Navigation Links
Riboswitches in action
Date:11/4/2013

A cell is a complex environment in which substances (metabolites) must maintain a correct state of equilibrium, which may vary depending on specific needs. Cells can maintain the proper concentrations of metabolites by regulating gene protein encoding through specific "switches", called riboswitches, which are able to block or activate protein synthesis. The precise mechanism by which these short strands of RNA carry out this function is still poorly understood. However, a study conducted by SISSA scientists Giovanni Bussi, Francesco Colizzi and Francesco De Palma and published in the journal RNA, now provides some important insights.

A riboswitch is contained in a strand of messenger RNA, an RNA fragment that acts as a sort of template that "prints" the proteins that are needed for cell metabolism. However, unlike the rest of the messenger RNA unit, riboswitches don't actually encode any portion of the protein (i.e., they form part of what geneticists call non-coding RNA) but they serve to activate or deactivate the protein printing process and are located, in bacteria, in a stretch preceding the coding sequence. Scientists know that this switching action is made possible by a change in shape, which occurs when a part of the riboswitch (the aptamer) binds to a molecule in the cell environment which acts as a signal. Bussi and colleagues used computer simulations to reproduce the dynamics of the process and understand how binding to the metabolite brings about the change in shape.

More specifically, Bussi and colleagues simulated the riboswitch that uses an adenine molecule as a signal, to regulate the gene expressing a protein involved in the metabolism of adenine itself. Their findings clarify how adenine stabilizes the active form of the riboswitch (the one triggering protein synthesis) to the detriment of the inactive conformation. "We used molecular dynamics as a kind of 'virtual microscope' with which we observed the workings of the p
'/>"/>

Contact: Federica Sgorbissa
pressroom@sissa.it
39-040-378-7644
International School of Advanced Studies (SISSA)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Gene-diet interaction may help explain link between eating meat & colorectal cancer risk
2. Berkeley Lab researchers get a detailed look at a DNA repair protein in action
3. Stanford scientists use Flickr photos to assess value of natural tourist attractions
4. Grassroots action in livestock feeding to help curb global climate change
5. Personality interactions between animals may dictate outcomes in the wild
6. Better insight into molecular interactions
7. Robbins Geller Rudman & Dowd LLP and Scott+Scott, Attorneys at Law, LLP Announce Proposed Settlement of Class Action in the Pacific Biosciences Securities Litigation
8. Nanotechnology helps track and improve drug action in pancreatic cancer
9. First dual-action compound kills cancer cells, stops them from spreading
10. UCLA life scientists present new insights on climate change and species interactions
11. Scientists discover how brains auditory center transmits information for decisions, actions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Riboswitches in action
(Date:11/11/2014)... Nov. 11, 2014  Forensicon, Inc., a ... pleased to announce the promotion of Yaniv Schiff ... Digital Forensics. In Schiff,s new role as Director, he ... of digital forensics examiners and provide leadership within the ... - http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined ...
(Date:11/7/2014)... professor, biomedical engineering, in the Grove School of ... have identified a molecule that could lead to ... forms of breast cancer. , Triple negative breast ... to aggressive proliferation and metastasis and a lack ... discovered the overexpression of intercellular adhesion molecule-1 (ICAM-1) ...
(Date:11/7/2014)... November 6, 2014 Leading Biometric companies ... mobile security revolutionizing online transactions.  Companies in focus today are: ... (NYSE: BABA ), Google Inc. (NASDAQ: ... Inc. (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: ... and NXTDW), a biometric authentication company focused on the growing ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... times stronger than steel, weighs one-sixth as much and can ... The answer is a carbon nanotube -- and a new ... nanomaterials snap when subjected to ultrasonic vibrations in a liquid. ... but not bend, does not hold at the micro- and ...
... The Philippines, scientists from 21 research institutions from Germany, ... several concerns on the future of the rice ecosystems ... the framework of the international project LEGATO ... arising from various aspects of global change. "Threats ...
... used metal complexes to modify peptide hormones. In the ... report for the first time on the three-dimensional structure ... have laid the molecular foundation for the development of ... of Chemistry and Biochemistry at the Ruhr-University. The team ...
Cached Biology News:Tiny bubbles snap carbon nanotubes like twigs 2Tiny bubbles snap carbon nanotubes like twigs 3Sustainability of rice landscapes in South East Asia threatened 2A new avenue to better medicines: Metal-peptide complexes 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... -- (May 30, 2010) -- In a development that ... researchers from Rice University and the Technion-Israel Institute of ... quantities of one-atom-thick sheets of carbon called graphene. ... Nature Nanotechnology . When stacked together, graphene sheets ...
... ... a detailed “road map” defining all aspects of the future 110-acre Livermore Valley Open ... site planning, and real estate development planning, as well as maintenance and operations planning. ... San Francisco, ...
... May 28 BioSpace.com is putting the nation,s Middle-Atlantic region on ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20040907/CLTU006LOGO ) , ... The leading career Web site for the life sciences ... edition and highlighting multiple companies within Washington D.C. , Delaware , ...
Cached Biology Technology:Liquid method: pure graphene production 2Flad Architects Awarded Livermore Valley Open Campus Master Plan 2BioSpace Launches 10th Campaign Map for the Mid-Atlantic 2BioSpace Launches 10th Campaign Map for the Mid-Atlantic 3
... is a high performance spectral scanning ... incubator. With the advanced SkanIt Software ... for drug discovery assay development. Varioskan ... intensity, time-resolved fluorescence and photometric assays ...
Strip Removal Tool 25/Box...
Oven mesh sheets, large, 23 x 23cm, pack of 5...
... Lambda Protein Phosphatase ... Mn2+-dependent protein phosphatase with ... threonine and tyrosine residues. ... amino-acid product of the ...
Biology Products: