Navigation Links
Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration
Date:9/4/2008

PROVIDENCE New research from Rhode Island Hospital found that obesity and Type 2 Diabetes Mellitus (T2DM) can contribute to mild neurodegeneration with features common with Alzheimer's disease (AD) the first study to show that obesity can cause neurodegeneration. The study appeared in the Journal of Alzheimer's Disease Volume 15:1 (September 2008) .

In a study on animal models, lead researcher Suzanne de la Monte, MD, MPH, of Rhode Island Hospital, utilized chronic high fat diets to cause a two-fold increase in mean body weight. In these animal models, there was a marginally reduced mean brain weight and a significantly reduced mean brain weight/body weight ratio, providing evidence that obesity with T2DM is sufficient to cause mild global atrophy in the brain.

De la Monte says, "In essence, the brain shrinks and several biochemical and molecular abnormalities found in patients with AD, including brain insulin resistance, develop with chronic obesity and T2DM. However, the extent of the abnormalities in no way matches AD." Researchers note that the neuropathological abnormalities were mild and the associated brain insulin resistance could serve as a co-factor in the development and progression of AD.

Overall, the study found that that the effects of obesity and T2DM can essentially aggravate or contribute to the severity or progression of AD, but cannot be the sole cause of the condition. The findings suggest that strategies to reduce obesity and prevent or control T2DM could modify the clinical course of mild cognitive impairment and AD.

De la Monte also notes, "We don't know yet if these effects of T2DM/obesity are reversible with weight loss. However, we're fairly sure that the abnormalities are related to the T2DM that accompanies obesity and not just increased weight."


'/>"/>

Contact: Nancy Cawley
ncawley@lifespan.org
Lifespan
Source:Eurekalert

Page: 1

Related biology news :

1. Study of islands reveals surprising extinction results
2. Sky islands: metaphor or misnomer?
3. Smithsonian coral biodiversity survey of Panamas Pearl Islands
4. Rare North Island brown kiwi hatches at the Smithsonians National Zoo
5. Rats on islands disrupt ecosystems from land to sea, researchers find
6. First wind turbines on Galapagos Islands will halve diesel imports, reduce risk of future oil spills
7. Island monkeys do not recognize big cat calls
8. Ancient whale fall from Californias Ao Nuevo Island one of youngest, most complete known
9. Ancient whale fall from Californias Año Nuevo Island one of youngest, most complete known
10. Childrens Memorial Hospital of Chicago receives a grant from BioMarin to support adult PKU outreach
11. Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohns disease study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/4/2017)... April 4, 2017   EyeLock LLC , a ... the United States Patent and Trademark Office (USPTO) has ... the linking of an iris image with a face ... represents the company,s 45 th issued patent. ... very timely given the multi-modal biometric capabilities that have ...
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive global ... technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, ...
(Date:10/10/2017)... 2017 SomaGenics announced the receipt of a ... RealSeq®-SC (Single Cell), expected to be the first commercially ... microRNAs) from single cells using NGS methods. The NIH,s ... accelerate development of approaches to analyze the heterogeneity of ... techniques for measuring levels of mRNAs in individual cells ...
(Date:10/9/2017)... ... ... The award-winning American Farmer television series will feature 3 Bar Biologics in an ... on RFD-TV. , With global population estimates nearing ten billion people by 2050, ... a growing nation. At the same time, many of our valuable resources are becoming ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... and applications consulting for microscopy and surface analysis, Nanoscience Instruments is now ... Analytical offers a broad range of contract analysis services for advanced applications. ...
Breaking Biology Technology: