Navigation Links
Rewrite the textbooks: Transcription is bidirectional
Date:1/25/2009

Genes that contain instructions for making proteins make up less than 2% of the human genome. Yet, for unknown reasons, most of our genome is transcribed into RNA. The same is true for many other organisms that are easier to study than humans. Researchers in the groups of Lars Steinmetz at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and Wolfgang Huber at the European Bioinformatics Institute (EMBL-EBI) in Hinxton, UK, have now unravelled how yeast generates its transcripts and have come a step closer to understanding their function. The study, published online in Nature, redefines the concept of promoters (the start sites of transcription) contradicting the established notion that they support transcription in one direction only. The results are also representative of transcription in humans.

Investigating all transcripts produced in a yeast cell, the scientists found that most regions of the yeast genome produce several transcripts starting at the same promoter. These transcripts are interleaved and overlapping on the DNA. In contrast to what was previously thought, the vast majority of promoters seem to initiate transcription in both directions.

Not all of the produced transcripts are stable, many are degraded rapidly making it difficult to observe what they do. While some of the RNA molecules might be 'transcriptional noise' without function, other transcripts control the expression of genes and production of proteins. The act of transcription itself is also likely to play an important role in regulation of gene expression. Transcribing one stretch of DNA might either help or in other cases interfere with the transcription of a gene close by. Moreover, transcripts without a current purpose can serve as 'raw material for evolution' and acquire new functions over time.

The results shed light on the complex organisation of the yeast genome and the insights gained extend to transcription in humans. A better understanding of transcription mechanisms could find application in new technologies to tune gene regulation in the future.


'/>"/>

Contact: Anna-Lynn Wegener
wegener@embl.org
49-622-138-7452
European Molecular Biology Laboratory
Source:Eurekalert

Related biology news :

1. Rosella research could rewrite ring theory
2. Smithsonian scientists find evidence that could rewrite Hawaiis botanical history
3. Primitive early relative of armadillos helps rewrite evolutionary family tree
4. CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery
5. Early-stage gene transcription creates access to DNA
6. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
7. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
8. Research sheds light on the mechanics of gene transcription
9. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
Breaking Biology News(10 mins):
(Date:6/26/2017)... ... June 26, 2017 , ... Third Wave Bioactives, LLC announces the addition ... on leading new business development and ensuring quality customer experience. , Brett ... ingredient industry in technical, marketing and sales roles. “Brett’s background working with customers and ...
(Date:6/23/2017)... , ... June 23, 2017 , ... Ken Hanson, a ... of Physik Instrumente USA, have been selected as this year’s recipients of two top ... two have been invited along with other honorees to accept their awards at a ...
(Date:6/22/2017)... ... June 21, 2017 , ... Building on the success of the inaugural RAADfest ... the very latest developments in radical life extension. RAADfest combines cutting edge science presented ... empowerment of personal development, making it the largest most comprehensive and inclusive super longevity ...
(Date:6/22/2017)... ... ... The first human cell line HeLa, established in 1951, has entered cell ... human cell lines with HeLa cells were published. Until recently, cross-contamination and misidentification of ... associated with dramatic consequences for research. , In this educational webinar, which is ...
Breaking Biology Technology: