Navigation Links
Rice University lab show how blood vessels regroup after stroke
Date:2/11/2013

ach cell is a "state machine," a unit that goes from one "state" to the next in time based on input. In the case of these endothelial cells, the input comes from vascular endothelial growth factor and/or brain-derived neurotrophic factor, proteins that encourage angiogenesis.

"There's a memory in each of these cells that helps define how they emerge into these very elaborate vasculature structures," she said. The cells that quickly differentiate into tip and stalk cells follow particular rules to advance, grow, divide and branch, depending on input from growth factors and from neighboring cells that can dictate how far and how fast they develop.

For instance, she said, in a chain of endothelial cells, a tip cell at its maximum length can only continue to migrate if the stalk cell immediately behind grows and pushes it forward. Similarly, the team set rules for branching and changes in direction, as well as an "idle" state, all based on observation of real vessel growth.

The researchers modeled a set of endothelial cells growing from a sphere and exposed them to simulated growth factors. They let them grow for what, in real life, would be a period of 24 hours, but in the computer took fractions of a second. They ran tens of thousands of simulations to see how the cells would migrate, proliferate and branch under various conditions.

The next step was to figure out which of the computer simulations matched actual behavior. Qutub's lab cultured spheres of human umbilical vein endothelial cells in collagen scaffolds, exposed them to growth factors and took microscope images as they developed networks over several days.

They compared these images with the simulations. The closest matches of which there are only a few amid thousands of simulations became the basis for a refined set of rules.

"We know how cells are connected as a function of the growth factors, and there are very distinct patterns to the way these
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. University of Alberta led research may have discovered how memories are encoded in our brains
3. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
4. Marshall University study may lead to new treatments for prostate cancer
5. University leads £6 million EU project to tackle obesity
6. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
7. Life expectancy may affect when you get married, divorced, have kids: Queens University study
8. University of Toronto biologists predict extinction for organisms with poor quality genes
9. University of Minnesota invention helps advance reliability of alternative energy
10. Israel names Tel Aviv Universitys Renewable Energy Center a Center of Research Excellence
11. University of Minnesota startup offers game-changing energy solutions that reduce CO2 emissions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... , Dec. 22, 2014 Research ... has announced the addition of the ... report to their offering. ... insight provides an overview of the global ... aims to control and monitor piracy by ...
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research and ... addition of the "Micro Market Monitor: North America ... http://photos.prnewswire.com/prnh/20130307/600769 ... grow at a CAGR of 3.6% from 2014 to ... in this market, Canada is ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... "Samsung Galaxy S5 - Home Button Synaptics Fingerprint ... http://photos.prnewswire.com/prnh/20130307/600769 ... than the iPhone 5S, Samsung introduces for the ... The Galaxy S5 home button presents ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... the October 2011 issue of Experimental Biology and ... Medical Center led by Stephen Tsang, MD, Ph.D have ... model for retinitis pigmentosa (RP) using novel bipartite gene ... by progressive degeneration of rod photoreceptors (which mediate night ...
... Advances in tissue engineering and stem cell therapies ... National Institutes of Health,s fourth Symposium on Cardiovascular Regenerative ... 30 leading researchers will share insights into the state ... sponsored by the NIH,s National Heart, Lung, and Blood ...
... Karolinska Institutet have discovered a new inherited disorder that ... adenosine kinase deficiency, is caused by mutations in the ... The findings, which are presented in the ... possible through the detailed biochemical examination of a Swedish ...
Cached Biology News:Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa 2Cell-specific mechanism-based gene therapy approach to treat retinitis pigmentosa 3NIH hosts Cardiovascular Regenerative Medicine Symposium Oct. 4-5 2New inherited neurometabolic disorder discovered 2
(Date:12/24/2014)... Sigma-Aldrich Corporation (NASDAQ: SIAL ... the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) in ... 2014, thereby completing the U.S. HSR Act antitrust ... the Company by Merck KGaA, Darmstadt, Germany.  ... to closing the transaction, which remains subject to ...
(Date:12/22/2014)... 2014   Synthetic Biologics, Inc. ... therapies for serious infections and diseases, with ... announced positive topline safety and tolerability results ... SYN-004, the Company,s investigational oral beta-lactamase enzyme ... (C. difficile) infection, antibiotic-associated diarrhea and ...
(Date:12/22/2014)... , Dec. 22, 2014  ( www.competitivehealth.com ) — ... online medical bill review and advocacy service, has signed ... FREE WellCard Savings discount health services marketplace. ... was more than they expected to pay. As part ... care costs, WellCard Savings is pleased to offer medical ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Bioject ... developer and manufacturer of needle-free injection technology, today ... with Immunomic Therapeutics, Inc. (“ITI”) for ITI to ... with its LAMP™ vaccine platform. , In ... exclusive Worldwide license to the Biojector®-2000 that triggers ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... Gastrotomy Closure Considered Largest Hurdle in Adoption of Incisionless ... Translumenal Endoscopic Surgery (NOTES), SAN CLEMENTE, Calif., Dec. ... field of Incisionless Surgery, today announced that,its EndoSurgical Operating ... a gastrotomy (an incision in the stomach wall) during,a ...
... Protocol Assessment for Reviroc, AMSTERDAM, December 19 ... completed an End of Phase II meeting for ... Reviroc is under,development for elimination of cancer cells ... end-stage blood cancer patients. The FDA,agreed that the ...
... Inc., (Amex:,ADL), today announced that its subsidiary, Jade ... nutraceutical,diagnostic, consumer healthcare and personal care products, is ... Personal Care Center in Hangzhou,China. The state-of-the-art facility ... flagship JPGreen Health and Personal Care Center., ...
Cached Biology Technology:USGI Medical Demonstrates First System for Gastrotomy Closure in NOTES 2Kiadis Pharma Reports Successful End of Phase II Meeting With FDA for Reviroc 2AMDL's First Full Service JPGreen Health and Personal Care Center Set to Open in Hangzhou, China 2