Navigation Links
Rong Li Lab offers insight into adaptive ability of cells
Date:11/26/2008

The Stowers Institute's Rong Li Lab has published findings that shed light on the ability of cells to adapt to disruptions to their basic division machineries findings that may help explain how cancer cells elude the body's natural defense mechanisms or chemotherapy treatment. The work was published in the November 26 issue of Cell.

Working with yeast cells, the team disabled a motor protein, type II myosin which normally powers cell division and observed the cellular response. As predicted, blocking division initially resulted in severe growth and cytokinesis defects. But after several selection passages, some cells were able to solve the problems. Unexpectedly, these cells ended up with more than the normal number of chromosomes. The abnormal chromosome numbers led to changes in the patterns of gene expression, which correlated with the cells' ability to evolve new ways to complete division and resume growth.

"The ability of cellular systems to evolve is linked to their component and network complexity, which allows the cell to develop 'workarounds' to salvage normal functions, even in times of crisis," said Giulia Rancati, Ph.D., Postdoctoral Research Associate and co-equal lead author on the paper. "Surprisingly, the adaptation was accomplished not by changes in DNA sequences but largely by modifying the number of chromosomes in the cell (known as aneuploidy), which were passed on to future generations."

"Another process that contributed to the successful adaptation involved polyploidization, in which yeast cells multiplied their entire set of chromosomes," said Norman Pavelka, Ph.D., Postdoctoral Research Associate and co-equal lead author on the paper. "Aneuploidy and polyploidy are hallmarks of cancer, and these findings suggest that they may contribute directly to the ability of cancer cells to evolve, allowing them to multiply, even as the body's natural mechanisms for cellular regulation or chemotherapeutic drug treatment work to limit their growth."

The work establishes an exciting new path for the Rong Li Lab.

"These findings validated our view that evolvability is a trackable and important subject for study," said Rong Li, Ph.D., Investigator and senior author on the paper. "We are now working to determine whether there are many distinct mechanisms of evolvability correlating with varying types and degrees of cellular disruptions. Additionally, we would like to explore the possibility of predicting the likely evolutionary paths and outcomes based on the architecture of molecular networks present in the cell; and in extending our research into mammalian cell systems to directly study the role of aneuploidy in the evolution of cancer."


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. New partnership offers outsourced R&D in membrane biology
2. Census of protein architectures offers new view of history of life
3. NAS report offers new tools to assess health risks from chemicals
4. New class of drug offers hope to treatment-resistant AIDS patients
5. Darwin Symposium at Field Museum offers broad overview of his science and its impact
6. Conference on healthspan offers new opportunities for interdisciplinary collaboration
7. Protein controls blood vessel formation, offers new drug target
8. Genetic breakthrough offers promise in tackling kidney tumors
9. New research offers prioritization plan for reducing nutrient pollution in feeder streams
10. Intellifit(R) Offers Custom-Made Jeans with a High-Tech Twist
11. New dinosaur from Mexico offers insights into ancient life on West America
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
(Date:3/18/2016)... LONDON , March 18, 2016 ... Established Suppliers of Biometrics, ICT, Manned & Unmanned Vehicles, Physical ... & security companies in the border security market and ... and Europe has led ... your companies improved success. --> defence & ...
(Date:3/14/2016)... 2016 NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ... March 21 st .  The commercials will air on Bloomberg ... on the Street show. --> NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... -- At present, the Biotech sphere is in ... that volatility is what makes this industry interesting to consider. ... Corp. (NASDAQ: SNTA ), CTI BioPharma Corp. (NASDAQ: ... ), and Heat Biologics Inc. (NASDAQ: HTBX ). ... for these stocks at: http://www.activewallst.com/register/ ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... Medistem Panama Inc. at the City of Knowledge in Panama, a 6 ... cells in the US earlier this year following FDA approval of a second ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... of fracture-specific plating options designed to address fractures of the distal tibia and ... , The Acumed Ankle Plating System 3 is composed of seven plate families ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Lady had ... she tore her cruciate ligament in her left knee. Lady’s owner Hannah sought the ... central Florida board-certified veterinary surgeon, to repair her cruciate ligament and help with the ...
Breaking Biology Technology: