Navigation Links
Reversing cognitive deficits: Injectable antibody may attack source of problem
Date:10/8/2007

ST. LOUIS -- A special protein can be injected into the body to reverse learning problems in mice that have an animal version of Alzheimers disease, Saint Louis University researchers have found.

The protein -- part of the immunoglobulin M (IgM) class -- is an antibody that grabs onto the amyloid beta protein in the brain and prevents it from changing into the toxic substance believed to cause Alzheimers disease.

Our research in an animal model showed that antibodies can be developed rationally for treating Alzheimers disease, says William A. Banks, M.D. professor of geriatrics and pharmacological and physiological science at Saint Louis University. Its a major thing that people have been trying to do -- get antibodies into the brain in the right amount to treat illnesses. This antibody does that.

Banks says the findings are surprising because IgM is five times bigger than the antibody immunoglobulin G (IgG), which has already been studied as a potential therapy for Alzheimers disease.

Because it is larger, scientists didnt believe it could cross the blood- brain barrier, a protective membrane that keeps foreign substances out of the brain.

We collaborated with Michael Steinitz from Hebrew University in Jerusalem, who developed an antibody that is part of the IgM class of antibodies that would stick better to amyloid beta protein, says Banks, who also is a staff physician at Veterans Affairs Medical Center in St. Louis Banks says.

This compound had better entry to the brain than IgG, even though they are smaller.

A single intravenous dose of IgM reversed cognitive impairment in aged mice that have a genetic mutation that causes deficits similar to those found in patients with Alzheimers disease, Banks says.

The findings were published in the August issue of Experimental Neurology.


'/>"/>
Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
Source:Eurekalert

Page: 1

Related biology news :

1. Reversing cancer cells to normal cells
2. Reversing hibernating heart muscle focus of UB researchers
3. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
4. Alzheimers cognitive decline slowed
5. Brain networks change according to cognitive task
6. Navigating the brain for sense of direction as paradigm for higher cognitive functions
7. Engineered mouse mimics cognitive aspects of schizophrenia
8. AIDS-related cognitive impairment exists in two separate forms
9. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
10. Master planners in brain may coordinate other areas roles in cognitive tasks
11. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
(Date:4/26/2016)... Research and Markets has announced ... 2016-2020"  report to their offering.  , ,     (Logo: ... analysts forecast the global multimodal biometrics market to ... period 2016-2020.  Multimodal biometrics is being ... the healthcare, BFSI, transportation, automotive, and government for ...
(Date:4/15/2016)... , April 15, 2016 ... "Global Gait Biometrics Market 2016-2020,"  report to their ... ) , ,The global gait biometrics market ... 13.98% during the period 2016-2020. Gait ... which can be used to compute factors that ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
(Date:6/23/2016)... SANTA MONICA, Calif. , June 23, 2016  The Prostate Cancer ... to pioneer increasingly precise treatments and faster cures for prostate cancer. Members of ... 77 institutions across 15 countries. Read More About the ... ... ...
(Date:6/23/2016)... NC (PRWEB) , ... June 23, 2016 , ... In ... University Hospital in Denmark detail how a patient who developed lymphedema after being treated ... tissue. The results could change the paradigm for dealing with this debilitating, frequent side ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the ... Convention Center and will showcase its product’s latest features from June 26 to ... a scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
Breaking Biology Technology: