Navigation Links
Rewrite the textbooks: Transcription is bidirectional
Date:1/25/2009

Genes that contain instructions for making proteins make up less than 2% of the human genome. Yet, for unknown reasons, most of our genome is transcribed into RNA. The same is true for many other organisms that are easier to study than humans. Researchers in the groups of Lars Steinmetz at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and Wolfgang Huber at the European Bioinformatics Institute (EMBL-EBI) in Hinxton, UK, have now unravelled how yeast generates its transcripts and have come a step closer to understanding their function. The study, published online in Nature, redefines the concept of promoters (the start sites of transcription) contradicting the established notion that they support transcription in one direction only. The results are also representative of transcription in humans.

Investigating all transcripts produced in a yeast cell, the scientists found that most regions of the yeast genome produce several transcripts starting at the same promoter. These transcripts are interleaved and overlapping on the DNA. In contrast to what was previously thought, the vast majority of promoters seem to initiate transcription in both directions.

Not all of the produced transcripts are stable, many are degraded rapidly making it difficult to observe what they do. While some of the RNA molecules might be 'transcriptional noise' without function, other transcripts control the expression of genes and production of proteins. The act of transcription itself is also likely to play an important role in regulation of gene expression. Transcribing one stretch of DNA might either help or in other cases interfere with the transcription of a gene close by. Moreover, transcripts without a current purpose can serve as 'raw material for evolution' and acquire new functions over time.

The results shed light on the complex organisation of the yeast genome and the insights gained extend to transcription in humans.
'/>"/>

Contact: Anna-Lynn Wegener
wegener@embl.org
49-622-138-7452
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rosella research could rewrite ring theory
2. Smithsonian scientists find evidence that could rewrite Hawaiis botanical history
3. Primitive early relative of armadillos helps rewrite evolutionary family tree
4. CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery
5. Early-stage gene transcription creates access to DNA
6. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
7. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
8. Research sheds light on the mechanics of gene transcription
9. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... on how the bowel lining develops and, in the ... starts. , The researchers produced evidence that stem cells ... are a feature of the bowel lining, and believe ... a controversial finding as scientists are still divided on ... Dr Chin Wee Tan and Professor Tony Burgess from ...
(Date:10/16/2014)... Post-menopausal women experienced improvements in vaginal atrophy, with ... bleeding, after 12 weeks of daily 10 milligram ... nutritional supplement previously shown to help relieve certain ... study reported in a poster at the North ... , "These data documented improved vaginal epithelium, without ...
(Date:10/15/2014)... our ability to assess the pandemic risk from strains ... we must not allow ourselves to become complacent that ... international consortium of scientists. , Influenza pandemics arise when ... yet to develop widespread immunity – spreads in the ... the past 100 years, the worst of which – ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
... at how much you can learn from a plant. In ... a Michigan State University professor and a colleague discuss why if ... to plants for any number of valuable lessons. "Metabolism of ... Last, an MSU professor of biochemistry and molecular biology. "As the ...
... scientists have added to a growing list of types ... the genetic code, they have found the short strands ... from Howard Hughes Medical Institute (HHMI) scientists suggests those ... engine, capable of querying the entire history of a ...
... prefer inexpensive, traditional stoves for cooking over modern ones ... in the Proceedings of the National Academy of ... that indoor smoke from the traditional stoves is harmful, ... spoiled food (66 percent). Still, Bangladeshi women opted for ...
Cached Biology News:Scientists urge new approaches to plant research 2Short stretches of piRNA evaluate cells' genetic history 2Short stretches of piRNA evaluate cells' genetic history 3Bangladeshi women prefer pollution-causing cookstoves 2
(Date:10/19/2014)... October 20, 2014 OCTOBER ... Meeting (ABIM). ABIM will take place ... information about ABIM 2014 is now available ... Delegates representing companies and organizations from all ... obtain information on the latest products and ...
(Date:10/19/2014)... 2014 The Asia-Pacific Bromine Market ... Asia-Pacific with analysis and forecast of revenue. , ... Bromine Market report, to get an idea of ... glimpse of the segmentation in the Asia-Pacific bromine ... figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine ...
(Date:10/19/2014)... 2014 The Asia-Pacific Speech Analytics market ... Asia-Pacific with analysis and forecast of revenue. This market ... to $208 million by 2019, at a Compound Annual ... , Browse through the TOC of the Asia-Pacific Speech ... in-depth analysis provided. It also provides a glimpse of ...
(Date:10/19/2014)... The Asian Orthopedic braces and support systems ... analysis and forecast of revenue. The Orthopedic braces and support ... $416.5 million by 2018, at a developing CAGR of 4.4% ... the Asian Orthopedic braces and support systems market, to get ... a glimpse of the segmentation of orthopedic braces and support ...
Breaking Biology Technology:The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
... Genome Sciences,Inc. (Nasdaq: HGSI ) announced today ... Biotechnology & Medical Device Conference will,be webcast and ... (Logo: http://www.newscom.com/cgi-bin/prnh/20010612/HGSLOGO ), A member ... present,an overview of the company on Wednesday, February ...
... Plant First to be Awarded Shingo Prize Outside of North ... ... Baxter International Inc.,s,(NYSE: BAX ) manufacturing facility in Cartago, Costa Rica ... the first to be awarded the Shingo Prize outside North America,-- is ...
... recent study published this month,in the journal, Pediatrics, suggests ... linked to the presence of phthalates in babies. Phthalates,are ... variety of everyday,products. They are used primarily as plasticizers, ... be used to stabilize and make,fragrances work properly. The ...
Cached Biology Technology:Baxter's Costa Rica Facility Recognized With Shingo Prize for Excellence in Manufacturing 2Statement by John Bailey, Chief Scientist: The Personal Care Products Council Response to Study on Phthalate Exposure in Baby Care Products 2
Hybridization chamblers suitable for use with all ChIP-GLAS microarrays....
Integrins Sampler Kit 10g each...
Protein Tyrosine Phosphatase Sampler Kit 10g each...
... Solid phase reagent for ... Easy & unique water ... with detergents and chaotropes; ... recover non-envelop viruses while ...
Biology Products: