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Risk of surgery for Crohn's disease lower than reported in recent studies
Date:8/31/2010

r diagnosis as high as 34 percent and as high as 47 percent at five years following diagnosis. In this study, we examined the current incidence of bowel surgery." With an increase in the use of immunomodulators as a common therapy at the time of diagnosis in recent years, the researchers also examined its impact.

In terms of the risk of surgery, LeLeiko says, "We have identified older age at diagnosis and greater disease severity to be associated with an increased risk for bowel surgery, along with certain types of disease. The findings, however, indicate that other studies suggest an almost two times greater incidence of surgery than what we found in our study."

The researchers also found that children diagnosed between the ages of 13 and 16 were at greater risk for surgery, however they found no evidence that the early use of immunomodulators is a factor in 5-year surgical outcomes. They also found no link between gender, race or family history of inflammatory bowel disease as factors that would increase the risk of surgery.

LeLeiko concludes, "Our study findings indicate that changing disease behavior over time influences the risk of surgery, and treatments focused on early intervention to alter the natural course of the disease will need to be assessed in studies that ideally involve randomized controlled trials."


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Contact: Nancy Cawley Jean
njean@lifespan.org
Lifespan
Source:Eurekalert  

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