Navigation Links
Rich or poor in gut bacteria brings new vision for obesity treatment

Shenzhen, China -- The MetaHIT consortium, comprised of Institute National de la Recherche Agronomique (INRA), University of Copenhagen, BGI, and other institutes, has investigated the gut microbial composition in a cohort of 123 non-obese and 169 obese Danish individuals. This study showed for the first time that 2 groups of individuals can be distinguished in the population by the richness of gut microbiota. The latest results were published online in Nature today.

Obesity, known as "the modem civilized disease", is a leading preventable cause of death worldwide that increases the likelihood of various diseases, particularly heart disease, type 2 diabetes, and others. It's reported that the obesity epidemic will affect more than 700 million in 2015 and will continue to grow. Each of our guts is colonized by more than 3 pounds of microorganisms. More and more data show that our "other" genome, the microbiome, may have greater consequences on the onset of obesity.

In this study, researchers analyzed the gut bacterial composition of 292 Danish adults by a new analytical approach called quantitative metagenomics. They found two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. A quarter of the cohort is "poor" in bacteria (low bacterial richness), whereas the rest is "rich" (high bacterial richness); Low richness individuals included a significantly higher proportion of obese participants and were as a group characterized by a more marked adiposity.

Their further efforts showed that the low richness microbiota contains higher proportion of pro-inflammatory and lower proportion of anti-inflammatory bacterial species than the high richness one. The two groups of individuals could be almost perfect stratified with very few bacteria, suggesting that simple molecular diagnostic tests, based upon the gut microbiome, can be developed to identify individuals at risk of common morbidities.

When comparing the two groups, they discovered that people with a low richness microbiota have more body fat and less healthy; they are more resistant to the action of insulin, have unfavorably altered blood lipids and show increased blood levels of inflammation markers and white blood cells, bringing them at increased risk of type 2 diabetes and cardiovascular disorders.

Interestingly, researchers also observed that obese people from the low richness group gained on average significantly more weight than the high richness one during the past nine years. Eight particular bacterial species were identified based on their possible protective role against weight gain. These findings could lead to the development of new medical therapies for fighting against weight gain.

Obesity is a major contributor to some of the leading causes of death, and lead to a global metabolic health crisis. The work here provides a solid evidence that studies of alterations in the "other" genome may define subsets of adult individuals with different metabolic risk profiles and thereby contribute to the development of stratified approaches for treatment and prevention of widespread obesity, heart disease, stroke, diabetes and some types of cancer associated with it.


Contact: Jia Liu
BGI Shenzhen

Related biology news :

1. Bacterial toxins cause deadly heart disease
2. UC Davis researchers discover molecular target for the bacterial infection brucellosis
3. High-angle helix helps bacteria swim
4. Newly discovered bacterial partnership changes ocean chemistry
5. Bacterial blockade
6. Study finds depletion of alveolar macrophages linked to bacterial super-infections
7. New methods to visualize bacterial cell-to-cell communication
8. Bacteria from Salar de Uyuni in Bolivia conceal bioplastic
9. CWRU dental researchers NIDCR grant targets oral bacteria and fetal death link
10. Genomes of cholera bacteria from Haiti confirm epidemic originated from single source
11. UT study: Chemical in antibacterial soaps may harm nursing babies
Post Your Comments:
(Date:11/17/2015)... 2015 Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" ... sale of broadly enabling, pressure cycling technology ("PCT")-based sample ... announced it has received gross proceeds of $745,000 from ... (the "Offering"), increasing the total amount raised to date ... closings are expected in the near future. ...
(Date:11/12/2015)... Nov. 12, 2015  Arxspan has entered into ... and Harvard for use of its ArxLab cloud-based ... tools. The partnership will support the institute,s efforts ... chemical research information internally and with external collaborators. ... for managing the Institute,s electronic laboratory notebook, compound ...
(Date:11/10/2015)... LONDON , Nov. 10, 2015 /PRNewswire/ ... segmented on the basis of product, type, ... segments included in this report are consumables, ... this report are safety biomarkers, efficacy biomarkers, ... in this report are diagnostics development, drug ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... -- Studies reveal the differences in species ... the way for more effective treatment for one of the ... --> --> Gum disease ... cats, yet relatively little was understood about the bacteria associated ... conducted by researchers from the WALTHAM Centre for Pet Nutrition ...
(Date:11/25/2015)... , Nov. 25, 2015 Orexigen® Therapeutics, Inc. ... participate in a fireside chat discussion at the Piper ... York . The discussion is scheduled for Wednesday, ... .  A replay will be available for ... Stilwell  , Julie NormartVP, Corporate Communications and Business ...
(Date:11/24/2015)... Calif. , Nov. 24, 2015 Cepheid ... will be speaking at the following conference, and invited ... New York, NY      Tuesday, December 1, 2015 ... New York, NY      Tuesday, December 1, 2015 ... Jaffray Healthcare Conference, New York, NY ...
(Date:11/24/2015)... 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: AEZ) ... of the Toronto Stock Exchange, confirms that as of ... corporate developments that would cause the recent movements in ... --> About Aeterna Zentaris Inc. ... Aeterna Zentaris is a specialty biopharmaceutical company engaged ...
Breaking Biology Technology: