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Rewiring of gene regulation across 300 million years of evolution
Date:4/9/2010

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"By studying changes in transcription factor binding, we can understand the evolution of gene regulation," said Duncan Odom from Cancer Research UK Cambridge Research Institute and coauthor on the paper. He continued: "Differences in gene regulation are central to explaining differences between species, and gene misregulation is a key causative factor in diseases like cancer."

The results reveal that sequence conservation is not the whole story when it comes to maintaining tissue-specific gene regulation.


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Contact: Katrina Pavelin
contactpress@ebi.ac.uk
European Molecular Biology Laboratory
Source:Eurekalert

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