Navigation Links
Rogue blood cells may contribute to post-surgery organ damage
Date:6/26/2011

A study from scientists at Queen Mary, University of London, sheds new light on why people who experience serious trauma or go through major surgery, can suffer organ damage in parts of the body which are seemingly unconnected to the injury.

The study, published today in Nature Immunology*, examines the way certain white blood cells, called neutrophils move out of blood vessels to defend damaged organs against injury or infection.

This is normally a one-way journey but researchers were surprised to find that, in some cases, this process can go into reverse, with rogue super-activated neutrophils, re-entering the blood stream and causing damage to other parts of the body.

The researchers used a cutting edge imaging technique which allowed them to watch the movement of neutrophils, in three dimensions and in real time in mice. As they expected the neutrophils moved out of blood vessels and into tissues to tackle injury or infection and they showed that his process was being controlled by a protein on the surface of the blood vessels called JAM-C.

However, when they temporarily blocked the blood vessels, mimicking the trauma experienced by patients undergoing major surgery, JAM-C was lost from the blood vessels. When this happened the neutrophils seemed to loose their way. Cells that had already exited blood vessels returned to the blood stream and damaged other parts of the body. In particular, the researchers found that these confused but highly activated neutrophils lodged into blood vessels in the lungs where they appeared to cause inflammation and damage to lungs.

Further research on the JAM-C molecule and the properties of these rogue neutrophils could lead to the development of drugs aimed at reducing life threatening complications following major surgeries such as inflammation of the lungs.

Professor Sussan Nourshargh who led the study said: "This is a really exciting piece of research as we have been able to watch how white blood cells move out of blood vessels to enter parts of the body that need their help. But with the advanced imaging technique that we have developed we could also for the first time see neutrophils move back into blood vessels following trauma. The neutrophils that behave this way are very different from normal blood neutrophils in that they are highly activated and fully capable of causing damage to other organs."

"Neutrophils are usually our first line of defence against infection but they have the ability to cause many diseases. As we learn more about the complex processes that protect us against infections we also find ways of tackling inflammatory diseases where white blood cells are inappropriately switched on."


'/>"/>

Contact: Kerry Noble
k.noble@qmul.ac.uk
44-020-788-27943
Queen Mary, University of London
Source:Eurekalert

Related biology news :

1. Blocking rogue gene could stop the spread of most cancers
2. How do we kill rogue cells?
3. iGEM team helps prevent rogue use of synthetic biology
4. Oregons Rogue River Basin to face climate-change hurdles
5. Scientists breakthrough attracts new funding for high blood pressure research
6. Device could improve harvest of stem cells from umbilical cord blood
7. Hematologist discovers, names the Toms River blood mutation in N.J. family
8. Scripps Research team sheds new light on how blood clots form
9. Blood clotting and bowel cancer risk
10. Wayne State to study the role of vitamin D in African-Americans with high blood pressure
11. Team solves decades-old molecular mystery linked to blood clotting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/26/2016)... Research and Markets has announced ... 2016-2020"  report to their offering.  , ,     (Logo: ... analysts forecast the global multimodal biometrics market to ... period 2016-2020.  Multimodal biometrics is being ... the healthcare, BFSI, transportation, automotive, and government for ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... NEW YORK , May 26, 2016 ... industry, investors see value in this space. Today,s pre-market research ... Healthcare equities: Radius Health Inc. (NASDAQ: RDUS ), ... (NASDAQ: ARWR ), and Five Prime Therapeutics Inc. ... these stock technical briefings at: http://www.activewallst.com/ ...
(Date:5/26/2016)... ... May 26, 2016 , ... Kinder Scientific (KinderScientific.com), a ... that position the Company for the future. Kinder Scientific announces restructured ownership ... has been appointed Chairman of the Board, Curtis D. Kinghorn has been appointed ...
(Date:5/25/2016)... ... May 25, 2016 , ... Lajollacooks4u has become a rising hotspot for ... one of its top attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm ... and intimate team-building experience. , Each event kicks off with an olive oil and ...
(Date:5/25/2016)... ... May 25, 2016 , ... The Ankle ... plating options designed to address fractures of the distal tibia and fibula. This ... Acumed Ankle Plating System 3 is composed of seven plate families that span ...
Breaking Biology Technology: