Navigation Links
Rockefeller Scientists discover new compound that rids cells of Alzheimer protein debris
Date:3/7/2011

If you can't stop the beta-amyloid protein plaques from forming in Alzheimer's disease patients, then maybe you can help the body rid itself of them instead. At least that's what scientists from New York were hoping for when they found a drug candidate to do just that. Their work appears in a research report online in The FASEB Journal (http://www.fasebj.org), and shows that a new compound, called "SMER28" stimulated autophagy in rat and mice cells. Autophagy is a process cells use to "clean out" the debris from their interior, including unwanted materials such as the protein aggregates that are hallmarks of Alzheimer's disease. In mice and rat cells, SMER28 effectively slowed down the accumulation of beta-amyloid.

"Our work demonstrates that small molecules can be developed as therapies, by activating a cellular function called autophagy, to prevent Alzheimer's disease," said Paul Greengard, Ph.D.,Nobel laureate and director of the Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University in New York, NY. "By increasing our understanding of autophagy, it might be possible to stimulate it pharmacologically or naturally to improve the quality of life for aging people."

Using mouse and rat cells, scientists tested various compounds for their ability to reduce the buildup of beta-amyloid by exposing cultured cells to compounds known to activate autophagy. The effects of these compounds were then compared by removing growth factors from the culture medium. Researchers then focused on the most effective compound, which was SMER28, to characterize the cellular components involved in this phenomenon. For that purpose, the effect of SMER28 on beta-amyloid formation was compared using normal cells or cells where the expression of genes known to be involved in autophagy was reduced or abolished. Results showed involvement of three important autophagic players, and one was essential for the effect of SMER28. This research represents a radically different approach to treating Alzheimer's disease, namely boosting a cellular mechanism to enhance the clearance of beta-amyloid, as well as other protein aggregates; and it opens a new therapeutic avenue for the treatment of this and other degenerative diseases.

"Autophagy has been called the cell's equivalent of urban renewal. In that sense, SMER28 functions as a cellular forklift to clear out unwanted debris," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "The Rockefeller group shows that strategies to remove the blight in cells that causes Alzheimer's disease are not only worth pursuing, but so far, appear to be very promising."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Rockefeller scientist to discuss stress of poverty at AAAS
2. Rockefeller Foundation supports expansion, training of e-health work force in developing world
3. Scripps Research scientists develop new test for pluripotent stem cells
4. Scripps Research scientists create cell assembly line
5. Scientists identify susceptibility factor for bipolar disorder
6. Scientists study control of invasive tree in western US
7. Flood-tolerant rice plants can also survive drought, say UC Riverside scientists
8. For first time, scientists show an HIV vaccine impacts the genetic makeup of the virus
9. Scientists discover genetic switch that increases muscle blood supply
10. Signaling path in brain may prevent that Im full message, UT Southwestern scientists discover
11. Scientists unravel the mysterious mechanics of spider silk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... NXTD ) ("NXT-ID" or the "Company"), a company ... of a new series of commercials on Time Warner Cable ... .  The commercials will air on Bloomberg TV, Fox Business ... show. --> NXTD ) ("NXT-ID" or the "Company"), ... the airing of a new series of commercials on Time ...
(Date:3/10/2016)... India , March 10, 2016 ... a new market research report "Identity and Access Management ... & Audit, Compliance, and Governance), by Organization Size, by ... to 2020", published by MarketsandMarkets, The market is estimated ... USD 12.78 Billion by 2020, at a Compound Annual ...
(Date:3/9/2016)... March 9, 2016  Crossmatch ® , a ... solutions, today announced the addition of smart features ... multi-factor authentication platform. New contextual and application-specific ... step-up security where it,s needed most — while ... DC . --> Washington, ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... The American Medical Informatics ... of the National Coordinator for Health IT (ONC) outlining a measurement approach to ... were available when and where it was needed. The organization of health informatics ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... and traumatic injuries, will be accelerated by research at Worcester Polytechnic Institute (WPI) ... of wound healing and tissue regeneration. , The novel method, developed by WPI ...
(Date:5/23/2016)... ... May 23, 2016 , ... PrecisionAg® Media has released ... and Beyond. The paper outlines the key trends that are creating both opportunities ... witnessed a lot of highs and lows as the precision agriculture market has ...
(Date:5/23/2016)... ... May 23, 2016 , ... ... on molecular nanotechnology, announced the winners for the 2015 Foresight Institute Feynman Prizes. ... are given in two categories, one for experiment and the other for theory ...
Breaking Biology Technology: