Navigation Links
Rice, MD Anderson researchers win NIH grant to study protein networks
Date:8/26/2013

are more prone to turn cancerous than others.

The research will first focus on what are known as master cytoskeletal regulatory proteins (CRPs) that control how cells take shape and move. The overexpression of these proteins is known to be associated with poor prognosis for some cancer patients, but the researchers said their workings remain largely unknown.

Balzsi's lab has developed the ability to prompt the expression of genetically modified proteins that give the researchers a level of control over CRPs with minimal disruption of other cell functions. This lets the researchers design experiments to see how the systems inside cells respond to stress.

Diehl is most interested in a CRP called "IQGAP." "It both tunes cell-signaling responses and is involved in controlling proteins that regulate the cytoskeleton," he said. "It's at the junction of those two behaviors." By perturbing the regulatory network through modified IQGAP, "we can look at the network response and correlate that with cellular behavior. It's a very powerful approach that can be applied to many molecular and cellular processes."

Diehl's lab will view those processes with a multiplexed "super resolution" imaging technique that lets researchers see individual protein molecules inside cells in three dimensions. That will allow them to identify multiple proteins in a cell, perhaps hundreds, at once. Key to the technique is the ability to combine images that focus on different target proteins into a comprehensive picture of cellular structure.

"We have developed erasable molecular imaging probes for these types of studies," Diehl said. Tagging proteins with fluorescent dyes allows researchers to "see" them, but current microscopes are limited to only a few color channels. With the ability to tag, erase and retag proteins, the Diehl lab can capture much more information from snapshots of a cell taken before and after perturbation.

Qutub's lab analyze
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Rice, MD Anderson scientists probe mystery of operon evolution
2. Rice, Texas Childrens team creates biocompatible patch to heal infants with birth defects
3. UT MD Anderson scientists uncover the nuclear life of actin
4. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
7. UNH researchers find African farmers need better climate change data to improve farming practices
8. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
9. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
10. Researchers print live cells with a standard inkjet printer
11. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... Research and Markets( ... "Biometrics for Banking; Market & Technology Analysis, ... their offering. The adoption for banking ... and the forecast is that by 2020 it ... involved in delivering biometric systems to the banking ...
(Date:7/8/2015)... YORK , July 8, 2015 Summary ... globally, and the fourth most fatal, with a mortality ... The poor prognosis of pancreatic cancer patients has highlighted ... treatment, which is not being met by the current ... an array of products with varying molecule types and ...
(Date:7/8/2015)... Florida , July 8, 2015 ... evolving as this summer,s must have products such as wearables, ... demand as popularity for biometrics based devices continues to rapidly ... NXT-ID, Inc. (NASDAQ: NXTD ), Google Inc. (NASDAQ: ... (NYSE: FIT ), GoPro, Inc. (NASDAQ: GPRO ) ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
... release is available in German . ... establishment of twelve new Collaborative Research Centres (CRC) beginning 1 ... at its spring meeting in Bonn. The new CRCs will ... 112 million euros (including a 20% programme allowance for indirect ...
... HOUSTON -- (May 28, 2010) -- A team ... critical effects at the heart of the latest high-temperature ... it. In new research appearing online today in ... University-led team offers new evidence about the quantum features ...
... 27, 2010 Ardipithecus ramidus a purported ... the Year" is coming under fire from scientists who ... there were dense woodlands at the African site where the ... abundant evidence for open savanna habitats," says University of Utah ...
Cached Biology News:DFG approves 12 new collaborative research centers 2DFG approves 12 new collaborative research centers 3DFG approves 12 new collaborative research centers 4DFG approves 12 new collaborative research centers 5DFG approves 12 new collaborative research centers 6Zeroing in on quantum effects 2Zeroing in on quantum effects 3Out of the woods for 'Ardi' 2Out of the woods for 'Ardi' 3Out of the woods for 'Ardi' 4
(Date:7/29/2015)... Research and Markets ... the "Global Biosimilars Market, 2015 - 2025" ... Global Biosimilars Market, 2015 - 2025, report provides ... market. With the blockbuster biologics losing patent protection ... are being viewed as viable substitutes to the ...
(Date:7/29/2015)... Inc., an early stage biotech startup based on perinatal ... the Musculoskeletal Transplant Foundation of Edison NJ ... round of development of the proprietary AmnioCept™ product line ... AmnioChor,s technology allows cryopreservation of the amniotic membrane of ... those tissues. Amnion is a well-established source of multipotent ...
(Date:7/29/2015)... 2015  Pfenex Inc. (NYSE MKT: PFNX) announced today ... released on Thursday, August 13, 2015, before the open ... will host a conference call to discuss the financial ... outlining the financial results and business update will be ... call 1-866-376-8058 (US) or 1-412-542-4131 (international) and reference Pfenex ...
(Date:7/29/2015)... ... July 29, 2015 , ... The third Medical Innovation Impact Index (MI3) Alert ... particular, drug/device combinations. The current system received a score of 0 (range -10 to ... Innovation (iPCI) of Fairleigh Dickinson University’s ( FDU ) Rothman Institute of Innovation ...
Breaking Biology Technology:Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3The Musculoskeletal Transplant Foundation Agrees to Invest in AmnioChor 2Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3
... turn a profit, and it operates in a biotech space where ... research tool manufacturer NimbleGen Systems to file an initial ... bit of evidence that the Wisconsin biotech company is going places. ... and visibility for NimbleGen, which saw its revenues grow to $13.5 ...
... second time this year, a tech-based company in Wisconsin has ... public. Called an initial public offering, this kind of business ... who are directly involved, but to others who may follow ... company, has filed papers with the Securities and Exchange ...
... Wis . - Every surgical operation requires proper wound ... and a Madison start-up business has received a $100,000 ... , , Nerites Corp ., which develops tissue repair ... received a $100,000 Small Business Innovation Research ...
Cached Biology Technology:IPO-bound NimbleGen traveling in fast company 2IPO-bound NimbleGen traveling in fast company 3IPO-bound NimbleGen traveling in fast company 4Wisconsin IPOs are a harbinger of growing tech economy 2Wisconsin IPOs are a harbinger of growing tech economy 3
... Lines stably express the regulatory GeneSwitch ... is functionally tested for induction ability ... control vector pGene/V5-His/lacZ and by assaying ... mifepristone (Figure 1). These cell lines ...
... for 10 separate biopanning experiments, complexity ... gIII Sequencing Primer (100 pmol), for ... Primer (100 pmol), for automated DNA ... Control target (Streptavidin) and Elutant (Biotin), ...
... Materials for 15-20 enhancements ... TM Western Blot Signal Enhancement System is designed ... and is an excellent tool for evaluating proteins with ... used to pre-treat membrane prior to blocking the membrane; ...
... Re-Blot Western Blot Recycling Kit is ... Western blots that have been developed ... other isotopes. It is not recommended ... 4-chloronapthol, etc.), as it is not ...
Biology Products: