Navigation Links
Rice, MD Anderson researchers win NIH grant to study protein networks
Date:8/26/2013

are more prone to turn cancerous than others.

The research will first focus on what are known as master cytoskeletal regulatory proteins (CRPs) that control how cells take shape and move. The overexpression of these proteins is known to be associated with poor prognosis for some cancer patients, but the researchers said their workings remain largely unknown.

Balzsi's lab has developed the ability to prompt the expression of genetically modified proteins that give the researchers a level of control over CRPs with minimal disruption of other cell functions. This lets the researchers design experiments to see how the systems inside cells respond to stress.

Diehl is most interested in a CRP called "IQGAP." "It both tunes cell-signaling responses and is involved in controlling proteins that regulate the cytoskeleton," he said. "It's at the junction of those two behaviors." By perturbing the regulatory network through modified IQGAP, "we can look at the network response and correlate that with cellular behavior. It's a very powerful approach that can be applied to many molecular and cellular processes."

Diehl's lab will view those processes with a multiplexed "super resolution" imaging technique that lets researchers see individual protein molecules inside cells in three dimensions. That will allow them to identify multiple proteins in a cell, perhaps hundreds, at once. Key to the technique is the ability to combine images that focus on different target proteins into a comprehensive picture of cellular structure.

"We have developed erasable molecular imaging probes for these types of studies," Diehl said. Tagging proteins with fluorescent dyes allows researchers to "see" them, but current microscopes are limited to only a few color channels. With the ability to tag, erase and retag proteins, the Diehl lab can capture much more information from snapshots of a cell taken before and after perturbation.

Qutub's lab analyze
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Rice, MD Anderson scientists probe mystery of operon evolution
2. Rice, Texas Childrens team creates biocompatible patch to heal infants with birth defects
3. UT MD Anderson scientists uncover the nuclear life of actin
4. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
7. UNH researchers find African farmers need better climate change data to improve farming practices
8. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
9. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
10. Researchers print live cells with a standard inkjet printer
11. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/143028 for MINIATURE, MULTI-PURPOSE ... TRANSFER  NXT-ID introduces a new revolutionary ... patent surrounds the use of miniature antenna modules ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... DCResearchers at the Center for Neuroscience Research ... two major types of signaling pathways activated during brain ... Notch pathwayoperate together to determine how many and which ... repair in developing and adult brains. This knowledge may ...
... Cancer Epidemiology (LACE) study, 1,897 participants diagnosed with early-stage ... average 2 years post-breast cancer diagnosis were evaluated for ... and death. The women, who were generally light ... The study reported an increase in risk of ...
... there,s a new reason to grab a glass of milk when ... American Journal of Clinical Nutrition . In a 2-year weight loss ... milk. Israeli researchers found that adults who drank the most milk ... levels at 6 months, lost more weight after 2 years than ...
Cached Biology News:Discovery of key pathway interaction may lead to therapies that aid brain growth and repair 2New study finds milk drinkers may have a healthy weight advantage 2
(Date:5/5/2015)... LOS ANGELES , May 5, 2015 ... and pioneer in providing on-demand access to scientific, technical ... purchasing agreement with the Association of Southeastern Research ... of 38 research libraries located across 11 southeastern states. ... developing innovative and collaborative programs to address the continually ...
(Date:5/5/2015)... BELLINGHAM, Washington, and WASHINGTON, D.C., USA (PRWEB) May 05, ... today on U.S. export regulations covering a wide range ... the industry say are hampering global competitiveness of U.S. ... will host a webinar on 12 May ... Category XII, which governs the commodities covered by International ...
(Date:5/5/2015)... , May 05, 2015 Research and Markets ... addition of the "Clinical Laboratory, Molecular Diagnostics ... 2015 to 2019 - Europe Version" report ... especially in the area of molecular diagnostics and ... and evolving world market that is moving out ...
(Date:5/5/2015)... , May 5, 2015   Tocagen Inc. ... David R. Parkinson , M.D., a venture ... appointed to the board of directors of Tocagen. ... experience in oncology clinical development, including leading clinical ... global approvals of the cancer therapeutics Gleevec®, Femara®, ...
Breaking Biology Technology:Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 4Comments needed now from photonics industry on revisions of U.S. export rules 2Comments needed now from photonics industry on revisions of U.S. export rules 3Comments needed now from photonics industry on revisions of U.S. export rules 4European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 4
... Biologics CapabilitiesST. LOUIS, Jan. 29 ... member of the Sigma-Aldrich(R) group (Nasdaq: ... has commenced operations at its 7,000 sq. ft. ... adjacent to the Company,s existing flagship viral substance ...
... Sangamo BioSciences, Inc. (Nasdaq: SGMO ) ... quarter and year-end 2008 financial results on Wednesday, February ... will be followed by a conference call at 5:00 ... via telephone and webcast. During the conference call, the ...
... Good bugs apparently are recession-proof. , ... in growing bacteria for cleaning and for agriculture reports that ... -- despite the nation,s economic problems. , ... executive vice president of Osprey Biotechnics, which is headquartered north ...
Cached Biology Technology:SAFC Pharma Augments Assay Development Capabilities 2SAFC Pharma Augments Assay Development Capabilities 3SAFC Pharma Augments Assay Development Capabilities 4Sangamo BioSciences Announces Fourth Quarter and Year-End 2008 Conference Call and Webcast 2Sangamo BioSciences Announces Fourth Quarter and Year-End 2008 Conference Call and Webcast 3
... systems provide automated, higher throughput screening of ... tubes. This flexible sample format makes the ... basic research, target validation, assay development, and ... the Guava PCA-96 uses a green laser ...
... 250 g monoclonal antibody irreversibly crosslinked ... ~13 g of PDH complex from heart ... bovine heart mitochondria for control immunocapture. ,The ... isolation of PDH from small amounts of ...
... a protein into cells permits studies of ... apoptotic pathways, and transcription factor-mediated gene regulation. ... effects of a specific protein in a ... directly into the cell. ProteoJuice Protein Transfection ...
... SE flow cytometry system is the superior ... over 25 years, BD cell sorters have ... in leading university, pharmaceutical, and biotechnology research ... the research demands of today, we have ...
Biology Products: