Navigation Links
Reversing cognitive deficits: Injectable antibody may attack source of problem
Date:10/8/2007

ST. LOUIS -- A special protein can be injected into the body to reverse learning problems in mice that have an animal version of Alzheimers disease, Saint Louis University researchers have found.

The protein -- part of the immunoglobulin M (IgM) class -- is an antibody that grabs onto the amyloid beta protein in the brain and prevents it from changing into the toxic substance believed to cause Alzheimers disease.

Our research in an animal model showed that antibodies can be developed rationally for treating Alzheimers disease, says William A. Banks, M.D. professor of geriatrics and pharmacological and physiological science at Saint Louis University. Its a major thing that people have been trying to do -- get antibodies into the brain in the right amount to treat illnesses. This antibody does that.

Banks says the findings are surprising because IgM is five times bigger than the antibody immunoglobulin G (IgG), which has already been studied as a potential therapy for Alzheimers disease.

Because it is larger, scientists didnt believe it could cross the blood- brain barrier, a protective membrane that keeps foreign substances out of the brain.

We collaborated with Michael Steinitz from Hebrew University in Jerusalem, who developed an antibody that is part of the IgM class of antibodies that would stick better to amyloid beta protein, says Banks, who also is a staff physician at Veterans Affairs Medical Center in St. Louis Banks says.

This compound had better entry to the brain than IgG, even though they are smaller.

A single intravenous dose of IgM reversed cognitive impairment in aged mice that have a genetic mutation that causes deficits similar to those found in patients with Alzheimers disease, Banks says.

The findings were published in the August issue of Experimental Neurology.


'/>"/>
Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
Source:Eurekalert

Page: 1

Related biology news :

1. Reversing cancer cells to normal cells
2. Reversing hibernating heart muscle focus of UB researchers
3. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
4. Alzheimers cognitive decline slowed
5. Brain networks change according to cognitive task
6. Navigating the brain for sense of direction as paradigm for higher cognitive functions
7. Engineered mouse mimics cognitive aspects of schizophrenia
8. AIDS-related cognitive impairment exists in two separate forms
9. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
10. Master planners in brain may coordinate other areas roles in cognitive tasks
11. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... , January 22, 2016 ... the addition of the  "Global Behavioral ... offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ... "Global Behavioral Biometric Market 2016-2020"  report ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ...
(Date:1/20/2016)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is pleased to announce the attainment of record-setting corporate ... of the company,s laser focus on (and growing international ... comprehensive, easy-to-use and highly affordable cloud-based technology platform. ... growth achievements in 2015 include: , Record ...
(Date:1/13/2016)... New York , January 13, 2016 ... Market Research has published a new market report titled ... Growth, Trends, and Forecast, 2015 - 2023. According to the ... in 2014 and is anticipated to reach US$1,625.8 mn ... 2015 to 2023. In terms of volume, the biometric ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... PA (PRWEB) , ... February 09, 2016 , ... Tunnell ... Europe. Based in Paris, he will focus on acquiring new accounts and work ... met. , “Fred brings to our European clients more than 15 ...
(Date:2/9/2016)... , Feb. 9, 2016  DNAtrix, a ... for cancer, announced that its lead product, ... Commission as an orphan medicinal product for ... form of glioma, strikes approximately 25,000 people ... http://photos.prnewswire.com/prnh/20160208/330986LOGO --> ...
(Date:2/9/2016)... , Feb. 9, 2016 BERG, a ... biological research approach, has announced the appointment of ... and Chief Operating Officer. Haddock brings to BERG ... including 12 years in senior financial functions at ... in business organizational management. Niven ...
(Date:2/8/2016)... , Feb. 8, 2016  CytRx Corporation ... development company specializing in oncology, today announced that ... security agreement with Hercules Technology Growth Capital, Inc. ... $40 million in financing. --> ... first $25 million of financing under the loan ...
Breaking Biology Technology: