Navigation Links
Reversing cognitive deficits: Injectable antibody may attack source of problem
Date:10/8/2007

ST. LOUIS -- A special protein can be injected into the body to reverse learning problems in mice that have an animal version of Alzheimers disease, Saint Louis University researchers have found.

The protein -- part of the immunoglobulin M (IgM) class -- is an antibody that grabs onto the amyloid beta protein in the brain and prevents it from changing into the toxic substance believed to cause Alzheimers disease.

Our research in an animal model showed that antibodies can be developed rationally for treating Alzheimers disease, says William A. Banks, M.D. professor of geriatrics and pharmacological and physiological science at Saint Louis University. Its a major thing that people have been trying to do -- get antibodies into the brain in the right amount to treat illnesses. This antibody does that.

Banks says the findings are surprising because IgM is five times bigger than the antibody immunoglobulin G (IgG), which has already been studied as a potential therapy for Alzheimers disease.

Because it is larger, scientists didnt believe it could cross the blood- brain barrier, a protective membrane that keeps foreign substances out of the brain.

We collaborated with Michael Steinitz from Hebrew University in Jerusalem, who developed an antibody that is part of the IgM class of antibodies that would stick better to amyloid beta protein, says Banks, who also is a staff physician at Veterans Affairs Medical Center in St. Louis Banks says.

This compound had better entry to the brain than IgG, even though they are smaller.

A single intravenous dose of IgM reversed cognitive impairment in aged mice that have a genetic mutation that causes deficits similar to those found in patients with Alzheimers disease, Banks says.

The findings were published in the August issue of Experimental Neurology.


'/>"/>
Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
Source:Eurekalert

Page: 1

Related biology news :

1. Reversing cancer cells to normal cells
2. Reversing hibernating heart muscle focus of UB researchers
3. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
4. Alzheimers cognitive decline slowed
5. Brain networks change according to cognitive task
6. Navigating the brain for sense of direction as paradigm for higher cognitive functions
7. Engineered mouse mimics cognitive aspects of schizophrenia
8. AIDS-related cognitive impairment exists in two separate forms
9. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
10. Master planners in brain may coordinate other areas roles in cognitive tasks
11. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)... , Dec. 2, 2014   Marvin ... deployed, innovative test solutions for military, aerospace, and ... version of its successful TS-900 PXI semiconductor ... and features of high-end systems to customers at ... value compared to traditional ATE. ...
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
(Date:11/21/2014)... VIEW, Calif. , Nov. 20, 2014 ... higher driver efficiency are piloting the North American and ... number of accidents growing, gesture recognition systems that are ... make a mark in the industry. ... the Automotive Gesture Recognition Market in Europe ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... Ministry of Education and Research (BMBF) will fund the ... II) by German and international researchers to the tune ... The Helmholtz Research Centers Juelich, Berlin, and Geesthacht are ... The basis for these grants is the cooperation between ...
... 2010 Scientists from the Florida campus of The ... infectious protein that can cause fatal neurodegenerative disease such ... have the ability to adapt to survive in a ... lack DNA and RNA, they behave much like viruses, ...
... beetroot juice suggests it,s not only athletes who can benefit ... help the elderly or people with heart or lung-conditions enjoy ... the biggest stories in sports science over the past year ... people to exercise for up to 16% longer. The startling ...
Cached Biology News:German federal government bolsters neutron research in Garching 2German federal government bolsters neutron research in Garching 3Scripps Research scientists show prions mutate and adapt to host environment 2Scripps Research scientists show prions mutate and adapt to host environment 3Beetroot juice could help people live more active lives 2
(Date:12/17/2014)... December 17, 2014 Xeno Diagnostics ... following its most recent COLA inspection. Xeno has ... a national healthcare accreditation organization. Accreditation is earned ... quality in day-to-day operations, demonstrate continued accuracy in ... rigorous on-site laboratory survey. , While ...
(Date:12/17/2014)... Audacity, a leading California-based health and ... the Huntsworth Health Group, is proud to announce the ... her role, Gonzales will serve as Senior Vice President ... to welcome a talent of Jamie’s caliber to the ... “She is a proven healthcare innovation leader and brand ...
(Date:12/17/2014)... 17, 2014  United Therapeutics Corporation (NASDAQ: ... well as changes to Martine Rothblatt , Ph.D,s ... United Therapeutics announced the promotion of ... Officer and David Zaccardelli , Pharm.D. to Executive ... these promotions, Dr. Rothblatt,s title will change from Chairman ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4
... September 27, 2011 Circassia Ltd, ... announced positive phase II clinical results showing that ... allergy symptoms compared with those on placebo.  The ... During the randomised, double-blind, placebo-controlled phase II study ...
... Researchers of the Chemical Engineering department and the Kavli ... have demonstrated that electrons can move freely in layers ... This new knowledge will be very useful for the ... The researchers published their findings on Sunday 25 September ...
... ( www.ucr.edu ) -- Two professors from the University ... $1.5 million to study a new approach that could ... and increase speed in the next generation of computers. ... chair of the materials science and engineering program, and ...
Cached Biology Technology:Circassia's Hay Fever Treatment Improves Patients' Allergy Symptoms in Phase II Clinical Trial 2Circassia's Hay Fever Treatment Improves Patients' Allergy Symptoms in Phase II Clinical Trial 3TU Delft: cheap and efficient solar cell made possible by linked nanoparticles 2Bold approach could change electronics industry 2Bold approach could change electronics industry 3
... Reduce bench time to just 15 minutes! ... the paralles that can be drawn between this ... idea of instant foods. Instant meals consumed ... freeze-dried format and are reconstituted by adding water. ...
APO(a) EIA Sample Size: 25 l...
...
Request Info...
Biology Products: