Navigation Links
Rogue blood cells may contribute to post-surgery organ damage
Date:6/26/2011

A study from scientists at Queen Mary, University of London, sheds new light on why people who experience serious trauma or go through major surgery, can suffer organ damage in parts of the body which are seemingly unconnected to the injury.

The study, published today in Nature Immunology*, examines the way certain white blood cells, called neutrophils move out of blood vessels to defend damaged organs against injury or infection.

This is normally a one-way journey but researchers were surprised to find that, in some cases, this process can go into reverse, with rogue super-activated neutrophils, re-entering the blood stream and causing damage to other parts of the body.

The researchers used a cutting edge imaging technique which allowed them to watch the movement of neutrophils, in three dimensions and in real time in mice. As they expected the neutrophils moved out of blood vessels and into tissues to tackle injury or infection and they showed that his process was being controlled by a protein on the surface of the blood vessels called JAM-C.

However, when they temporarily blocked the blood vessels, mimicking the trauma experienced by patients undergoing major surgery, JAM-C was lost from the blood vessels. When this happened the neutrophils seemed to loose their way. Cells that had already exited blood vessels returned to the blood stream and damaged other parts of the body. In particular, the researchers found that these confused but highly activated neutrophils lodged into blood vessels in the lungs where they appeared to cause inflammation and damage to lungs.

Further research on the JAM-C molecule and the properties of these rogue neutrophils could lead to the development of drugs aimed at reducing life threatening complications following major surgeries such as inflammation of the lungs.

Professor Sussan Nourshargh who led the study said: "This is a really exciting piece of research as we
'/>"/>

Contact: Kerry Noble
k.noble@qmul.ac.uk
44-020-788-27943
Queen Mary, University of London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Blocking rogue gene could stop the spread of most cancers
2. How do we kill rogue cells?
3. iGEM team helps prevent rogue use of synthetic biology
4. Oregons Rogue River Basin to face climate-change hurdles
5. Scientists breakthrough attracts new funding for high blood pressure research
6. Device could improve harvest of stem cells from umbilical cord blood
7. Hematologist discovers, names the Toms River blood mutation in N.J. family
8. Scripps Research team sheds new light on how blood clots form
9. Blood clotting and bowel cancer risk
10. Wayne State to study the role of vitamin D in African-Americans with high blood pressure
11. Team solves decades-old molecular mystery linked to blood clotting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... that marine noise can affect animal movement and communication, ... Bristol and Exeter and the cole Pratique des Hautes ... noise stops embryonic development and increases larval mortality in ... Stylocheilus striatus used in this study) usually ... feed on toxic alga but this study, conducted in ...
(Date:7/30/2014)... New York University is paving the way for ... civilians and military troops exposed to poisonous chemicalsparticularly ... An article in the current issue of the ... detoxifying organophosphates, which are compounds commonly used in ... developed by NYU School of Engineering Associate Professor ...
(Date:7/30/2014)... Lewis Carroll,s Through the Looking Glass, collaborators from ... Singapore improved a 35-year-old ecology model to better ... of years. , The new model, called a ... Queen Effect," an evolutionary hypothesis introduced by Lee ... organisms must constantly increase their fitness (or ability ...
Breaking Biology News(10 mins):Boat noise impacts development and survival of sea hares 2Engineering a protein to prevent brain damage from toxic agents 2Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3
... G&D, Dr. Guillermo Oliver (St. Jude Childrens ... resolve a century-old debate over the origin of ... the lymphatic vasculature is integral to understanding its ... tissue fluid levels) and disease (lymphedema and spreading ...
... of the scientific journal Science presents research on the ... that ultimately may lead to better diagnosis and treatment ... people every year. It may also bring an ... Giardia lamblia is an intestinal parasite that exists all ...
... Standards and Technology (NIST) today announced 56 ... development projects under the agencys Advanced Technology ... a broad range of technologies, including medical ... electronics, transportation, nanotechnology, energy conservation and automated ...
Cached Biology News:New Swedish research hope for millions of sufferers 2
(Date:7/31/2014)... July 31, 2014 Nearly 20,000 medical professionals ... Annual Meeting & Clinical Lab Expo in ... never-before-seen breakthroughs in diagnostic research and technology that will ... As of Wednesday, July 30, more than ... Meeting & Clinical Lab Expo, with more than 10,000 ...
(Date:7/31/2014)... Researchers at Johns Hopkins have mapped the sound-processing part ... both the proverbial forest and the trees in view. ... views of brain activity within mice, and it enabled ... mice "called" to each other. The results, which represent ... process language, appear online July 31 the journal ...
(Date:7/31/2014)... PORTOLA VALLEY, Calif. , July 31, 2014 /PRNewswire/ ... San Francisco Bay Area , has ... the University of Oxford,s commercialisation company. The potent anti-inflammatory ... David Greaves at the University of Oxford,s Sir ... The company, which has raised over $1.5 million ...
(Date:7/31/2014)... Research and Markets has announced ... report to their offering. ... of the genetic material or genomes of an organism. ... the discovery and development of diagnostic and therapeutic solutions ... Genomics is supported by three major product segments: Instruments, ...
Breaking Biology Technology:Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3New mapping approach lets scientists zoom in and out as the brain processes sound 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... the appointment of James Stoppert as President and Chief Executive Officer ... ... EON) September 3, 2008 -- Segetis is the first and ... wide range of industrial chemicals and plastics that are ultimately derived ...
... China, Sept. 3 ,Acesys Pharmatech and Provid Pharmaceuticals ... expertise and project management,capabilities of Provid in the ... structure of Acesys in China., The combined ... of medicinal chemistry for clients in the pharmaceutical ...
... tested new molecular tools for stem cell research to direct ... development programmes. , A collaborative team of scientists from ... (NESCI) have developed two synthetic molecules which can be used ... into other forms of tissue. , Their use ...
Cached Biology Technology: Stoppert Named as President and CEO at Breakthrough Renewable Technology Firm Segetis, Inc 2Acesys and Provid Announce Alliance for Medicinal Chemistry Services 2New stem cell tools to aid drug development 2New stem cell tools to aid drug development 3
... for ambient HPLC. Contains connections and ... two external devices such as RI ... analog output from the 90 detector ... Includes an input for synchronization with ...
... The FDSS6000 System is an imaging ... assay development and high throughput screening ... luminescence modalities., The Hamamatsu light sources ... our companys decades-long experience in photon ...
... and supplies, for 10 chips, provides ... perform standard-sensitivity RNA analysis (nanogram levels) ... automated electrophoresis system. Supplied are 1,250 ... StdSens stain, 20 microliters RNA ladder, ...
... 3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide White solid. PROTECT FROM ... cell-permeable sulfanamido-benzbromarone compound that acts as ... inhibitor of PTP1B (IC 50 ... for PTP1B 403 and PTP1B ...
Biology Products: