Navigation Links
Rockefeller Scientists discover new compound that rids cells of Alzheimer protein debris
Date:3/7/2011

If you can't stop the beta-amyloid protein plaques from forming in Alzheimer's disease patients, then maybe you can help the body rid itself of them instead. At least that's what scientists from New York were hoping for when they found a drug candidate to do just that. Their work appears in a research report online in The FASEB Journal (http://www.fasebj.org), and shows that a new compound, called "SMER28" stimulated autophagy in rat and mice cells. Autophagy is a process cells use to "clean out" the debris from their interior, including unwanted materials such as the protein aggregates that are hallmarks of Alzheimer's disease. In mice and rat cells, SMER28 effectively slowed down the accumulation of beta-amyloid.

"Our work demonstrates that small molecules can be developed as therapies, by activating a cellular function called autophagy, to prevent Alzheimer's disease," said Paul Greengard, Ph.D.,Nobel laureate and director of the Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University in New York, NY. "By increasing our understanding of autophagy, it might be possible to stimulate it pharmacologically or naturally to improve the quality of life for aging people."

Using mouse and rat cells, scientists tested various compounds for their ability to reduce the buildup of beta-amyloid by exposing cultured cells to compounds known to activate autophagy. The effects of these compounds were then compared by removing growth factors from the culture medium. Researchers then focused on the most effective compound, which was SMER28, to characterize the cellular components involved in this phenomenon. For that purpose, the effect of SMER28 on beta-amyloid formation was compared using normal cells or cells where the expression of genes known to be involved in autophagy was reduced or abolished. Results showed involvement of three important autophagic players, and one was essential for the effect of SMER28. This research represents a radically different approach to treating Alzheimer's disease, namely boosting a cellular mechanism to enhance the clearance of beta-amyloid, as well as other protein aggregates; and it opens a new therapeutic avenue for the treatment of this and other degenerative diseases.

"Autophagy has been called the cell's equivalent of urban renewal. In that sense, SMER28 functions as a cellular forklift to clear out unwanted debris," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "The Rockefeller group shows that strategies to remove the blight in cells that causes Alzheimer's disease are not only worth pursuing, but so far, appear to be very promising."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Rockefeller scientist to discuss stress of poverty at AAAS
2. Rockefeller Foundation supports expansion, training of e-health work force in developing world
3. Scripps Research scientists develop new test for pluripotent stem cells
4. Scripps Research scientists create cell assembly line
5. Scientists identify susceptibility factor for bipolar disorder
6. Scientists study control of invasive tree in western US
7. Flood-tolerant rice plants can also survive drought, say UC Riverside scientists
8. For first time, scientists show an HIV vaccine impacts the genetic makeup of the virus
9. Scientists discover genetic switch that increases muscle blood supply
10. Signaling path in brain may prevent that Im full message, UT Southwestern scientists discover
11. Scientists unravel the mysterious mechanics of spider silk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... --  EyeLock LLC , a market leader of iris-based ... IoT Center of Excellence in Austin, Texas ... embedded iris biometric applications. EyeLock,s iris authentication ... with unmatched biometric accuracy, making it the most proven ... platform uses video technology to deliver a fast and ...
(Date:4/28/2016)... First quarter 2016:   , ... the first quarter of 2015 The gross margin was ... 18.8) and the operating margin was 40% (-13) Earnings ... flow from operations was SEK 249.9 M (21.2) , ... SEK 7,000-8,500 M. The operating margin for 2016 is ...
(Date:4/15/2016)... , April 15, 2016 ... "Global Gait Biometrics Market 2016-2020,"  report to their ... ) , ,The global gait biometrics market ... 13.98% during the period 2016-2020. Gait ... which can be used to compute factors that ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Sequenom, Inc. (NASDAQ: ... enabling healthier lives through the development of innovative products ... the United States denied its ... the claims of Sequenom,s U.S. Patent No. 6,258,540 (",540 ... criteria established by the Supreme Court,s Mayo Collaborative Services ...
(Date:6/27/2016)... -- Liquid Biotech USA , Inc. ... Research Agreement with The University of Pennsylvania ("PENN") ... patients.  The funding will be used to assess ... outcomes in cancer patients undergoing a variety of ... to support the design of a therapeutic, decision-making ...
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
Breaking Biology Technology: