Navigation Links
Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
Date:6/16/2008

The Stowers Institute's Rong Li Lab has discovered that a protein previously shown to have a role in inflammation may also have a role in the formation of cysts in Autosomal Dominant Polycystic Kidney Disease (ADPKD) one of the most common life-threatening genetic diseases and has shown that a drug inhibiting the protein can slow the disease in mice.

The discovery was published in the advance online publication of Nature Medicine yesterday.

The team showed that a pro-inflammatory cytokine protein tumor necrosis factor-alpha (TNF-alpha) disrupts the localization of polycystin 2 the product of a gene mutated in ADPKD) to the plasma membrane and primary cilia in kidney epithelial cells, thus promoting the formation of cysts.

"The interaction between TNF-alpha and polycystin in the development of cysts is complicated," said Xiaogang Li, Ph.D., Senior Research Associate in the Rong Li Lab and first author on the paper. "We believe that this interaction could play a significant role in the transition from normal tubule development to the onset of Polycystic Kidney Disease (PKD) in individuals predisposed for the disease."

Additionally, the team found that the drug etanercept, an inhibitor of TNF-alpha currently used to treat rheumatoid arthritis and a number of other conditions, prevents the formation of cysts in the kidneys of mice with ADPKD.

"This discovery is especially exciting because it not only provides insight about the origins of ADPKD, but it also points us toward a drug that we believe shows promise in preventing the development of cysts," said Rong Li, Ph.D., Investigator and senior author on the publication. "Of course, additional research will be required to test these preliminary results in animal models, but the potential is interesting."

Currently, no treatments are available to prevent or delay the onset of cysts in people living with PKD. Dialysis and kidney transplants are often required as the disease progresses.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Study identifies warning signs of pregnancy danger
2. Study identifies genetic risk factor for rheumatoid arthritis, lupus
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Smithsonian identifies invasive crab species in Panama Canal expansion area
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. New technology identifies warped fingerprints at warp speed
8. Study identifies pathway required for normal reproductive development
9. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
10. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
11. Baumann lab identifies elusive telomere RNA subunit in single cell model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... FL (PRWEB) , ... October ... ... (RPS®) today announces publication of a United States multicenter, prospective clinical study ... use, disposable, point-of-care diagnostic test capable of identifying clinically significant acute bacterial ...
(Date:10/11/2017)... CA (PRWEB) , ... October 11, 2017 , ... ... upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding the ... system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give ... Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles ...
Breaking Biology Technology: