Navigation Links
Reversing cognitive deficits: Injectable antibody may attack source of problem

ST. LOUIS -- A special protein can be injected into the body to reverse learning problems in mice that have an animal version of Alzheimers disease, Saint Louis University researchers have found.

The protein -- part of the immunoglobulin M (IgM) class -- is an antibody that grabs onto the amyloid beta protein in the brain and prevents it from changing into the toxic substance believed to cause Alzheimers disease.

Our research in an animal model showed that antibodies can be developed rationally for treating Alzheimers disease, says William A. Banks, M.D. professor of geriatrics and pharmacological and physiological science at Saint Louis University. Its a major thing that people have been trying to do -- get antibodies into the brain in the right amount to treat illnesses. This antibody does that.

Banks says the findings are surprising because IgM is five times bigger than the antibody immunoglobulin G (IgG), which has already been studied as a potential therapy for Alzheimers disease.

Because it is larger, scientists didnt believe it could cross the blood- brain barrier, a protective membrane that keeps foreign substances out of the brain.

We collaborated with Michael Steinitz from Hebrew University in Jerusalem, who developed an antibody that is part of the IgM class of antibodies that would stick better to amyloid beta protein, says Banks, who also is a staff physician at Veterans Affairs Medical Center in St. Louis Banks says.

This compound had better entry to the brain than IgG, even though they are smaller.

A single intravenous dose of IgM reversed cognitive impairment in aged mice that have a genetic mutation that causes deficits similar to those found in patients with Alzheimers disease, Banks says.

The findings were published in the August issue of Experimental Neurology.

Contact: Nancy Solomon
Saint Louis University

Page: 1

Related biology news :

1. Reversing cancer cells to normal cells
2. Reversing hibernating heart muscle focus of UB researchers
3. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
4. Alzheimers cognitive decline slowed
5. Brain networks change according to cognitive task
6. Navigating the brain for sense of direction as paradigm for higher cognitive functions
7. Engineered mouse mimics cognitive aspects of schizophrenia
8. AIDS-related cognitive impairment exists in two separate forms
9. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
10. Master planners in brain may coordinate other areas roles in cognitive tasks
11. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
Post Your Comments:
(Date:11/17/2015)... 2015  Vigilant Solutions announces today that Mr. ... Directors. --> --> ... the partnership at TPG Capital, one of the largest ... Billion in revenue.  He founded and led TPG,s Operating ... companies, from 1997 to 2013.  In his first role, ...
(Date:11/12/2015)... 2015   Growing need for low-cost, easy ... been paving the way for use of biochemical ... analytes in clinical, agricultural, environmental, food and defense ... in medical applications, however, their adoption is increasing ... continuous emphasis on improving product quality and growing ...
(Date:11/9/2015)... SAN JOSE, Calif. , Nov. 9, 2015 /PRNewswire/ ... of human interface solutions, today announced broader entry into ... of vehicle-specific solutions that match the pace of consumer ... drivers, and biometric sensors are ideal for the automotive ... the vehicle. Europe , ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... Report is a professional and in-depth study on ...      (Logo: ) , ... the industry including definitions, classifications, applications and industry ... for the international markets including development trends, competitive ...
(Date:11/24/2015)... Nov. 24, 2015 Halozyme Therapeutics, Inc. (NASDAQ: HALO ... New York on Wednesday, December 2 at ... , president and CEO, will provide a corporate overview. ... at 1:00 p.m. ET/10:00 a.m. PT . ... will provide a corporate overview. --> th Annual ...
(Date:11/24/2015)... , Nov. 24, 2015  Clintrax Global, Inc., a worldwide provider ... , today announced that the company has set a new ... 391% quarter on quarter growth posted for Q3 of 2014 to ... and Mexico , with the establishment of an ... 2015. --> United Kingdom and ...
(Date:11/24/2015)... 2015 --> ... released by Transparency Market Research, the global non-invasive prenatal ... of 17.5% during the period between 2014 and 2022. ... Industry Analysis, Size, Volume, Share, Growth, Trends and Forecast ... market to reach a valuation of US$2.38 bn by ...
Breaking Biology Technology: