Navigation Links
Revolutionary new view on heritability in plants
Date:2/11/2014

Complex heritable traits are not only determined by changes in the DNA sequence. Scientists from the University of Groningen Bioinformatics Centre, together with their French colleagues, have shown that epigenetic marks can affect traits such as flowering time and architecture in plants. Furthermore, these marks are passed on for many generations in a stable manner. Their results were published in Science Express on Thursday, 6 February 2014. It seems that a revision of Genetics textbooks is now in order.

We've all been taught that DNA is the physical foundation of heredity. Our genes are spelled out in the four famous letters A, T, C and G, which together form the genetic code. A single letter change in this code can lead to a gene ceasing to function or failing to work properly.

The fact that the functioning of our genes is also affected by epigenetic marks has been known for decades. For example, the nucleotide cytosine (the C in the genetic code) can be changed into a methylcytosine. This cytosine methylation, which is one type of epigenetic mark, is typically associated with repression of gene activity.

Epigenetic inheritance

'While in mammals epigenetic marks are typically reset every generation, in plants no such dramatic resetting takes place. This opens the door to epigenetic inheritance in plants: epigenetic changes that are acquired in one generation tend to be stably passed on to the next generation', explains Frank Johannes, assistant professor at the GBIC and co-lead scientist for the Science Express study. Johannes's French colleagues have produced inbred strains of the model plant Arabidopsis, in which the epigenetic marks vary between strains although the DNA sequence is almost identical. Nevertheless, these strains show marked differences in appearance, which are passed on to later generations.

Complex traits

In the new study, Johannes and his French colleagues have successfully linked variation in epigenetic markers to complex traits such as flowering time and plant architecture in these Arabidopsis strains. They employed techniques that are typically used by geneticists to locate the DNA regions with sequence variations that contribute to complex traits. These are called quantitative trait loci or QTLs.

Breakthrough

Johannes: 'We used the same method to locate regions in the DNA, not with different sequences but with different epigenetic marks that contribute to certain traits in the plant.' It is the first time that epigenetic differences have been unequivocally shown to contribute to heritable traits. 'This is a breakthrough, because it changes the way we view genetics. And it may even be of huge economic importance.'

Commercially interesting

Although the Science Express paper is based on heritability over just seven generations, other results with the Arabidopsis strains show that epigenetic traits are stably inherited for at least 20 generations. Johannes: 'Such stable traits can be of interest to plant breeders. Apart from variations in the gene sequence, epigenetic variation may contribute to commercially interesting traits.'

Evolution

The epigenetic markers may also affect evolution, independent of DNA sequence. 'They cause variation on which natural selection can act', Johannes explains. As such, traits caused by epigenetic variation may make an independent contribution to changes in a species. 'Our findings were made using inbred strains, but we also have evidence that we can find some of the same epigenetic QTLs in wild populations of this species as well.' This suggests it is not just a laboratory artefact but something that plays a role in nature.

Revision textbooks

Johannes points out that 'because epigenetic inheritance differs between plants and mammals, it is by no means certain that similar processes play a role in mammalian populations like humans.' But the textbooks on plant genetics are now due for revision in any case.


'/>"/>

Contact: Dr. Frank Johannes
f.johannes@rug.nl
31-503-638-079
University of Groningen
Source:Eurekalert

Related biology news :

1. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
2. Sandia seeks commercial partners for revolutionary SpinDx medical diagnostic tool
3. WHOI scientists/engineers partner with companies to market revolutionary new instruments
4. Physicists explore properties of electrons in revolutionary material
5. DARPA director: Revolutionary weapons require strong S&T partnerships
6. Carnegie debuts revolutionary biosphere mapping capability at AGU
7. Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe
8. A revolutionary new 3-D digital brain atlas
9. Not just for the birds: Man-made noise has ripple effects on plants, too
10. Human noise has ripple effects on plants
11. Plants mimic scent of pollinating beetles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... at the Pennsylvania Convention Center and will showcase its product’s latest features from ... also be presenting a scientific poster on Disrupting Clinical Trials in The Cloud ...
(Date:6/23/2016)... -- Amgen (NASDAQ: AMGN ) today announced a ... sciences incubator to accelerate the development of new therapies ... QB3@953 was created to help high-potential life science and ... stage organizations - access to laboratory infrastructure. ... "Amgen Golden Ticket" awards, providing each winner with one ...
(Date:6/22/2016)... , June 22, 2016 Research and ... Global Markets" report to their offering. ... billion in 2014 from $29.3 billion in 2013. The market is ... of 13.8% from 2015 to 2020, increasing from $50.6 billion in ... projected product forecasts during the forecast period (2015 to 2020) are ...
Breaking Biology Technology: