Navigation Links
Reviving a foe of cancer
Date:4/25/2013

nificantly suppressed tumor growth in mice.

"These results demonstrate that functional p53 in melanoma is normally inhibited by two different factors, instead of one, as previously thought. They also provide a proof of principle that both of those factors need to be blocked if p53 is to be successfully reactivated in cancer cells," said Lu.

Since multiple signaling pathways drive the growth of tumor cells, Lu and her colleagues wondered if the restoration of p53 function could be used as a strategy to enhance existing cancer therapies that target parallel signaling pathways. To find out, they treated advanced melanomas with JNJ, Nutlin-3 and a chemotherapeutic drug used in the clinic today named vemurafenib. This drug specifically inhibits BRAFV600E, a mutated protein that drives cancer cell proliferation. With such treatment, advanced melanoma tumors in preclinical mouse models shrank by a full 75 percent after 28 days of treatment. This has notable implications for the treatment of cancers in which p53 is not mutated but is instead functionally silencedroughly half of all cancer cases.

Based on their results, Lu and her colleagues argue that the best strategy in such cases might be to use drug combinations that target multiple, parallel pathways involved in tumor development and maintenance. Such combinations of drugs that normally have short-term efficacy could achieve an additive, if not a long-term synergistic effect.


'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. OHSU teams with Intel to decode the root causes of cancer and other complex diseases
2. Particular DNA changes linked with prostate cancer development and lethality
3. Cold winters freezing out breast cancer treatment
4. Identified as responsible for breast and ovarian hereditary cancer 3 mutations at BRCA1 gene
5. Ben-Gurion U. and Fox Chase Cancer Center awarded NIH measles grant
6. Researchers abuzz over caffeine as cancer-cell killer
7. An important discovery in breast cancer by IRCM researchers
8. UCLA researchers find nanodiamonds could improve effectiveness of breast cancer treatment
9. Icy therapy spot treats cancer in the lung
10. IMPAKT -- Translational research breast cancer conference
11. LSUHSC research discovers new drug target for metastatic breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... On the eve of United Nations General Assembly events ... of mothers, newborns and children, Grand Challenges Canada, funded ... in grants for 22 bold ideas to address this ... A program for Bangladeshi mothers working in garment ... thereby improving infant nutrition, reducing absenteeism due to child ...
(Date:9/21/2014)... strains of bacteria have emerged that resist even the ... forms of tuberculosis and staphylococcus, infect more than 2 ... the urgent need for new treatments, scientists have discovered ... decade. , MIT engineers have now turned a powerful ... that can disable any target gene, they have shown ...
(Date:9/19/2014)... from several Harvard University labs in collaboration with ... researchers with the intellectual raw materials needed to ... flexible materials. , With the advent of low-cost ... manufacturing technology, soft robotics is emerging as an ... rigid robot design, but working with pliable materials, ...
Breaking Biology News(10 mins):Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 2Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 3Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 4Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 5Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 6Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 7Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 8Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 9Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 10Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 11Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 12Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 13Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 14Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 15Battling superbugs 2Battling superbugs 3Battling superbugs 4Soft robotics 'toolkit' features everything a robot-maker needs 2
... one day be synthesised using biotechnology, following CSIRO,s discovery ... beetles with their potent predator defence system., CSIRO researchers, ... of the gene identification breakthrough and potential applications recently ... the first time, our team has been able to ...
... crocodiles and alligators are much prized by the fashion ... animals. Some are from endangered species and according to ... way to distinguish legitimate hides from poached skins is ... pigmented bumps that pepper crocodiles, bodies. Adding that the ...
... following 110,645 workers who helped clean up after the ... Soviet territory of Ukraine shows that the workers share ... may help scientists better define cancer risk associated with ... such as computed tomography scans and other sources. ...
Cached Biology News:Gene find turns soldier beetle defence into biotech opportunity 2Tactile croc jaws more sensitive than human fingertips 2Tactile croc jaws more sensitive than human fingertips 3Chernobyl cleanup workers had significantly increased risk of leukemia 2Chernobyl cleanup workers had significantly increased risk of leukemia 3
(Date:9/22/2014)... have developed a unique nanoscale device that for ... The discovery could have major implications for creating ... and communication. , The research paper by University ... Mo Li and his graduate student Huan Li ... the October issue of Nature Nanotechnology . ...
(Date:9/22/2014)... , Sept. 22, 2014 US demand to ... for specialty biocides is forecast to rise 3.9 percent ... terms, demand is projected to increase 1.3 percent per ... A strong rebound in construction expenditures will support demand ... coatings markets, while growth in consumer spending and manufacturing ...
(Date:9/22/2014)... Research and Markets has announced ... Cellulose Industry Report 2014" report to their offering. ... Industry Report 2014 is a professional and in-depth study ... industry with a focus on the Chinese situation. ... industry including definitions, classifications, applications and industry chain structure. ...
(Date:9/22/2014)... September 22, 2014 FierceBiotech today announced ... held biotechnology companies of 2014. FierceBiotech editors John ... selecting this year’s winners. Those selected are identified ... in the industry. , "It's always a ... of Fierce 15 companies," said Carroll. "This year in ...
Breaking Biology Technology:Engineers show light can play seesaw at the nanoscale 2US Biocides Market 2US Biocides Market 3Global and Chinese Microcrystalline Cellulose Industry Report 2014 2FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2
... Aug. 23 AspenBio Pharma,Inc. (OTC Bulletin Board: APNB) ... drugs and diagnostics for animals and,humans, today announced its ... Markets Stock Exchange has been approved. The company ... the NASDAQ CM commencing with the open of trading ...
... ImmuneRegen,s Homspera(TM) Submitted to RFI, ,Therapeutic ... and B Threat Agents, SCOTTSDALE, Ariz., Aug. ... Inc. a wholly,owned subsidiary of IR BioSciences Holdings, ... has recently responded to a Request for,Information (RFI) ...
... Aug. 22 Biodel, Inc. (Nasdaq:,BIOD) today ... to its,Scientific Advisory Board (SAB). Dr. ... of Research,and Development at Kos Pharmaceuticals, where ... Kos was acquired by Abbott Laboratories. Dr.,Rosskamp,s ...
Cached Biology Technology:AspenBio Pharma Shares to Trade on the NASDAQ Capital Markets Exchange Under Symbol 'APPY' 2AspenBio Pharma Shares to Trade on the NASDAQ Capital Markets Exchange Under Symbol 'APPY' 3AspenBio Pharma Shares to Trade on the NASDAQ Capital Markets Exchange Under Symbol 'APPY' 4ImmuneRegen Responds to Defense Threat Reduction Agency Request for Information 2ImmuneRegen Responds to Defense Threat Reduction Agency Request for Information 3Ralf Rosskamp, M.D. Joins Biodel's Scientific Advisory Board 2Ralf Rosskamp, M.D. Joins Biodel's Scientific Advisory Board 3
MBS 384 well satellite block unit with height adjusting heated lid, 384 well block holds 1 x 0.04 ml 384 well plate...
Wellpro 96 an automated liquid handling system for 96-well plates that quickly and accurately prepares large quantities of serial dilutions. The Wellpro also performs plate to plate transfers using ...
Multidrop DW is a high-speed automated dispenser for Deep Well plates, 1.1 ml test tubes and 96-well plates. Designed for accuracy and precision, the Multidrop DW dispenses up to eight different reag...
...
Biology Products: