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Role of soy in menopausal health reported
Date:8/30/2011

ians and well-respected scientific research experts in women's health and botanicals who participated in the symposium in October 2010. They examined basic and clinical research findings from more than two hundred key published controlled trials as well as laboratory studies of the soy isoflavones genistein and daidzein and the daidzein metabolite, S-equol. A supplement containing Natural S-equol for the management of menopausal symptoms is in development by Pharmavite LLC, the makers of Nature Made vitamins and minerals and a subsidiary of Otsuka Pharmaceutical Co., Ltd.

About Soy Isoflavones and S-Equol

Soy isoflavones are compounds that can bind to estrogen receptors. The isoflavones genistein and daidzein are primarily found in whole soybeans and soy products. S-equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman] is a compound resulting -- when certain bacteria are present in the digestive tract -- from the metabolism, or conversion, of daidzein.

S-equol binds to the same estrogen receptors as naturally occurring, endogenous estrogen, but with a stronger affinity for the estrogen beta receptor. On binding to these receptors, S-equol mimics some, but not all, activities of endogenous estrogen. Because of these actions, it has been proposed that S-equol alleviates some of the symptoms caused by diminished estrogen production during menopause.

However, not everyone can produce S-equol after soy consumption, as the production depends on the types of bacteria present in the large intestine and may be influenced by the amount of soy consumed. About 50 percent of Asians and 20 to 30 percent of North Americans and Europeans, who in general consume less soy than Asians, have the ability to produce high levels of S-equol. Controlled clinical trials have documented that a supplement containing Natural S-equol reduces the frequency of hot flashes as well as muscle discomfort associated with menopause, in women both in Japan and the U
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Contact: Stephen McCauley
smccauley@porternovelli.com
202-973-3615
Porter Novelli
Source:Eurekalert

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