Navigation Links
Rogue blood cells may contribute to post-surgery organ damage
Date:6/26/2011

A study from scientists at Queen Mary, University of London, sheds new light on why people who experience serious trauma or go through major surgery, can suffer organ damage in parts of the body which are seemingly unconnected to the injury.

The study, published today in Nature Immunology*, examines the way certain white blood cells, called neutrophils move out of blood vessels to defend damaged organs against injury or infection.

This is normally a one-way journey but researchers were surprised to find that, in some cases, this process can go into reverse, with rogue super-activated neutrophils, re-entering the blood stream and causing damage to other parts of the body.

The researchers used a cutting edge imaging technique which allowed them to watch the movement of neutrophils, in three dimensions and in real time in mice. As they expected the neutrophils moved out of blood vessels and into tissues to tackle injury or infection and they showed that his process was being controlled by a protein on the surface of the blood vessels called JAM-C.

However, when they temporarily blocked the blood vessels, mimicking the trauma experienced by patients undergoing major surgery, JAM-C was lost from the blood vessels. When this happened the neutrophils seemed to loose their way. Cells that had already exited blood vessels returned to the blood stream and damaged other parts of the body. In particular, the researchers found that these confused but highly activated neutrophils lodged into blood vessels in the lungs where they appeared to cause inflammation and damage to lungs.

Further research on the JAM-C molecule and the properties of these rogue neutrophils could lead to the development of drugs aimed at reducing life threatening complications following major surgeries such as inflammation of the lungs.

Professor Sussan Nourshargh who led the study said: "This is a really exciting piece of research as we have been able to watch how white blood cells move out of blood vessels to enter parts of the body that need their help. But with the advanced imaging technique that we have developed we could also for the first time see neutrophils move back into blood vessels following trauma. The neutrophils that behave this way are very different from normal blood neutrophils in that they are highly activated and fully capable of causing damage to other organs."

"Neutrophils are usually our first line of defence against infection but they have the ability to cause many diseases. As we learn more about the complex processes that protect us against infections we also find ways of tackling inflammatory diseases where white blood cells are inappropriately switched on."


'/>"/>

Contact: Kerry Noble
k.noble@qmul.ac.uk
44-020-788-27943
Queen Mary, University of London
Source:Eurekalert

Related biology news :

1. Blocking rogue gene could stop the spread of most cancers
2. How do we kill rogue cells?
3. iGEM team helps prevent rogue use of synthetic biology
4. Oregons Rogue River Basin to face climate-change hurdles
5. Scientists breakthrough attracts new funding for high blood pressure research
6. Device could improve harvest of stem cells from umbilical cord blood
7. Hematologist discovers, names the Toms River blood mutation in N.J. family
8. Scripps Research team sheds new light on how blood clots form
9. Blood clotting and bowel cancer risk
10. Wayne State to study the role of vitamin D in African-Americans with high blood pressure
11. Team solves decades-old molecular mystery linked to blood clotting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/19/2017)... , April 19, 2017 The ... vendor landscape is marked by the presence of several ... however held by five major players - 3M Cogent, ... companies accounted for nearly 61% of the global military ... companies in the global military biometrics market boast global ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... August 16, 2017 , ... Today, 3Bar Biologics Inc ... $2M in funding from an impressive group of investors, including Rev1 Ventures, Maumee ... With this investment, 3Bar is broadening availability of its groundbreaking offering that uses ...
(Date:8/16/2017)...  This year,s edition of the Inc. 5000 features a now-familiar name: ... has made the list for the third year in a row. Now ... companies based on a set of quantitative metrics. In addition, BioPoint was ... in the Bay State . ... Inc. 5000 ...
(Date:8/15/2017)... 2017 After spending the past two years building a ... collection, GeneFo now offers this platform to healthcare stakeholders (hospitals, foundations, ... adherence, and data collection vis a vis their members, under their ... launch of this offer. ... ...
(Date:8/15/2017)... Diego, CA (PRWEB) , ... August 15, 2017 ... ... company pioneering graphene biosensors that accelerate pharmaceutical and biotherapeutics development, announces the launch ... the number of steps needed to gain kinetic binding data for a wide ...
Breaking Biology Technology: