Navigation Links
Rhythmic breathing adapts to external beat through 'brain calculus'
Date:9/11/2007

CAMBRIDGE, Mass, Sept. 12, 2007 The same kind of learning that allows humans to get used to a subtle touch or persistent odor may also help human vital signs adapt to medical interventions such as mechanical ventilation.

The team, led by Chi-Sang Poon, a research scientist at the Harvard-MIT Division of Health Sciences and Technology (HST), suggests that this innate ability to adapt, called nonassociative learning, could be leveraged to design more effective and less costly artificial respirators.

In a study published on September 12 in the online, open-access journal PLoS ONE, Poon examined rats under mechanical ventilation to see how they applied different forms of nonassociative learning to adapt to the rhythm imposed by the respirator.

Existing designs of respirators do not consider the adaptive nature of breathing in their design. Some respirators ignore the patients natural rhythm and pump air in and out of the lungs on set intervals. Doctors often must sedate or paralyze patients to prevent them from fighting this unfamiliar rhythm. Other designs rely entirely on the patient to trigger the airflow. These systems, however, are costly and tend to be unreliable for weak patients such as newborns or those in critical care.

Poons experiment suggests, however, that if a doctor takes the patients natural breathing rhythm into account and sets the ventilators rhythm in that same range, the patient will adapt and synchronize with the ventilator. This new approach could minimize the need for induced sedation or paralysis.

We have intrinsic nonassociative learning capabilities, called habituation and desensitization, that make up for changes in the spontaneous rhythm due to artificial lung inflation, says Poon.

Nonassociative learning is a basic and familiar animal behavior. For instance, roses smell heady and intense at first, but minutes later they lose their affect due to habituation. The body learns to
'/>"/>

Contact: Elizabeth Dougherty
bethd@mit.edu
617-324-5398
Public Library of Science
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
2. How exactly does the brain control breathing?
3. Prenatal nicotine exposure reduces breathing response of newborns...
4. Vampire bats recognise their preys breathing
5. Breathing easy: When it comes to oxygen, a bugs life is full of it
6. Retina adapts to seek the unexpected, ignore the commonplace
7. Asexual worm quickly adapts to soil contamination
8. Termites feed through good vibrations
9. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
10. Breakthrough Microarray-based Technology for the Study of Cancer
11. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/15/2008)...,, A team of Penn State researchers has deve...tigate the organization and function of two of the... the cytoplasm--the gelatinous fluid that surround...lead to the creation of new drugs that take advant...the development of diseases. The team,s findings ...
(Date:5/15/2008)..., CAMBRIDGE, Mass.--MIT engineers have improved t...han 50 percent through technology that could help ...ces find a much broader market, particularly in po...e work is also considerably less expensive than it... advantages. , Our goal is to replace traditiona...
(Date:5/15/2008)..., Venus Express has detected the molecule hydroxy...tion gives scientists an important new tool to unl...ydroxyl, an important but difficult-to-detect mole...h. It has been found in the upper reaches of the V... by Venus Expresss Visible and Infrared Thermal Im...
(Date:5/14/2008)..., PHILADELPHIA Genetic differences may explain t...n men compared with Hispanic men, which could help...the disease, according to a paper published in the...a journal of the American Association for Cancer R... assessing risk for prostate cancer is the prostat...
Breaking Biology News(10 mins):Simple model cell is key to understanding cell complexity 2MIT creates new material for fuel cells 2MIT creates new material for fuel cells 3Key molecule discovered in Venus's atmosphere 2Genes may play role in risk assessment for prostate cancer among Hispanics and caucasians 2Climate influence on deep sea populations 1916 1Climate influence on deep sea populations 1916 2Stereotaxis Provides Fourth Quarter 2007 Revenue Outlook 9588 1Stereotaxis Provides Fourth Quarter 2007 Revenue Outlook 9588 2Stereotaxis Provides Fourth Quarter 2007 Revenue Outlook 9588 3Stereotaxis Provides Fourth Quarter 2007 Revenue Outlook 9588 4Wisconsin Physicians Service Insurance Corporation Files Suit Against Aurora Health Care and HealthEOS 9583 1Wisconsin Physicians Service Insurance Corporation Files Suit Against Aurora Health Care and HealthEOS 9583 2AHRQ Releases Consumer Financial Incentives Guide for Employers and Other Health Care Purchasers 9578 1AHRQ Releases Consumer Financial Incentives Guide for Employers and Other Health Care Purchasers 9578 2AHRQ Releases Consumer Financial Incentives Guide for Employers and Other Health Care Purchasers 9578 3
...as discovered that cannabinoids can cause some whi... the sites of infection and inflammation. These f...urnal of Biological Chemistry, could have potentia...y drugs. , The cannabinoids are a group of chemica...o and activate the body,s cannabinoid receptors. ...
... Illinois at Urbana-Champaign who recently reporte... sensors in living cells now say the tiny tubes ca...ial applications for the new sensors range from ra...mpler and more efficient forensic identification. ...mical and biomolecular engineering professor Micha...
...York have played a crucial role in developing a wa... explosives. , The research, by a team led by Prof...tural Products) in the University,s Department of ...n trees and plants into highly-effective pollution...ature Biotechnology, , Decades of military activi...
...ollege London) scientists has designed a new drug ...otein (CRP), a protein that contributes to tissue ..., published in the journal Nature, suggest that ta...rm clinical benefits following a heart attack. , C...d but its concentration increases sharply in almos...
Other Biology News:Detection of DNA on nanotubes offers new sensing, sequencing technologies 2York researchers develop pollution-busting plants to clean up contaminated land 2New drug could reduce tissue damage after heart attack 2
(Date:5/16/2008)...all/ -- Wyeth (NYSE: WYE ),announced today that i...h,Healthcare Conference on Wednesday, May 21, 2008...will be Greg Norden, Senior Vice President and,Chi...n will be webcast live for investors at, http://ww...e conference., Wyeth is one of the world,s larges...
(Date:5/16/2008)...- George Abercrombie, president,and chief executiv...200,Fort Worth business leaders today at a Rotary ...andemic flu presents businesses with challenges,un...preparedness plans., "While businesses are all to...such as floods or tornadoes," according to Abercro...
(Date:5/16/2008)...metrix Institute (, http://www.metametrixinstitute...ory Evaluations for Integrative and Functional Med...S. Lord and J. Alexander Bralley.,This book follow...tory,Evaluations in Molecular Medicine, published ...of Metametrix Inc., a leader in nutritional and,me...
(Date:5/16/2008)...herapeutics Corporation,announced today that it ha...welve-week Phase IIb trial with oral larazotide ac...ion, for the treatment of patients with active,cel...zed, double-blind,placebo-controlled study will e...fety and tolerability of larazotide acetate in 106...
Breaking Biology Technology:CEO Addresses Fort Worth Business Leaders About Developing Pandemic and Business Continuity Plans 2CEO Addresses Fort Worth Business Leaders About Developing Pandemic and Business Continuity Plans 3Introducing Laboratory Evaluations for Integrative and Functional Medicine 2Alba Therapeutics Announces the Enrollment and Randomization of the First Patient in the Phase IIb Clinical Trial for Larazotide Acetate (AT-1001) for the Treatment of Active Celiac Disease 2Alba Therapeutics Announces the Enrollment and Randomization of the First Patient in the Phase IIb Clinical Trial for Larazotide Acetate (AT-1001) for the Treatment of Active Celiac Disease 3
..., , , , , , , The Fa..., , , FastStart Taq DNA Polymerase, a ...e for hot start PCR, was introduced,in 2000. Bas...t Taq DNA Polymerase has proven to be: The most r... , , , Even the most challenging...
..., , , , , , , Specific...transfections , , First, verify th...l line. Also, determine the ratio of DNA ,to FuG...ENE 6 Reagent) that ,provides good expression le... ,DNA / FuGENE 6 Reagent ratio takes into accoun...
..., , , , , , , Cells ,... Keep an eye on your cells; ensure they are in ...protocol for optimal cell density from the beginni..., , , Dividing versus Non-dividing ...essible for uptake and expression of, forei...
... , , Agencourt offers whole genome servic...me projects from shotgun library construction , .... Our personal project managers , consult w...t their specific , project goals and are av.... , Our efforts to increase quality while r...
Other Biology Technology:Challenge the Performance of Your Hot-Start PCRs,with FastStart Taq DNA Polymerase and,the Novel FastStart High Fidelity PCR System 2Uses and Applications of FuGENE 6 Transfection Reagent 2General Considerations for Successful Transfection Experiments 2WHOLE GENOME SEQUENCING 2WHOLE GENOME SEQUENCING 3
Scotch-Brite pads from Thermo Scientific
...ructure has been determined, the challenge is to c...dience of scientists, educators and students. Curr...semination over the Internet, either via online jo...literature has the advantage of wide acceptance an...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi
Rotor for four tube-loaded buckets; ma RCF 2550g; sold without buckets
Biology Products: