an industry expert about the different ...
(Date:9/19/2017)... ... September 19, 2017 , ... VetStem Biopharma ’s CEO and founder, Dr. Bob ... in Riordan’s new book "Stem Cell Therapy: A Rising Tide". Dr. Harman and Dr. ... They bonded over an interest in the potential of stem cell therapy and a fast ...
(Date:9/19/2017)... ... September 19, 2017 , ... One of the ... be eliminated, said Lyle Probst, President, CEO and Founder of ExcitePCR ™. ... other pathogen detection solutions, Probst said, “Sample preparation takes place inside our FireflyDX ...
Breaking Biology Technology: