Navigation Links
Rice study examines how bacteria acquire immunity
Date:9/15/2010

le."

The repeating sequences appear to be a kind of bookend or flag that the organism uses to determine where a snippet from a phage begins and ends. The CRISPR will often have between 30 and 50 of these snippets of phage sequences. Previous studies have found that once a bacteria has a phage sequence in its CRISPR, it has the ability to degrade any DNA or RNA that match that sequence -- meaning it can fend off attacks from any phages that have genes matching those in its CRISPR.

"What we wanted to explore was how the history of a bacterium's exposure to phages influences what's in the CRISPR," Deem said. "In other words, how is an organism's previous exposure to viruses reflected in its own genome?"

From earlier published studies, Deem and He knew that phage sequences were added to the CRISPR sequentially. So, in a CRISPR system containing 30 snippets, the newest one would be in position one, at the front of the line. In another study in 2007, researchers examining the CRISPR of whole populations of bacteria noticed some statistical irregularities. They found that the likelihood of two different organisms having the same snippet in their CRISPR increased exponentially as they progressed away from position one. So, in the organism with 30 snippets, the phage gene in position 30 was the most likely to be conserved time and again across all the bacteria in the population.

To use the power of computers to examine why this happens, Deem and He needed a mathematical description of what was happening over time to both the bacterial and phage populations. The equations they created reflect the way the bacterial and phage populations interact via the CRISPR.

"Each population is trying to expand, and selective pressure is constantly being applied on both sides," Deem said. "You can see how this plays out in the CRISPR over time. There's a diverse assortment of genes in the first spacer, but the second spacer has been in there long
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. USF receives NIH grant to study implications of maternal infection as cause of autism
2. Last strongholds for tigers identified in new study
3. VCU study: Team uncovers possible risk gene for schizophrenia
4. LiXEdrom: Innovative measuring chamber for X-ray study of liquid jets
5. OU study on genetics in fruit flies leads to new method for understanding brain function
6. BU partners in 5-year, $7.5M grant to study animal flight
7. U of I receives $1 million USDA grant to study Glossy15 in sorghum
8. Terumo Medical Corp. reports first US implant in landmark study enrolling in US and Japan
9. Study may help predict extinction tipping point for species
10. Why the biological clock? Penn study says aging reduces centromere cohesion, disrupts reproduction
11. Study: 3 out of 4 cats will wear a collar, making it worth a try
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... of people in the United States have a circulatory ... can be painful and may even require surgery in ... muscle wasting and, in turn, limb amputation. , At ... (UTHealth) Medical School, scientists tested a non-surgical preventative treatment ... was associated with increased blood circulation. Their proof-of-concept ...
(Date:7/28/2014)... have pinpointed a mechanism in part of the brain that ... it to both type 1 and type 2 diabetes. The ... Proceedings of the National Academies of Sciences . , ... a part of the hypothalamus known as the ventromedial nucleus ... glucose levels in the blood," said lead author Sabrina Diano, ...
(Date:7/28/2014)... that have seen an increase in so-called "nuisance flooding"--which ... storm drains and compromised infrastructure--are on the East Coast, ... nuisance flooding, caused by rising sea levels, has increased ... percent since the 1960s. , The report, Sea Level ... States, also finds Annapolis and Baltimore, Maryland, lead the ...
Breaking Biology News(10 mins):Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2Glucose 'control switch' in the brain key to both types of diabetes 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3
... work, home or elsewhere results in a disproportionate rise ... University of Nottingham researchers have found. , A new ... Heart Association, measured the level of cotinine in participants' ... to second-hand smoke. Cotinine is the major metabolite of ...
... Trek: The Next Generation," Geordi La Forge is a ... special implants in his eyes. While the Star Trek ... the 21st century may not have to wait that ... a University of Missouri-Columbia veterinary ophthalmologist, has been working ...
... with a knowledge of the properties and actions of enzymes, ... anti-cancer drugs originally isolated from blue-green algae. , This ... of the promising drugs for use in clinical trials. ... January issue of the journal ACS Chemical Biology, a scientific ...
Cached Biology News:Indicators for risk of heart disease are higher in passive smokers 2Indicators for risk of heart disease are higher in passive smokers 3MU researcher placing eye implants in cats to help humans see 2Turning green gunk to gold, anti-cancer gold 2
(Date:7/29/2014)... SANTA CLARA, Calif. , July 29, 2014 ... research services agreement with FORMA Therapeutics, Inc., to ... capabilities and proprietary fragment-based lead discovery platform for ... are really excited about the opportunity to work ... the fields of epigenetics and protein homeostasis. FORMA ...
(Date:7/29/2014)... CO (PRWEB) July 29, 2014 TransVac ... soiled linen collection and transport solutions for hospitals, will ... for Healthcare Engineering (ASHE) Annual Conference & Technical Exhibition ... will present its technology for making hospitals cleaner, reducing ... costs over the hospital’s life cycle. Staff will ...
(Date:7/29/2014)... , July 29, 2014  Sigma-Aldrich Corporation (NASDAQ: ... and energy use, increased its investment in Green Chemistry ... around the world last year, the Company announced Monday ... if Science Changed the World? The ... several honors for being a responsible corporate citizen, including ...
(Date:7/29/2014)... G-CON Manufacturing Inc., the standard in design ... new leadership appointment designed to drive the company’s ambitious ... , Maik Jornitz, Chief Operating Officer of G-Con Manufacturing, ... leading the pioneering company through its next phase of ... development and look forward to providing our next generation ...
Breaking Biology Technology:Nanosyn Announces Expanded Partnership With FORMA Therapeutics 2TransVac Presents Cost Saving Technology at ASHE Conference for Keeping Hospitals Cleaner 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2
... , , , , , , , , , ... , Maximum size of template , Temperature optimum , ... ment , Rnase H activity , ... , , Expand Re- , ...
... as , ... , Choose the LightCycler PCR System, the only instrument ... Central to the LightCycler , System is the LightCycler ... thermal cycler". It is a completely new integrated , ...
... , , , , , ... drastically , changed the course of modern life science research ... study and understand the crucial role of , nucleic acids ... , Roche Applied Science recognized early-on the importance of this new ...
Cached Biology Technology:Properties of Reverse Transcriptases 2The LightCycler is the only System for Quantitative PCR that is as Flexible , as, You are! 2The LightCycler is the only System for Quantitative PCR that is as Flexible , as, You are! 3The LightCycler is the only System for Quantitative PCR that is as Flexible , as, You are! 4Advantages of Roche Applied Science amplification products 2Advantages of Roche Applied Science amplification products 3
... Components in this kit are prepared ... technology. Biochains Mitochondria Isolation Kit is ... in a fast and easy way. One ... performing 100 isolations (enriching mitochondria from 10 ...
... is Tecans new Enzyme-Linked Immunosorbent Assay (ELISA) ... EVOlyzer is a dedicated EVO platform for ... washer and incubation units operated by the ... is available in three sizes - 100, ...
... are polypeptide hormones which belong to ... The TGF- superfamily is a large ... control many aspects of development, reproductive ... members incude TGF-s, bone morphogenetic proteins, ...
... Plating Beads Sterile plating in just ... rods and potentially hazardous ethanol flaming, More ... of ready-to-use sterile packaging: dispenser bottle for spreading ... Fastest and easiest way to spread ...
Biology Products: