Navigation Links
Rogue blood cells may contribute to post-surgery organ damage
Date:6/26/2011

A study from scientists at Queen Mary, University of London, sheds new light on why people who experience serious trauma or go through major surgery, can suffer organ damage in parts of the body which are seemingly unconnected to the injury.

The study, published today in Nature Immunology*, examines the way certain white blood cells, called neutrophils move out of blood vessels to defend damaged organs against injury or infection.

This is normally a one-way journey but researchers were surprised to find that, in some cases, this process can go into reverse, with rogue super-activated neutrophils, re-entering the blood stream and causing damage to other parts of the body.

The researchers used a cutting edge imaging technique which allowed them to watch the movement of neutrophils, in three dimensions and in real time in mice. As they expected the neutrophils moved out of blood vessels and into tissues to tackle injury or infection and they showed that his process was being controlled by a protein on the surface of the blood vessels called JAM-C.

However, when they temporarily blocked the blood vessels, mimicking the trauma experienced by patients undergoing major surgery, JAM-C was lost from the blood vessels. When this happened the neutrophils seemed to loose their way. Cells that had already exited blood vessels returned to the blood stream and damaged other parts of the body. In particular, the researchers found that these confused but highly activated neutrophils lodged into blood vessels in the lungs where they appeared to cause inflammation and damage to lungs.

Further research on the JAM-C molecule and the properties of these rogue neutrophils could lead to the development of drugs aimed at reducing life threatening complications following major surgeries such as inflammation of the lungs.

Professor Sussan Nourshargh who led the study said: "This is a really exciting piece of research as we have been able to watch how white blood cells move out of blood vessels to enter parts of the body that need their help. But with the advanced imaging technique that we have developed we could also for the first time see neutrophils move back into blood vessels following trauma. The neutrophils that behave this way are very different from normal blood neutrophils in that they are highly activated and fully capable of causing damage to other organs."

"Neutrophils are usually our first line of defence against infection but they have the ability to cause many diseases. As we learn more about the complex processes that protect us against infections we also find ways of tackling inflammatory diseases where white blood cells are inappropriately switched on."


'/>"/>

Contact: Kerry Noble
k.noble@qmul.ac.uk
44-020-788-27943
Queen Mary, University of London
Source:Eurekalert

Related biology news :

1. Blocking rogue gene could stop the spread of most cancers
2. How do we kill rogue cells?
3. iGEM team helps prevent rogue use of synthetic biology
4. Oregons Rogue River Basin to face climate-change hurdles
5. Scientists breakthrough attracts new funding for high blood pressure research
6. Device could improve harvest of stem cells from umbilical cord blood
7. Hematologist discovers, names the Toms River blood mutation in N.J. family
8. Scripps Research team sheds new light on how blood clots form
9. Blood clotting and bowel cancer risk
10. Wayne State to study the role of vitamin D in African-Americans with high blood pressure
11. Team solves decades-old molecular mystery linked to blood clotting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... , June 16, 2016 ... is expected to reach USD 1.83 billion by ... View Research, Inc. Technological proliferation and increasing demand ... are expected to drive the market growth. ... The development of advanced multimodal techniques ...
(Date:6/9/2016)... leader in attendance control systems is proud to announce the introduction of fingerprint attendance ... the right employees are actually signing in, and to even control the opening of ... ... ... Photo - ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... of its previously-announced cash tender offers (the "Offers") ... accrued and unpaid interest to, but not including, ... expenses related to the Offers) (the "Maximum Tender ... table below (collectively, the "Notes"). The terms and ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... focused on discovery and development of precision treatments for neurodegenerative diseases, today ... Alzheimer’s disease (AD) inhibited the direct neurotoxic effect of prion-like forms of ...
(Date:12/5/2016)... ... December 05, 2016 , ... This composition patent, ... cellulose nanofibrils. The composition claims are not limited to any particular process ... combination with polymers, carbon fibers, graphene, and other materials. A continuation application, ...
(Date:12/5/2016)... ... December 05, 2016 , ... In ... cervical and lumbar disc production, company President, Jake Lubinski will be traveling to ... the AxioMed disc in Cologne and Karlsruhe to discuss the benefits of a ...
Breaking Biology Technology: