Navigation Links
Revisited human-worm relationships shed light on brain evolution
Date:2/9/2011

"Man is but a worm" was the title of a famous caricature of Darwin's ideas in Victorian England. Now, 120 years later, a molecular analysis of mysterious marine creatures unexpectedly reveals our cousins as worms, indeed.

An international team of researchers, including a neuroscientist from the University of Florida, has produced more evidence that people have a close evolutionary connection with tiny, flatworm-like organisms scientifically known as "Acoelomorphs."

The research in the Thursday (Feb. 10) issue of Nature offers insights into brain development and human diseases, possibly shedding light on animal models used to study development of nerve cells and complex neurodegenerative diseases such as Alzheimer's and Parkinson's.

"It was like looking under a rock and finding something unexpected," said Leonid L. Moroz, a professor in the department of neuroscience with the UF College of Medicine. "We've known there were very unusual twists in the evolution of the complex brains, but this suggests the independent evolution of complex brains in our lineage versus invertebrates, for example, in lineages leading to the octopus or the honeybee."

The latest research indicates that of the five animal phyla, the highest classification in our evolutionary neighborhood, four contain worms.

But none are anatomically simpler than "acoels," which have no brains or centralized nervous systems. Less than a few millimeters in size, acoels are little more than tiny bags of cells that breathe through their skin and digest food by surrounding it.

Comparing extensive genome-wide data, mitochondrial genes and tiny signaling nucleic acids called microRNAs, the researchers hailing from six countries determined a strong possibility that acoels and their kin are "sisters" to another peculiar type of marine worm from northern seas, called Xenoturbella.

From there, like playing "Six Degrees of Kevin Bacon," the branches continue to humans.

"If you looked at one of these creatures you would say, 'what is all of this excitement about a worm?'" said Richard G. Northcutt, a professor of neurosciences at Scripps Institution of Oceanography, who was not involved in the study. "These are tiny animals that have almost no anatomy, which presents very little for scientists to compare them with. But through genetics, if the analysis is correct and time will tell if it is the study has taken a very bothersome group that scientists are not sure what to do with and says it is related to vertebrates, ourselves and echinoderms (such as starfish).

"The significance of the research is it gives us a better understanding of how animals are related and, by inference, a better understanding of the history of the animals leading to humans," Northcutt said.

Scientists used high-throughput computational tools to reconstruct deep evolutionary relationships, apparently confirming suspicions that three lineages of marine worms and vertebrates are part of a common evolutionary line called "deuterostomes," which share a common ancestor.

"The early evolution of lineages leading to vertebrates, sea stars and acorn worms is much more complex than most people expect because it involves not just gene gain, but enormous gene loss," said Moroz, who is affiliated with the Whitney Laboratory for Marine Bioscience and UF's McKnight Brain Institute. "An alternative, yet unlikely, scenario would be that our common ancestor had a central nervous system, and then just lost it, still remaining a free living organism.

Understanding the complex cellular rearrangements and the origin of animal innovations, such as the brain, is critically important for understanding human development and disease, Moroz said.

"We need to be able to interpret molecular events in the medical field," he said. "Is what's happening in different lineages of neuronal and stem cells, for example, completely new, or is it reflecting something that is in the arrays of ancestral tool kits preserved over more than 550 million years of our evolutionary history? Working with models of human disease, you really need to be sure."


'/>"/>

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
Source:Eurekalert

Related biology news :

1. 30 years later, what killed the dinosaurs is revisited
2. Students get a feel for soil-water relationships
3. DNA sequencing unlocks relationships among flowering plants
4. Temporary infidelity may contribute to the stability of ancient relationships
5. Relationships in rank and file
6. In child care, relationships with caregivers key to childrens stress levels
7. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
8. AGU journal highlights -- Feb. 9, 2011
9. MedNet Solutions Announces Significant Enhancements to ENLIGHTEN, Its Flagship EDC / eClinical Solution
10. Tall order sunlight-to-hydrogen system works, neutron analysis confirms
11. Oysters at risk: Gastronomes delight disappearing globally
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a ... the MegaMatcher Automated Biometric Identification System (ABIS) ... large-scale multi-biometric projects. MegaMatcher ABIS can process multiple ... using any combination of fingerprint, face or iris ... MegaMatcher SDK and MegaMatcher Accelerator , ...
(Date:4/26/2016)... LONDON , April 26, 2016 /PRNewswire/ ... Systems, a product subsidiary of Infosys (NYSE: ... partnership to integrate the Onegini mobile security platform ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration ... security to access and transact across channels. Using ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... On Wednesday, June 22, 2016, the NASDAQ Composite ... Jones Industrial Average edged 0.27% lower to finish at 17,780.83; ... has initiated coverage on the following equities: Infinity Pharmaceuticals Inc. ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ), ... more about these stocks by accessing their free trade alerts ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... focused on quality, regulatory and technical consulting, provides a free webinar ... presented on July 13, 2016 at 12pm CT at no charge. , Incomplete ...
(Date:6/23/2016)... -- Amgen (NASDAQ: AMGN ) today announced a ... sciences incubator to accelerate the development of new therapies ... QB3@953 was created to help high-potential life science and ... stage organizations - access to laboratory infrastructure. ... "Amgen Golden Ticket" awards, providing each winner with one ...
(Date:6/22/2016)... Cell Applications, Inc. and StemoniX announced ... up to one billion human induced pluripotent stem ... These high-quality, consistent stem cells enable researchers to ... more time doing meaningful, relevant research. This achievement ... process that produces affordable, reliable HiPSC for life ...
Breaking Biology Technology: