Navigation Links
Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
Date:6/16/2008

The Stowers Institute's Rong Li Lab has discovered that a protein previously shown to have a role in inflammation may also have a role in the formation of cysts in Autosomal Dominant Polycystic Kidney Disease (ADPKD) one of the most common life-threatening genetic diseases and has shown that a drug inhibiting the protein can slow the disease in mice.

The discovery was published in the advance online publication of Nature Medicine yesterday.

The team showed that a pro-inflammatory cytokine protein tumor necrosis factor-alpha (TNF-alpha) disrupts the localization of polycystin 2 the product of a gene mutated in ADPKD) to the plasma membrane and primary cilia in kidney epithelial cells, thus promoting the formation of cysts.

"The interaction between TNF-alpha and polycystin in the development of cysts is complicated," said Xiaogang Li, Ph.D., Senior Research Associate in the Rong Li Lab and first author on the paper. "We believe that this interaction could play a significant role in the transition from normal tubule development to the onset of Polycystic Kidney Disease (PKD) in individuals predisposed for the disease."

Additionally, the team found that the drug etanercept, an inhibitor of TNF-alpha currently used to treat rheumatoid arthritis and a number of other conditions, prevents the formation of cysts in the kidneys of mice with ADPKD.

"This discovery is especially exciting because it not only provides insight about the origins of ADPKD, but it also points us toward a drug that we believe shows promise in preventing the development of cysts," said Rong Li, Ph.D., Investigator and senior author on the publication. "Of course, additional research will be required to test these preliminary results in animal models, but the potential is interesting."

Currently, no treatments are available to prevent or delay the onset of cysts in people living with PKD. Dialysis and kidney transplants are often required as the disease progresses.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Study identifies warning signs of pregnancy danger
2. Study identifies genetic risk factor for rheumatoid arthritis, lupus
3. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
4. Breakthrough research identifies how cells from pigs may cure diabetes
5. Smithsonian identifies invasive crab species in Panama Canal expansion area
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. New technology identifies warped fingerprints at warp speed
8. Study identifies pathway required for normal reproductive development
9. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
10. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
11. Baumann lab identifies elusive telomere RNA subunit in single cell model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)...  Hunova, the first robotic gym for the rehabilitation and functional motor ... Genoa, Italy . The first 30 robots will be ... USA . The technology was developed and patented at the ... spin-off Movendo Technology thanks to a 10 million euro investment from entrepreneur ... ...
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... ... ... Algenist continues to disrupt the skincare industry with today’s debut of GENIUS Liquid ... the key structural element skin needs to maintain its youthful appearance and Algenist is ... First to market with proprietary collagen water active , Active ...
(Date:8/10/2017)... ... August 09, 2017 , ... Teachers from three Philadelphia middle ... 14th through the 16th, the University City Science Center will kick off the ... provides Philadelphia-based middle school educators an opportunity for professional development related to STEM ...
(Date:8/10/2017)... ... August 09, 2017 , ... Okyanos Center for Regenerative Medicine has announced its ... Hotel in Freeport, Grand Bahama on September 27, 2017. This daytime event is free ... from the Ministry of Health’s National Stem Cell Ethics Committee (NSCEC) and regulations laid ...
(Date:8/10/2017)... USA, and CARDIFF, UK (PRWEB) , ... August ... ... and photonics, has announced an agreement establishing Kinokuniya Company Ltd. as its exclusive ... SPIE as the exclusive sales representative for the SPIE Digital Library in Japan. ...
Breaking Biology Technology: