Navigation Links
Riding the exosome shuttle from neuron to muscle
Date:3/27/2013

ce. Once outside the cell, exosomes can then travel to other cells, where they are taken up. The recipient cells can then use the materials contained within exosomes, influencing cellular function and allowing the recipient cell to carry out certain processes that it might not be able to complete otherwise.

Budnik and colleagues made this startling discovery while investigating how the synapses at the end of neurons and nearby muscle cells communicate in the developing Drosophila fruit fly to form the neuromuscular junction (NMJ). The NMJ is essential for transmitting electrical signals between neurons and muscles, allowing the organism to move and control important physiological processes. Alterations of the NMJ can lead to devastating diseases, such as muscular dystrophy and Amyotrophic lateral sclerosis (ALS). Understanding how the NMJ develops and is maintained is important for human health.

As organisms develop, the synapse and muscle cell need to grow in concert. If one or the other grows too quickly or not quickly enough, it could have dire consequences for the ability of the organism to move and survive. To coordinate development, signals are sent from the neuron to the muscle cell (anterograde signals) and from the muscle cell to the neuron (retrograde signals). However, the identity of these signals and how their release is coordinated is poorly understood.

Normally, the vesicle protein Synaptotagmin 4 (Syt4) is found in both the synapse and the muscle cells. Previous knockout experiments eliminating the Syt4 protein from Drosophila have resulted in stunted NMJs. Suspecting that Syt4 played an important role in retrograde signaling at the developing NMJ, Budnik and colleagues used knockdown experiments to decrease Syt4 protein levels in either the neurons or the muscle cells. Surprisingly, when RNAi was used to knockdown Syt4 in the neurons alone, Syt4 protein was eliminated in both neurons and muscles. The opposi
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Tracking shuttle exhaust reveals more information about atmospheric winds
2. Age-related dementia may begin with neurons inability to dispose of unwanted proteins
3. Parkinsons disease: Parkin protects from neuronal cell death
4. Neuronal activity induces tau release from healthy neurons
5. Researchers turn one form of neuron into another in the brain
6. Stress-resilience/susceptibility traced to neurons in reward circuit
7. Neurons made from stem cells drive brain activity after transplantation in laboratory model
8. Cilia guide neuronal migration in developing brain
9. Persistent sync for neurons
10. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
11. Astrocytes control the generation of new neurons from neural stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... Calif. , Aug. 3, 2015 Synaptics, ... human interface solutions, today announced that members of the ... at the Pacific Crest Global Technology Leadership Forum on ... The conference will be held at the Sonnenalp Resort ... The presentation may include forward-looking information. An audio ...
(Date:7/31/2015)... 2015 La 10e Conférence internationale sur ... par le BGI du 22 au 25 octobre ... Chine. La conférence célèbre son 10e ... l,ICG est devenue l,une des réunions annuelles mondiales ... et c,est aussi la plus dynamique, la plus ...
(Date:7/31/2015)... SHENZHEN, China , July 31, 2015 The ... ) will be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th ... become one of the world,s most influential annual meetings in ... enthusiastic, and enjoyable scientific gatherings. ICG-10 focuses ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... Bioenergy crops, such as Miscanthus and switchgrass, appear to ... did not come with a manual on how to measure ... Illinois professor of energy and environmental law and chair of ... needed so farmers, ethanol producers, and others in the biofuels ...
... Kansas State University chemical engineer may help improve humidity ... Vikas Berry, William H. Honstead professor of chemical ... dots to improve sensing devices in a twofold project. ... which are ultrasmall pieces of graphene. Graphene is a ...
... Jayann Sepich , mother of murder victim ... ( www.DNASaves.org ) expressed appreciation for Sen. Hatch,s ( Utah ... special residency status, and for his continued commitment to victim issues. ... the United States illegally," said Mrs. Sepich.  "But ...
Cached Biology News:Setting the standard for sustainable bioenergy crops 2Setting the standard for sustainable bioenergy crops 3Setting the standard for sustainable bioenergy crops 4Researchers use graphene quantum dots to detect humidity and pressure 2Researchers use graphene quantum dots to detect humidity and pressure 3DNA Saves Applauds Proposed Hatch Amendment to the Immigration Reform Bill 2
(Date:8/28/2015)... ... August 28, 2015 , ... Pittcon is pleased ... present a session on chemical spectroscopic imaging at JASIS 2015 (Japan Analytical & ... largest analytical and scientific instruments show which will be held at International Conference ...
(Date:8/28/2015)... ... 28, 2015 , ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the ... service. Images such as the Fonz in a lab coat and Large Marge have ... humdrum spectroscopy field. , FireflySci is proud to be the only cuvette manufacturer ...
(Date:8/27/2015)... -- Neogen Corporation (NASDAQ: NEOG ) announced today that ... Kingdom -based Lab M Holdings, a developer, manufacturer ... Lab M was founded in 1971, ... testing and diagnostic products for the global food, water, ... into more than 70 countries worldwide, and has several ...
(Date:8/27/2015)... PARK, Calif. , Aug. 27, 2015  Asterias ... in the emerging field of regenerative medicine, today announced ... investor conferences in the month of September.  ... will present at Rodman & Renshaw,s 17th Annual Global ... ET/7:25am PT at the St. Regis Hotel in ...
Breaking Biology Technology:U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 2U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 3Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Neogen acquires U.K.-based Lab M Holdings 2Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2
... looking for an ambitious mission statement, consider this pledge from ... simply propose adding new dollars on top of current dollars, ... first those currently in the (K-12 public school) system, and ... the adequacy analysis." , , [Tom Still is a member ...
... a type of atom probe developed by Madison-based Imago ... of individual gold atoms they couldn't have gotten otherwise. ... was used to map the position of atoms in ... of Wisconsin-Madison technology and has sold it since 2003. ...
... Eau Claire, Wis. A digital welding simulator that ... several educational programs was demonstrated on Wednesday at Chippewa ... which was co-developed by the visual technology firm VRSim ... gain hours of welding experience without using up expensive metal ...
Cached Biology Technology:Measuring what works and what doesn't in the prototypical school 2Measuring what works and what doesn't in the prototypical school 3Virtual-reality welding simulator an opportunity for Chippewa Valley college 2
... or 384-well PCR plates Dimples on both sides ... plates End tabs on Thermo-Mat™ 384 fit into ... sealing is achieved with either Thermo-Mat™ 96 or 384 ... lid thermal cyclers Fully autoclavable May ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,667-7) ... assistance. ID clarifier: barcoded, bulk ...
Packaging: package with 500 l Patent/trademark/license (electronic): (r) Registered trademark of Molecular Probes...
... easy method for the isolation of ... tissues. Most of the isolated mitochondria ... The kit contains extraction buffers for ... Also included is a storage buffer ...
Biology Products: