Navigation Links
Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
Date:12/25/2013

The results of the largest international study to date into the genetic basis of rheumatoid arthritis shed light on the biology of the disease and provide evidence that large-scale genetic studies can assist in the identification of new drugs for complex disorders such as rheumatoid arthritis.

The study, conducted by Dr. Robert M. Plenge from the Harvard Medical School and the Broad Institute in the USA and Dr. Yukinori Okada from the RIKEN Center for Integrative Medical Sciences in Japan, collaborating with colleagues from 70 institutions worldwide, is published today in the journal Nature.

Genome-wide association studies are a method employed by scientists to identify the genes contributing to human disease. The current Nature study is the first to demonstrate that integrating the information provided by genome-wide association studies with existing datasets of genomic and biological information, such as drug targets, can assist in the discovery of drugs to cure human disease.

Rheumatoid arthritis is an autoimmune disease leading to inflammation of the joints and affecting 0.5-1% of adults in the developed world. The disease is thought to be caused by a complex combination of genetic and environmental factors and several genes have been shown to be associated with the disease. However, most of the findings were based on single population studies, and no large-scale trans-ethnic study had been carried out to date.

The international team performed a genome-wide association study meta-analysis on a total of over 100,000 subjects of European and Asian descent - 29,880 rheumatoid arthritis patients and 73,758 controls by analysing around 10 million genetic variants called single nucleotide polymorphism (SNPs). They identified 42 new regions in the genome (loci) that are associated with rheumatoid arthritis, bringing the total number of known rheumatoid arthritis loci to 101.

By conducting bioinformatic
'/>"/>

Contact: Juliette Savin
pr@riken.jp
81-048-462-1225
RIKEN
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
2. Study links intestinal bacteria to rheumatoid arthritis
3. Bacteria responsible for gum disease facilitates rheumatoid arthritis
4. Clingy platelets suggest potential treatment strategy for rheumatoid arthritis
5. Novel biomarkers improve diagnosis in rheumatoid arthritis
6. Discovery shows fat triggers rheumatoid arthritis
7. Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
8. Bartonella infection associated with rheumatoid illnesses in humans
9. New target identified for preventing bone destruction in diseases such as arthritis and cancer
10. Osteoarthritis medicine delivered on-demand
11. National Psoriasis Foundation awards 12 psoriasis and psoriatic arthritis research fellowships
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
(Date:10/22/2014)... Oct. 21, 2014 Aware, Inc. (NASDAQ: ... today reported financial results for its third quarter ended September ... 2014 was $6.0 million, an increase of 40% compared to ... in the third quarter of 2014 was $4.1 million compared ... operating income in the current three month period was primarily ...
(Date:10/18/2014)... of patients with undiagnosed, suspected genetic conditions, a certain ... higher molecular diagnostic yield than traditional molecular diagnostic methods, ... The study is being released to coincide with the ... sequencing, which sequences the protein­coding region of the genome ... in a cell or organism), has been rapidly applied ...
(Date:10/17/2014)... German . ... When treating overdoses, doctors are often limited to supportive therapy ... is a combination of drugs involved. So what can be ... grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute of ... to this question. "The task was to develop an agent ...
Breaking Biology News(10 mins):Aware, Inc. Reports Third Quarter 2014 Financial Results 2Aware, Inc. Reports Third Quarter 2014 Financial Results 3Aware, Inc. Reports Third Quarter 2014 Financial Results 4Aware, Inc. Reports Third Quarter 2014 Financial Results 5Aware, Inc. Reports Third Quarter 2014 Financial Results 6Aware, Inc. Reports Third Quarter 2014 Financial Results 7Study examines type of exome sequencing and molecular diagnostic yield 2Study examines type of exome sequencing and molecular diagnostic yield 3Emergency aid for overdoses 2Emergency aid for overdoses 3
... Direction Chocolate Chip Cookies TM lower cholesterol and ... disease, according to a published study in The Journal ... with a combination of psyllium and plant sterols, are ... with cholesterol. , The American Heart Association estimates ...
... than boots, a screen and a bucket, scientists studying a ... biomass in Tampa Bay now say they have found the ... the development of the modern-day human immune system. , The ... system protein that is similar to but much hardier than ...
... everything of importance in biology. The genome rules all of ... that among the diverse forms of RNA, a kind of ... and with genes directly to manage the genome from behind ... the vast stretches of DNA that do not code for ...
Cached Biology News:New study finds chocolate chip cookies lower cholesterol 2Tiny Tampa Bay fish key to evolution of immune system 2Tiny Tampa Bay fish key to evolution of immune system 3Peering into the shadow world of RNA 2Peering into the shadow world of RNA 3
(Date:10/25/2014)... October 24, 2014 SonaCare Medical, ... ultrasound (HIFU) technology, announced that its Board of ... Chief Executive Officer, President and member of the ... Carol will take-on expanded responsibilities within the company, ... well as overseeing commercialization, manufacturing and finance. ...
(Date:10/25/2014)... ROCKVILLE, Md. , Oct. 24, 2014  RegeneRx Biopharmaceuticals, ... on data presented at the Fourth International Symposium on ... , Italy.  "When thymosin beta ... was injected into the peritoneal cavity in a rodent ... vessels and throughout the brain parenchyma (the functional tissue ...
(Date:10/22/2014)... -- Research and Markets has announced ... Market (Product types, Application, Technology, End User and ... Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation and ... offering. This new report titled, ... and Geography) Global Size, Industry Analysis, Trends, Opportunities, ...
(Date:10/22/2014)... Involution Studios , a healthcare software ... infographic, Understanding Ebola . The goal of ... to follow informative tool for anyone wanting to know ... prevention. , "As the news has spread in all ... represents not only a healthcare crisis with global impact, ...
Breaking Biology Technology:SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 2SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 3Researchers Report Thymosin Beta 4 Crosses Blood-Brain Barrier In Animal Stroke Model 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2
... THE WOODLANDS, Texas, September 1 Berlin Heart Inc.,reported ... the Berlin,Heart EXCOR(R) Pediatric IDE Study after having received unconditional,approval ... The Principal Investigator, Dr. Charles Fraser, ... of Surgery and Pediatrics,at Baylor College of Medicine ...
... , , ST. LOUIS and ... MON ) today announced a non-exclusive research and commercial license agreement ... genome engineering, for broad use of its meganuclease technology in plants. ... be directed to a single site in the genome of a ...
... HARBIN, China, Sept. 1 /PRNewswire-Asia-FirstCall/ -- China Kangtai ... integrated grower,developer, manufacturer and marketer of a variety ... company has successfully completed the trial,production of cactus-based ... the,forth quarter in 2009: (i) low nicotine and ...
Cached Biology Technology:Major Milestone Achieved - Berlin Heart EXCOR Pediatric IDE Study 2Monsanto Licenses Use of Cellectis' Innovative Genome Modification Technology 2Monsanto Licenses Use of Cellectis' Innovative Genome Modification Technology 3China Kangtai Cactus Biotech to Launch Patented Cactus-based Low Tar, Low or Zero Nicotine Cigarettes 2China Kangtai Cactus Biotech to Launch Patented Cactus-based Low Tar, Low or Zero Nicotine Cigarettes 3
The Holten Safe 2010 Class II Biological Safety Cabinets provide the most ergonomical working condition of comfort while incorporating the latest technology for safety, efficiency and performance....
... is designed with a variety of motion ... all in one unit. Shake, rock, roll ... compartments allow for hybridization and blotting procedures ... , The upper chamber uses a roller ...
... Magnetic Stand-96 is designed for paramagnetic bead ... 0.2 ml PCR plates with no additional ... base in a standard SBS 96-well microplate ... permanent magnets guarantees easy and fast (as ...
... magnetic particle based purification systems provide high ... any sample. They offer increased throughput and ... systems- KingFisher, KingFisher mL and KingFisher 96, ... l. Each system consists of an instrument, ...
Biology Products: