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Rice, Texas Children's team creates biocompatible patch to heal infants with birth defects
Date:12/12/2012

at it allows muscular tissue to build up and take over the mechanical process. We want apatch we can suture in that can instantly handle ventricular pressure. But if we look at it later, we want it to look like normal tissue," he said.

Years of testing await the researchers before human trials can begin, but Jacot and his team are already looking ahead to the possibilities their success could offer. They hope to find a way to mix stem cell-derived heart cells from a patient into the hydrogel at the beginning of the process; stem cells may be drawn from several possible sources, including amniotic fluid routinely drawn from the newborn's mother, the subject of ongoing study by Jacot's lab. The cells would make a patch genetically identical to the child that could be implanted shortly after birth.

"If we can make a patch that works immediately," Jacot said, "one that contracts and conducts and has living cells and grows with the patient, what other surgeries can we do that nobody can do now?"


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Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

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