Navigation Links
Rice, Texas Children's team creates biocompatible patch to heal infants with birth defects
Date:12/12/2012

sue. And having dead tissue means the heart produces less force, so it's not surprising that children with these types of repairs are more at risk for developing heart failure, arrhythmias and fibrillation.

"What we're making can replace current patches in an operation that surgeons are already familiar with and that has a very high short- and medium-term success rate, but with long-term complications," he said.

A better scaffold would have to perform many functions perfectly. It must be strong enough to withstand the pressures delivered by a beating heart yet flexible enough to expand and contract; porous enough to allow new heart cells to migrate, make connections and excrete their own natural scaffold to replace the patch; and tough enough to handle sutures but still be able to biodegrade over just the right amount of time for natural tissue to take over.

The sandwich the researchers created seems to fill the bill on all counts. In the middle is a self-assembled polycaprolactone (PCL) polymer that hardens into a tough but stretchable ribbon. Mixing two types of PCL with different molecular weights allows tiny pores to form along the rough surface. The "bread" is a hydrogel made from a 50/50 mixture of gelatin and chitosan, a widely used material made from the shells of crustaceans like shrimp.

Heart cells cultured on the hydrogel surface were able to thrive and formed networks and ultimately beat. Though cells could not attach to the surface or pass through the pores of the PCL, the pores do allow nutrients to migrate from one side to the other, Jacot said. They also allow the hydrogel to hold on to the PCL core.

The lab tested the biodegradable qualities of the PCL and found that over 50 days, about 15 percent dispersed, leaving a ragged sheet. "It degrades in water," Jacot said. "If it's in the body, it will degrade, but it will be very slow, over the course of months.

"It should be stable for long enough th
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Rice, MD Anderson scientists probe mystery of operon evolution
2. Monarch butterflies down again this year as decline continues, says Texas A&M expert
3. NASAs Landsat satellites see Texas crop circles
4. NASA satellite measurements imply Texas wind farm impact on surface temperature
5. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
6. Diet of early human relative Australopithecus shows surprises, says Texas A&M researcher
7. Mining cleanup benefits from Texas A&M expertise
8. University of Texas Medical Branch selected to manage Center for Polar Medical Operations
9. NSBRI renews space life sciences graduate programs at MIT, Texas A&M
10. BP Biofuels, Texas AgriLife Research sign agreement to advance biofuel feedstock development
11. Controlling gait of horses may be possible, says key study from Texas A&M
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... 2, 2015 In the ... far outperforms the strongest competitors, showing outstanding performance ... the system is capable of a throughput of ... up to be ten times faster than most ... performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
(Date:4/2/2015)... 2015 According to preliminary estimates ... somewhat higher than 125 MSEK. This exceeds the guidance ... that revenues for Q1 2015 would be in line ... Q4 2014. The operating result for the first quarter ... interim report will as previously communicated be published on ...
(Date:4/1/2015)... , Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... smart wallets is underway to early access pre-order customers. ... includes usage at retail outlets including Walmart, Target, AT&T, ... report Wocket was accepted at all outlets and very ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... 2010 ... ... ... Results are keyed by longUrl, so we need to grab the first one. for (var r in data.results) { ...
... mice that can "smell" light, providing a potent new tool ... olfaction. The work, described this week in the journal ... of smell and of complex perception systems that do not ... makes intuitive sense to use odors to study smell," says ...
... YORK, Sept. 21 Global Rainmakers, Inc. (GRI), ... and advanced R&D laboratory, today announced the appointment of ... be responsible for overseeing firm operations as it ... Demitrieus, 62, comes to GRI with ...
Cached Biology News:Almac has Successful MHRA Inspection at its Clinical Services UK Site 2Almac has Successful MHRA Inspection at its Clinical Services UK Site 3Almac has Successful MHRA Inspection at its Clinical Services UK Site 4Almac has Successful MHRA Inspection at its Clinical Services UK Site 5Almac has Successful MHRA Inspection at its Clinical Services UK Site 6Almac has Successful MHRA Inspection at its Clinical Services UK Site 7Almac has Successful MHRA Inspection at its Clinical Services UK Site 8Mice that 'smell' light could help us better understand olfaction 2Global Rainmakers Appoints James M. Demitrieus as Chief Operating Officer 2Global Rainmakers Appoints James M. Demitrieus as Chief Operating Officer 3
(Date:5/4/2015)... , May 4, 2015   Sentrian ™, ... hospitalizations, has teamed with the Scripps Translational Science ... technology on 1,000 patients with chronic obstructive pulmonary disease ... Americans and is the nation,s third leading cause of ... CareMore Health System , a wholly owned subsidiary ...
(Date:5/1/2015)... May 1, 2015 Pfenex Inc. (NYSE ... the development of biosimilar therapeutics including high value ... its first quarter 2015 financial results will be ... open of market. At 8:30 am Eastern Time, Pfenex ... the financial results and provide a business update. A ...
(Date:5/1/2015)... , May 1, 2015 ... "Antibody Production Market by Product (Equipment, Consumables), by Type ... Companies, Diagnostic Labs, Research Institutes) - Analysis & ... report studies the global Antibody Production Market for ... market is expected to reach $2.572 Billion by ...
(Date:4/30/2015)... Cytokinetics, Incorporated (Nasdaq: CYTK) reported total research ... $4.4 million, compared to $8.0 million during the same period ... was $8.9 million, or $0.23 per basic and diluted share. ... period in 2014, of $8.7 million, or $0.27 per basic ... cash equivalents and investments totaled $117.5 million. , "During ...
Breaking Biology Technology:CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 2CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 3CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 4CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 5Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Antibody Production Market worth $2.572 Billion by 2019 2Antibody Production Market worth $2.572 Billion by 2019 3Antibody Production Market worth $2.572 Billion by 2019 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 3Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 5Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 6Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 7Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 8
... Security Research Consortium held an organizational meeting last week ... bring classified research to Wisconsin institutions. , ,Tom Hefty, ... president of the board of directors. He is now ... , Paul Peercy , dean of the UW-Madison ...
... There are few better ways to promote your business than ... web site. , ,Good content attracts good traffic. , ,On ... on the Internet, according to the PEW Internet and ... activities include getting news and finding information via search engines. ...
... reflection, and this one is no different. These last 12 months ... doubt look back on 2005 and pronounce it the year the ... of things, the previous four years were a standing eight count, ... like hell and a lot was lost on bad bets, but ...
Cached Biology Technology:The write stuff: marketing with articles 2The write stuff: marketing with articles 3The write stuff: marketing with articles 42005: the year of the comeback 22005: the year of the comeback 3
Homo sapiens HCLS1 associated protein X-1 Antigen: Recombinant Protein...
See product name for description....
Amino Acid Analysis is performed using ion-exchange separation of the amino acids from acid hydrolysates, followed by ninhydrin detection. Typical quantities required are 0.1 to 0.5 mg, depending on...
...
Biology Products: