Navigation Links
Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
Date:12/25/2013

The results of the largest international study to date into the genetic basis of rheumatoid arthritis shed light on the biology of the disease and provide evidence that large-scale genetic studies can assist in the identification of new drugs for complex disorders such as rheumatoid arthritis.

The study, conducted by Dr. Robert M. Plenge from the Harvard Medical School and the Broad Institute in the USA and Dr. Yukinori Okada from the RIKEN Center for Integrative Medical Sciences in Japan, collaborating with colleagues from 70 institutions worldwide, is published today in the journal Nature.

Genome-wide association studies are a method employed by scientists to identify the genes contributing to human disease. The current Nature study is the first to demonstrate that integrating the information provided by genome-wide association studies with existing datasets of genomic and biological information, such as drug targets, can assist in the discovery of drugs to cure human disease.

Rheumatoid arthritis is an autoimmune disease leading to inflammation of the joints and affecting 0.5-1% of adults in the developed world. The disease is thought to be caused by a complex combination of genetic and environmental factors and several genes have been shown to be associated with the disease. However, most of the findings were based on single population studies, and no large-scale trans-ethnic study had been carried out to date.

The international team performed a genome-wide association study meta-analysis on a total of over 100,000 subjects of European and Asian descent - 29,880 rheumatoid arthritis patients and 73,758 controls by analysing around 10 million genetic variants called single nucleotide polymorphism (SNPs). They identified 42 new regions in the genome (loci) that are associated with rheumatoid arthritis, bringing the total number of known rheumatoid arthritis loci to 101.

By conducting bioinformatics studies integrating existing datasets with this new information, the researchers were able to pinpoint 98 genes in these 101 loci that could potentially contribute to the onset of rheumatoid arthritis. By integrating their findings with existing drug databases they demonstrate that these genes indeed possess many overlapping regions with the genes targeted by approved rheumatoid arthritis drugs although this wasn't known when the drugs were developed. The team identify existing drugs used to treat cancer that also target rheumatoid arthritis genes and could potentially be used as therapy for the disease, such as CDK4/6 inhibitors.

The bioinformatics study also reveals that there is significant overlap between the genes involved in rheumatoid arthritis, human primary immunodeficiency disorders and blood cancers.

"This study sheds light on the fundamental genes, pathways and cell types that contribute to the onset of rheumatoid arthritis and provides evidence that the genetics of rheumatoid arthritis can provide important information for drug discovery," conclude the authors.

"While there are previous anecdotal examples, our study provides a systematic approach by which human genetic data can be efficiently integrated with other biological information to derive biological insights and drug discovery," they add.


'/>"/>

Contact: Juliette Savin
pr@riken.jp
81-048-462-1225
RIKEN
Source:Eurekalert  

Related biology news :

1. Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
2. Study links intestinal bacteria to rheumatoid arthritis
3. Bacteria responsible for gum disease facilitates rheumatoid arthritis
4. Clingy platelets suggest potential treatment strategy for rheumatoid arthritis
5. Novel biomarkers improve diagnosis in rheumatoid arthritis
6. Discovery shows fat triggers rheumatoid arthritis
7. Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders
8. Bartonella infection associated with rheumatoid illnesses in humans
9. New target identified for preventing bone destruction in diseases such as arthritis and cancer
10. Osteoarthritis medicine delivered on-demand
11. National Psoriasis Foundation awards 12 psoriasis and psoriatic arthritis research fellowships
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
(Date:3/22/2017)... Calif. , March 21, 2017 ... analytics company serving law enforcement agencies, announced today the ... as director of public safety business development. ... diversified law enforcement experience, including a focus on the ... In his most recent position, Mr. Sheridan served as ...
(Date:3/16/2017)... Germany , March 16, 2017 CeBIT 2017 - Against identity ... Continue Reading ... Used combined in one project, multi-biometric solutions provide ... Used ... Systems) ...
(Date:3/9/2017)... FRANCISCO and MOUNTAIN VIEW, Calif. ... , "Eating Well Made Simple," and 23andMe , ... help guide better food choices.  Zipongo can now provide ... their food preferences, health goals and biometrics, but also ... certain food choices. Zipongo,s personalized food decision ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... April 21, 2017 , ... ... applications were the focus of researchers, engineers, product developers, and industry suppliers gathered ... , Sponsored by SPIE, the international society for optics and photonics , ...
(Date:4/20/2017)... Ca (PRWEB) , ... April 20, 2017 , ... ... Virtual Event , this new webinar will explore challenging patient cases when screening ... to the hospital, there may be a need for bridging parental anticoagulation especially ...
(Date:4/20/2017)... ... April 20, 2017 , ... Husson University will be celebrating ... body of knowledge during its Eighth Annual Research and Scholarship Day ... Atrium. During the event, undergraduates, graduate students, and faculty members from all of ...
(Date:4/20/2017)... San Diego, CA (PRWEB) , ... April 20, 2017 , ... ... and management of clinical trials worldwide, announced today that they were named one of ... magazine , which covers the latest developments in the pharmaceutical industry. , “We take ...
Breaking Biology Technology: