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Rich or poor in gut bacteria brings new vision for obesity treatment
Date:8/29/2013

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When comparing the two groups, they discovered that people with a low richness microbiota have more body fat and less healthy; they are more resistant to the action of insulin, have unfavorably altered blood lipids and show increased blood levels of inflammation markers and white blood cells, bringing them at increased risk of type 2 diabetes and cardiovascular disorders.

Interestingly, researchers also observed that obese people from the low richness group gained on average significantly more weight than the high richness one during the past nine years. Eight particular bacterial species were identified based on their possible protective role against weight gain. These findings could lead to the development of new medical therapies for fighting against weight gain.

Obesity is a major contributor to some of the leading causes of death, and lead to a global metabolic health crisis. The work here provides a solid evidence that studies of alterations in the "other" genome may define subsets of adult individuals with different metabolic risk profiles and thereby contribute to the development of stratified approaches for treatment and prevention of widespread obesity, heart disease, stroke, diabetes and some types of cancer associated with it.


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Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

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