However, the report points to increasing evidence that women whose gut bacteria have little or no capacity to covert daidzein to S-equol may continue to suffer from severe hot flashes despite daidzein supplementation. The report suggests that dietary supplements providing higher proportions of genistein or S-equol may provide more relief of menopausal symptoms than the modestly effective relief recognized by soy isoflavones alone. Also, the report recommends a supplement containing natural S-equol may be effective for some women who do not have the capacity to produce S-equol, which occurs only when certain bacteria are present in the digestive tract.
The authors' menopause symptom treatment recommendations were based on a review of 14 studies that included data on soy isoflavone content and dosing, at least 12 weeks of treatment, women who experienced natural (not induced) menopause and the women's average age, their prevalence of hot flashes at study start and their magnitude of symptom improvement.
Potential Protection for Breast and Endometrial Cancer
Soy foods, in populations that typically consume them, appear to protect against breast cancer. Therefore, the NAMS report advises that moderate life-long dietary soy consumption is recommended as part of a healthy lifestyle. The best evidence indicates that there are no adverse effects from this diet and it has potential for prevention of breast and endometrial cancer, the report states.
However, the authors note that specific recommendations regarding soy food or soy isoflavone consumption by breast cancer survivors cannot be made at this time, although such studies in humans indicate either no effect or a protective effect, but in contrast laboratory and rodent studies indicate a potential for risk.
The authors recommend studies of end
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