Navigation Links
Riding the exosome shuttle from neuron to muscle
Date:3/27/2013

WORCESTER, MA Important new research from UMass Medical School demonstrates how exosomes shuttle proteins from neurons to muscle cells where they take part in critical signaling mechanisms, an exciting discovery that means these tiny vehicles could one day be loaded with therapeutic agents, such as RNA interference (RNAi), and directly target disease-carrying cells. The study, published this month in the journal Neuron, is the first evidence that exosomes can transfer membrane proteins that play an important role in cell-to-cell signaling in the nervous system.

"There has been a long-held belief that certain cellular materials, such as integral membrane proteins, are unable to pass from one cell to another, essentially trapping them in the cell where they are made," said Vivian Budnik, PhD, professor of neurobiology and lead author of the study. "What we've shown in this study is that these cellular materials can actually move between different cell types by riding in the membrane of exosomes.

"What is so exciting about this discovery is that these exosomes can deliver materials from one cell, over a distance, to a very specific and different cell," said Dr. Budnik. "Once inside the recipient cell, the materials contained in the exosome can influence or perform processes in the new cell. This raises the enticing possibility that exosomes can be packed with gene therapies, such as RNAi, and delivered to diseased cells where they could have a therapeutic effect for people."

Discovered in the mid-80s, exosomes have only recently attracted the attention of scientists at large, according to Budnik. Exosomes are small vesicles containing cellular materials such as microRNA, messenger RNAs (mRNAs) and proteins, packaged inside larger, membrane-bound bodies called multivesicular bodies (MVBs) inside cells. When MVBs containing exosomes fuse with the cell plasma membrane, they release these exosome vesicles into the extracellular spa
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Tracking shuttle exhaust reveals more information about atmospheric winds
2. Age-related dementia may begin with neurons inability to dispose of unwanted proteins
3. Parkinsons disease: Parkin protects from neuronal cell death
4. Neuronal activity induces tau release from healthy neurons
5. Researchers turn one form of neuron into another in the brain
6. Stress-resilience/susceptibility traced to neurons in reward circuit
7. Neurons made from stem cells drive brain activity after transplantation in laboratory model
8. Cilia guide neuronal migration in developing brain
9. Persistent sync for neurons
10. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
11. Astrocytes control the generation of new neurons from neural stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... -- Tute Genomics, a leader in cloud-based solutions for genome ... led by UK-based Eurovestech. Peak Ventures and a number ... "We are at a pivotal time in ... seeks new approaches for the diagnosis, treatment and prevention ... and CEO of Tute Genomics. "One of the main ...
(Date:12/3/2014)... 2014   Marvin Test Solutions , a ... for military, aerospace, and manufacturing organizations, today announced ... TS-900 PXI semiconductor test platform . The ... systems to customers at a fraction of the ... ATE. "Our semiconductor customers asked ...
(Date:11/21/2014)... According to a new market research report ... Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), End ... - Global Forecasts to 2020", published by MarketsandMarkets, The ... $25 Billion in 2014 and is expected to reach ... 8.69%. Browse 116 market data Tables and ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... 46 percent increase in lifespan, raising the tantalizing question ... also taking an anti-aging medication. Results of the Buck ... PhD, are currently published online in the Journal of ... treat mood affective disorders, including bipolar disease for decades. ...
... - In a feat that seems like something out of a ... to use a tractor beam of light to pick up, hold, ... of a microchip. The new technology could become an important ... Lang and David C. Appleyard, whose work is being published in ...
... for parents helps them better understand the diseases their ... while offering practical advice for preventing infections in their ... The Complete Guide to Protecting (without Overprotecting) Your Family ... the inside source on germ defense from antibiotics ...
Cached Biology News:Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms 2MIT develops 'tractor beam' for cells, more 2Handbook helps parents deal with childhood infections 2
(Date:12/24/2014)... On Friday, December 19, 2014, ... Omnibus and Continuing Resolution Appropriations Act of 2015, ... condition eligible to receive funding through the Congressionally ... Department of Defense (DoD). The Hydrocephalus Association (HA), ... Hill, is celebrating this victory for the over ...
(Date:12/24/2014)... 23, 2014 Pipette.com announces their ... followers can submit their #HolidayInTheLab pictures for a chance ... mates. , For those struggling to think of a ... Holiday in the Lab Contest provides the ideal holiday ... to send pictures of their chemistree, holiday sweaters, ...
(Date:12/24/2014)... , Dec. 23, 2014  Rock Creek Pharmaceuticals, Inc., ... has filed a Clinical Trial Application (CTA) with the ... Regulatory Agency (MHRA) seeking regulatory approval to initiate clinical ... Anatabine Citrate. Contingent on the Company receiving ... Phase I trial to assess the safety, tolerability and ...
(Date:12/22/2014)... , Dec. 22, 2014  Alternative Energy & ... it has signed a letter of intent to ... developed and patented a nanotechnology-based development platform used ... that enable rapid on-site collection and testing to ... health issues in an immediate, non-invasive and cost-effective ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3ALNE Announces Intention To Acquire BioTechPharma 2
... The Drug Information Association (DIA) will host two co-located ... ... Horsham, PA (PRWEB) ... (DIA)] will host two co-located conferences from October 23-24 ...
... your lap lately, you probably noticed a burning sensation. ... more heat, which has to go somewhere in ... the University of Virginia,s School of Engineering and Applied ... solve the problem using nanoelectronics, considered the essential science ...
... 29 If one Delaware man,s vision,comes true, ... tumors as,they are with breast cancer, and to ... in the Game(R), an awareness campaign in his ... Kelly Heinz-Grundner Brain Tumor Foundation,and early this month ...
Cached Biology Technology:DIA Co-located Conference to Examine Outsourcing and Project Management Best Practices 2Engineers aim to solve 'burning' computer problem 2Delaware Man Spearheads Brain Tumor Awareness 2