Navigation Links
Rictor protein offers scientists a new molecular target for cancer therapies
Date:10/28/2010

BOSTON The discovery that a protein called Rictor plays a key role in destroying a close cousin of the AKT oncogene could provide scientists with a new molecular target for treating certain cancers, including breast cancer. Described in the September 2010 issue of the journal Molecular Cell, the study was led by scientists at Beth Israel Deaconess Medical Center (BIDMC).

The oncogenic cousin, known as SGK1, resembles the widely known AKT oncogene in structure, according to the study's senior author Wenyi Wei, PhD, of the Department of Pathology at BIDMC and Assistant Professor of Pathology at Harvard Medical School (HMS).

"If we put the two proteins together, they are very similar," explains Wei. "But in one important way they are very different. AKT is stable, it lives for a long time. But SGK1 has a very short lifespan, and proteins with short lifespans tend to be powerful. Everybody's eye [has been] on AKT, but you have to wonder if this little cousin of AKT can do all the things AKT does." Wei and his team, therefore, set out to better understand how cells control SGK1.

Previous research showed that the protein Rictor forms a multi-protein complex called mTORC2 that activates both AKT and SGK1. Wei's team cultured cells lacking Rictor to observe the effect on SGK1. Surprisingly, they found that SGK1 levels increased.

"We said, that cannot be," notes Wei. "How could we get rid of the protein kinase that activates SGK1 and still have the SGK1 levels be heightened?"

They found their answer when they observed that the cells weren't producing more SGK1; rather, SGK1 was living longer. This suggested to the scientists that Rictor might be playing a role in the destruction of SGK1. And, in subsequent experiments, Wei found that SGK1 is indeed held in check by a protein complex made up of Rictor, Cullin-1, Rbx1, and possibly other components. The protein complex forms a cellular garbage collector called a
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Structural genomics accelerates protein structure determination
2. Too much SP2 protein turns stem cells into evil twin cancer cells
3. Elsevier introduces Protein Viewer, bringing science to life
4. LSUHSC study IDs proteins regulating water retention in salt-sensitive hypertension
5. Discovery of a mechanism that controls the expression of a protein involved in numerous cancers
6. Biodegradable foam plastic substitute made from milk protein and clay
7. Reaper protein strikes at mitochondria to kill cells
8. New clues to how cancer-related proteins plasmin, thrombin lose inhibition
9. UMMS researchers identify protein associated with sporadic ALS
10. Key difference in how TB bacteria degrade doomed proteins
11. Shifting forms: Penn study shows how variations of same protein affect immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... GOTHENBURG, Sweden , June 16, 2015 ... including all touch fingerprint sensors in the company,s portfolio from ... . Deliveries are planned to mainly take place during the ... manufacturers in Asia . Jörgen ... another evidence of    the   growing interest from smartphone ...
(Date:6/15/2015)... -- According to a new market research ... and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image ... The Natural Language Processing Market is expected to grow ... the forecast period 2015-2020. Browse 65 ... spread   through 155 P ages and in-depth ...
(Date:6/15/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") a ... announces that its leading payment security technology, the Wocket® smart ... NYC June 18th. Digital Experience! @ NYC is ... to over 300 of the top media covering the sector. ... New York City from 6:00 to ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 5Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
... to evolution; it allows genetic material from parents to ... how did sex itself evolve" Researchers at the Department ... of California at Berkeley have found clues to one ... the nematode Caenorhabditis elegans. , Abby Dernburg, of ...
... Chocolate Chip Cookies TM lower cholesterol and improve ... according to a published study in The Journal of ... a combination of psyllium and plant sterols, are a ... cholesterol. , The American Heart Association estimates at ...
... a screen and a bucket, scientists studying a tiny primitive ... Tampa Bay now say they have found the "missing link" ... of the modern-day human immune system. , The inch-long spineless ... that is similar to but much hardier than the version ...
Cached Biology News:New clues to how sex evolves 2New clues to how sex evolves 3New clues to how sex evolves 4New study finds chocolate chip cookies lower cholesterol 2Tiny Tampa Bay fish key to evolution of immune system 2Tiny Tampa Bay fish key to evolution of immune system 3
(Date:7/7/2015)... 7, 2015  In the farthest reaches of the ... Matsés tribe came together in a quest to save ... gathering, held in May in a remote village on ... , concluded over two years work and culminated ... ever written by an Amazonian tribe. The 500-page repository ...
(Date:7/7/2015)... ... , ... The global aptamers market is expected to reach ... of 17.89% between 2015 and 2020. The aptamer type segments included in this ... report is segmented into diagnostics, therapeutics development, R&D, and other applications. Diagnostics applications ...
(Date:7/6/2015)... CARDIFF, UK (PRWEB) , ... July 06, 2015 ... ... and other medical fields holds potential to reveal how blood flows in the ... stroke-induced damage to the brain. , A new article published in the journal ...
(Date:7/6/2015)... ... July 06, 2015 , ... Discovery of new biomarkers for ... drivers of the global molecular diagnostics market. BCC Research reveals in its new ... companion diagnostic tests will increase demand for inexpensive and accurate tests for genetic ...
Breaking Biology Technology:Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 2Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 3Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 4Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 2Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 3Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 4Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 5Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 3Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3
... Webcast Presentation Scheduled for Wednesday, January 14, 2009 at ... Colo. and SAN CARLOS, Calif., Jan. 8 ARCA ... heart failure and other cardiovascular diseases, and Nuvelo, Inc. ... Brewer, ARCA,s president and chief executive officer, will present ...
... Concentric Medical, Inc., the global leader in devices ... that it has completed a $15 million round of ... capital firm New Enterprise Associates, Inc. (NEA) and includes ... Concentric over the last several months made the opportunity ...
... Remote Patient Monitoring Projected to Exceed $8 Billion ... Inc., developer of LifeShirt(R), a continuous, integrated and ... that president and chief executive officer Howard Baker ... January 14, 2009 at the Marines Memorial Club ...
Cached Biology Technology:ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference 2ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference 3ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference 4ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference 5Concentric Medical Closes on $15 Million Financing 2VivoMetrics to Present at the 2009 Biotech Showcase 2VivoMetrics to Present at the 2009 Biotech Showcase 3
... a base medium for preparation of minimal and ... but does not contain amino acids. Both bulk ... pouch contains reagents to prepare 500 ml of ... of 10X YNB for S. cerevisiae media. Store ...
... Progesterone Receptor (PR) Competitor Assay Kits ... novel progesterone receptor binding compounds using ... utilizes a fusion of glutathione transferase ... human progesterone receptor [PR-LBD(GST)] and a ...
... Protein G bind specifically to Fc regions ... Protein G conjugates are commonly used as ... immunoglobulin subtypes from serum, hybridoma ascites fluids, ... These reagents are also commonly used to ...
... the first instrument engineered to match the ... by thousands of research centers worldwide. It ... which are ideally suited for high-speed temperature ... extremely high surface-area-to-volume ratio. ,By combining glass ...
Biology Products: