Navigation Links
Rhythmic breathing adapts to external beat through 'brain calculus'
Date:9/11/2007

CAMBRIDGE, Mass, Sept. 12, 2007 The same kind of learning that allows humans to get used to a subtle touch or persistent odor may also help human vital signs adapt to medical interventions such as mechanical ventilation.

The team, led by Chi-Sang Poon, a research scientist at the Harvard-MIT Division of Health Sciences and Technology (HST), suggests that this innate ability to adapt, called nonassociative learning, could be leveraged to design more effective and less costly artificial respirators.

In a study published on September 12 in the online, open-access journal PLoS ONE, Poon examined rats under mechanical ventilation to see how they applied different forms of nonassociative learning to adapt to the rhythm imposed by the respirator.

Existing designs of respirators do not consider the adaptive nature of breathing in their design. Some respirators ignore the patients natural rhythm and pump air in and out of the lungs on set intervals. Doctors often must sedate or paralyze patients to prevent them from fighting this unfamiliar rhythm. Other designs rely entirely on the patient to trigger the airflow. These systems, however, are costly and tend to be unreliable for weak patients such as newborns or those in critical care.

Poons experiment suggests, however, that if a doctor takes the patients natural breathing rhythm into account and sets the ventilators rhythm in that same range, the patient will adapt and synchronize with the ventilator. This new approach could minimize the need for induced sedation or paralysis.

We have intrinsic nonassociative learning capabilities, called habituation and desensitization, that make up for changes in the spontaneous rhythm due to artificial lung inflation, says Poon.

Nonassociative learning is a basic and familiar animal behavior. For instance, roses smell heady and intense at first, but minutes later they lose their affect due to habituation. The body learns to
'/>"/>

Contact: Elizabeth Dougherty
bethd@mit.edu
617-324-5398
Public Library of Science
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
2. How exactly does the brain control breathing?
3. Prenatal nicotine exposure reduces breathing response of newborns...
4. Vampire bats recognise their preys breathing
5. Breathing easy: When it comes to oxygen, a bugs life is full of it
6. Retina adapts to seek the unexpected, ignore the commonplace
7. Asexual worm quickly adapts to soil contamination
8. Termites feed through good vibrations
9. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
10. Breakthrough Microarray-based Technology for the Study of Cancer
11. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... honored Clemson professor Rajendra Singh Thursday as a ... and expand solar deployment in the residential, commercial ... Banks Professor of Electrical and Computer Engineering and ... considered a local hero leading the charge across ... in solar power and driving policy changes at ...
(Date:4/17/2014)... honeybees in Europe, Asia and the United States are ... be impacting native honeybee populations at this time, according ... include including Nosema microsporidia and Varroa ... resilient to these invasive pests, which suggests to us ... Asia and the United States currently are not necessary ...
(Date:4/17/2014)... Researchers in France have hit on a novel ... receive the correct and most effective treatment possible., ... the western and developing world. If left untreated, ... to renal failure and other complications. In many ... problem. Clearly a more effective pathological approach to ...
Breaking Biology News(10 mins):White House honors Clemson professor as 'Champion of Change' for solar deployment 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... throughout the world and ensuring safe water supplies would do ... any other possible measure, according to an analysis released today ... water and sanitation reduces poverty in three ways. ... entrepreneurs; , Significant savings are achieved in the ...
... Researchers have discovered a mechanism for the rapid growth seen ... The tumors, which are made up of proliferating blood ... descent, with girls more frequently afflicted than boys. The ... blood-red lump on the head or facethen grow rapidly in ...
... Missouri Botanical Garden in St. Louis operates one of ... and the second largest in the western hemisphere. With ... a gigantic new aroid species from Ecuador, the ... has reached a milestone of six million specimens. ...
Cached Biology News:Providing toilets, safe water is top route to reducing world poverty: UN University 2Providing toilets, safe water is top route to reducing world poverty: UN University 3Providing toilets, safe water is top route to reducing world poverty: UN University 4Providing toilets, safe water is top route to reducing world poverty: UN University 5Researchers identify Achilles heel of common childhood tumor 2Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen 2Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen 3
(Date:1/14/2014)... and BETHESDA, Md. , ... joining together with two institutes from the National Institutes ... tools for bringing safer, more effective treatments to patients ... National Center for Advancing Translational Sciences (NCATS) and the ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation ... developing and commercializing innovative therapies addressing major unmet ... it received the Notice of Allowance from the ... unique self-delivering RNAi compounds (sd-rxRNA®), for the treatment ...
(Date:1/14/2014)... Washington, USA, and Cardiff, UK (PRWEB) January 13, 2014 ... photonics technology development leader with more than 20 years ... society for optics and photonics . Hainsey will serve ... are delighted to have Dr. Hainsey join SPIE as ...
(Date:1/14/2014)... 2014 Independent publisher Bitingduck Press, with ... Canada, has big ideas for 2014 in production and ... are to produce high-quality, low-cost, DRM-free ebooks and to ... , The first major development will be bookstore ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... Genzyme Corp. said on Wednesday it has agreed ... Wisconsin-Madison biotech spinoff, for $600 million in cash. , ,Bone ... more than $2 billion and almost 7,000 employees worldwide, plan ... companies recently reported healthy quarterly profits and revenues. Bone Care ...
... a new copy machine for $57,000. , ,The Z-Corp ... typical office copier: It makes three-dimensional models of small structures ... , ,Using white polymer powder and colored inks, the printer ... a time. Z-Corp is headquartered in Burlington, Massachusetts. , , ...
... can submit executive summaries of their businesses for angel ... May 9. , ,The Wisconsin Angel Network ... investor networks with entrepreneurs based on the investors' market ... a deal-flow pipeline, has been designed to be a ...
Cached Biology Technology:Massachusetts firm to buy UW spinoff Bone Care for $600 million 2Massachusetts firm to buy UW spinoff Bone Care for $600 million 3Start-ups, angels can connect on new state Web site 2Start-ups, angels can connect on new state Web site 3
...
... Multidizer is designed with a variety of ... - all in one unit. Shake, rock, ... operating compartments allow for hybridization and blotting ... , The upper chamber uses a ...
... sleek design loaded with class-leading features, the 1400 Series ... work is safe and consistent every time you use ... 1400 Series reduces power consumption by as much as ... over the life of the cabinet. Multiply this ...
... Concentrator, the SPD series takes the 'Classic' ... twist., The SPD121P SpeedVac comes equipped with ... runs; preventing samples from freezing; and allowing ... end-users preset level., Standard features on the ...
Biology Products: