Navigation Links
Rogue receptor opens door for rare kidney disease
Date:9/25/2011

Effects of a particularly devastating human kidney disease may be blunted by making a certain cellular protein receptor much less receptive, according to new research by scientists from North Carolina State University and a number of French universities and hospitals.

The findings take a major step toward suggesting a beneficial treatment for rapidly progressive glomerulonephritis (RPGN), a rare but debilitating kidney disease that causes renal failure and death in humans.

In a paper published online in Nature Medicine, the researchers show that blocking the ability of the epidermal growth factor (EGF) receptor an important component in wound healing to bind with certain molecules in the kidneys of mice can eliminate the harmful effects of a mimic version of RPGN.

EGF receptors act like important keyholes on a cell's surface, says Dr. David Threadgill, professor and head of NC State's Department of Genetics and a co-author of the paper. Certain keys, or in this case molecules, can fit with the receptor and "open the door" to a cascade of cellular processes leading to inflammation, which can be good when your body needs to heal a wound or a cut. It's bad, however, when the inflammation runs amok, as when RPGN takes hold.

How important are EGF receptors in RPGN? When EGF receptors were taken out of the equation through special mice from Threadgill's lab that were genetically engineered without EGF receptors the disease was unable to take hold and degenerate kidney tissues.

The study also showed that certain drugs that inhibit EGF receptors think of them as pieces of gum in the keyholes not only prevented mouse kidneys from degrading but also reversed the harmful effects four days after mice were exposed to the RPGN mimic.

"EGF receptors are essential components for life, but are implicated in not only RPGN but also a number of cancers like colon cancer and breast cancer," Threadgill says. "They must be tightly regulated. If we can inhibit these receptors for short periods of time, we may be able to stop out-of-control cell proliferation and inflammation and thus prevent or treat certain cancers or diseases."


'/>"/>

Contact: Mick Kulikowski
mick_kulikowski@ncsu.edu
919-515-8387
North Carolina State University
Source:Eurekalert

Related biology news :

1. Rogue blood cells may contribute to post-surgery organ damage
2. Blocking rogue gene could stop the spread of most cancers
3. How do we kill rogue cells?
4. iGEM team helps prevent rogue use of synthetic biology
5. Oregons Rogue River Basin to face climate-change hurdles
6. Small molecule receptor detects lipids telltale sign of cell death
7. USC scientists generate first detailed map of human neuroreceptor
8. Penn researchers help graft olfactory receptors onto nanotubes
9. Your brain on nicotine: Nicotine receptors affect social behavior
10. The connection between a cells cytoskeleton and its surface receptors
11. Adrenaline receptor frozen in action by VIB researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... Research and Markets has announced the addition of the "Global ... 2025" report to their offering. ... The Global Vehicle Anti-Theft System Market is ... next decade to reach approximately $14.21 billion by 2025. ... all the given segments on global as well as regional levels ...
(Date:3/22/2017)... 21, 2017 Optimove , provider ... retailers such as 1-800-Flowers and AdoreMe, today announced ... and Replenishment. Using Optimove,s machine learning algorithms, these ... and replenishment recommendations to their customers based not ... of customer intent drawn from a complex web ...
(Date:3/20/2017)... 2017 At this year,s CeBIT Chancellor Dr. ... DERMALOG. The Chancellor came to the DERMALOG stand together with the Japanese ... CeBIT partner country. At the largest German biometrics company the two government ... and iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
Breaking Biology News(10 mins):
(Date:7/14/2017)... (PRWEB) , ... July 13, 2017 , ... Dr. Joshua ... ailing dental implants into his practice, Mondlick Perio, in the Phoenix area. ... the world's first and only FDA cleared laser treatment to re-grow bone and with ...
(Date:7/13/2017)... IN (PRWEB) , ... July 13, 2017 , ... Thousands ... July and August for the National Aeromodeling Championships (Nats). Pilots come to Muncie to ... try to earn spots on US teams that participate in world championships. , RC ...
(Date:7/13/2017)... ... July 13, 2017 , ... ... spectrophotometer calibration standards. Blast forward seven years and now they are home ... holmium oxide for wavelength accuracy, and resolution testing. , One ...
(Date:7/13/2017)... ... 13, 2017 , ... Trinity Sterile, Inc., a fast-growing healthcare ... chosen The Copley Consulting Group to implement and deploy the Infor CloudSuite Industrial ... and backend operations to streamline efficiencies to meet the increasing demand for cost-saving ...
Breaking Biology Technology: