Navigation Links
Role for sugar uptake in breast cancer revealed
Date:12/18/2013

p>

Bissell began exploring the relationship between aerobic glycolysis and malignant cells more than 40 years ago. She was intrigued with a hypothesis proposed in 1924 by biochemist and future Nobel laureate Otto Heinrich Warburg, which held that increased aerobic glycolysis at the expense of respiration and higher ATP production is a cause and not a symptom of cancer. This hypothesis became controversial because many researchers could find aerobic glycolysis in normal cells. Even now the majority view holds that increased sugar uptake in cells is the result of the intense metabolic demands of tumor cells and not a cause of malignant transformation

"In a series of papers published in the early 1970s, using fibroblasts from chick embryos and their malignant counterparts, we showed that if the microenvironmental context was equalized, the rate of aerobic glycolysis was indeed higher in cancer cells under all conditions tested," Bissell says. "Clearly Warburg was correct in saying that cancer cells always had increased aerobic glycolysis; however, he was not necessarily correct in saying that the defect had to be in respiratory pathways. We found these pathways to be similarly active in normal and malignant fibroblasts, as we find also now in our breast cancer cell studies in 3D assays."

Bissell would go on to discover that the cause of increased aerobic glycolysis was a dramatic increase in glucose uptake by cancer cells, but at that time did not determine whether this increase was the cause of malignant transformation. In this new study with Onodera and Jin-Min Nam of Japan's Hokkaido University, 3D laminin-rich extracellular matrix cultures of non-malignant human breast epithelial cells from a reduction mammoplasty were compared to malignant cells derived from the study's non-malignant cells.

Bissell says this demonstration of an active role in breast cancer development for glucose uptake could only have been revealed through a 3D
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Zinc sulfate, sugar alcohol zinc sprays improve apple quality
2. Brain may play key role in blood sugar metabolism and development of diabetes
3. Mutual benefits: Stressed-out trees boost sugary rewards to ant defenders
4. Sugar intake is not directly related to liver disease
5. Measuring blood sugar with light
6. UCLA engineers develop new metabolic pathway to more efficiently convert sugars into biofuels
7. Specific sugar molecule causes growth of cancer cells
8. For disappointed sports fans, defeats increase consumption of fat and sugar
9. Peoples diets show a sugar-fat seesaw
10. Lift weights to lower blood sugar? White muscle helps keep blood glucose levels under control
11. Kids consumption of sugared beverages linked to higher caloric intake of food
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Role for sugar uptake in breast cancer revealed
(Date:10/17/2014)... news release is available in German . ... millions of sperms every day in order to reproduce? And ... are the topic of the latest issue of the research ... 2014). The evolutionary biologist Steven Ramm from Bielefeld University Bielefeld ... it is not unusual for a female to copulate with ...
(Date:10/16/2014)... a new synthesis of recent research findings to inform ... the two states. , The Ecology and Management ... A Synthesis of the Relevant Biophysical Science and Implications ... by the U.S. Forest Service,s Pacific Northwest Research Station, ... for a synthesis of the large body of scientific ...
(Date:10/16/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market announces that ... Smart Wallet, at the 13 th annual Future ... conference on the intersection of technology and the economy. ... founder and publisher of the Strategic News Service™, the ...
Breaking Biology News(10 mins):Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... the United States by spending less money on making ... to the patients who need them, according to a ... and public health physician. , "For every dollar Congress ... treatments, it spends only one penny to ensure that ...
... sophisticated visual system than previously thought, according to a ... were able to solve complicated colour puzzles. The findings ... most difficult challenges of vision - namely, recognizing different ... that bees solve this problem using their experience with ...
... hear. Their brains learn to understand the artificial electrical ... sound. , A Stanford neurobiologist teamed with child-development specialists ... with cochlear implants were able to meld their newly ... In other words, did their brains process speech the ...
Cached Biology News:Access to existing medical treatments could save more lives than spending to improve the treatments 2Access to existing medical treatments could save more lives than spending to improve the treatments 3Bees solve complex colour puzzles 2Sooner is better with cochlear implants, Stanford scientist shows 2Sooner is better with cochlear implants, Stanford scientist shows 3
(Date:10/22/2014)... and HONG KONG , ... rare disease therapeutics enterprise, announced today that rare disease ... company as vice president, research. Dr. McKew brings more ... key leadership positions at the National Institutes of Health, ... acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts to ...
(Date:10/20/2014)... 2014 Convey Computer , the ... from Iowa State University won first place in the ... Convey HC-2ex, the team’s solution achieved the highest overall ... the second place finisher. , Experts from all segments ... month long challenge, using a variety of design tools, ...
(Date:10/20/2014)... October 20, 2014 , A ... disorders and the delivery of care has revealed changing ... worrying inequalities in the provision of healthcare services across ... commissioned by United European Gastroenterology (UEG), have been announced ... public awareness of the burden of GI disorders across ...
(Date:10/20/2014)... N.J. (PRWEB) October 20, 2014 ... the Sidney Kimmel Cancer Center at Thomas Jefferson ... , Through the Strategic Alliance Partnership program, ... OncLive will collaborate to raise awareness of the ... treatment, and other projects. Clinicians and other health ...
Breaking Biology Technology:aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
... by Sapna Chacko , ... High quality, DEPC treated, and non-DEPC , treated water , ... , Available in sizes to suit all your , ... for RNA isolation and analysis can contribute to experimental , ...
... ... fastest, easiest, and most consistent method for PAGE purification of small ... which was designed for the visualization of small nucleic acids, ... the purification of RNA , and DNA. ...
... , , Orders of magnitude better ... , Perform DNA digestion and sample , ... Preserve RNA quality , ... the removal of contaminating genomic DNA from RNA samples in , ...
Cached Biology Technology:Which Water to Use? 2Which Water to Use? 3Which Water to Use? 4Which Water to Use? 5Which Water to Use? 6Ultra-Fast Purification of Small Nucleic Acids 2Ultra-Fast Purification of Small Nucleic Acids 3Ultra-Fast Purification of Small Nucleic Acids 4Ultra-Fast Purification of Small Nucleic Acids 5The Fastest, Simplest, and Most Effective Way to Remove DNA Contamination 2The Fastest, Simplest, and Most Effective Way to Remove DNA Contamination 3
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
Full-length cDNA clone CS0DJ013YG01 of T cells (Jurkat cell line) of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86SZ3] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
...
Biology Products: