Navigation Links
Reversing cognitive deficits: Injectable antibody may attack source of problem
Date:10/8/2007

ST. LOUIS -- A special protein can be injected into the body to reverse learning problems in mice that have an animal version of Alzheimers disease, Saint Louis University researchers have found.

The protein -- part of the immunoglobulin M (IgM) class -- is an antibody that grabs onto the amyloid beta protein in the brain and prevents it from changing into the toxic substance believed to cause Alzheimers disease.

Our research in an animal model showed that antibodies can be developed rationally for treating Alzheimers disease, says William A. Banks, M.D. professor of geriatrics and pharmacological and physiological science at Saint Louis University. Its a major thing that people have been trying to do -- get antibodies into the brain in the right amount to treat illnesses. This antibody does that.

Banks says the findings are surprising because IgM is five times bigger than the antibody immunoglobulin G (IgG), which has already been studied as a potential therapy for Alzheimers disease.

Because it is larger, scientists didnt believe it could cross the blood- brain barrier, a protective membrane that keeps foreign substances out of the brain.

We collaborated with Michael Steinitz from Hebrew University in Jerusalem, who developed an antibody that is part of the IgM class of antibodies that would stick better to amyloid beta protein, says Banks, who also is a staff physician at Veterans Affairs Medical Center in St. Louis Banks says.

This compound had better entry to the brain than IgG, even though they are smaller.

A single intravenous dose of IgM reversed cognitive impairment in aged mice that have a genetic mutation that causes deficits similar to those found in patients with Alzheimers disease, Banks says.

The findings were published in the August issue of Experimental Neurology.


'/>"/>
Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
Source:Eurekalert

Page: 1

Related biology news :

1. Reversing cancer cells to normal cells
2. Reversing hibernating heart muscle focus of UB researchers
3. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
4. Alzheimers cognitive decline slowed
5. Brain networks change according to cognitive task
6. Navigating the brain for sense of direction as paradigm for higher cognitive functions
7. Engineered mouse mimics cognitive aspects of schizophrenia
8. AIDS-related cognitive impairment exists in two separate forms
9. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
10. Master planners in brain may coordinate other areas roles in cognitive tasks
11. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... , April 15, 2016 ... "Global Gait Biometrics Market 2016-2020,"  report to their ... ) , ,The global gait biometrics market ... 13.98% during the period 2016-2020. Gait ... which can be used to compute factors that ...
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
(Date:3/22/2016)... and SANDY, Utah , ... which operates the highest sample volume laboratory in ... Genomics and UNIConnect, leaders in clinical sequencing informatics and ... launch of a project to establish the informatics infrastructure ... NSO has been contracted by the Ontario ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... developed by Medistem Panama Inc. at the City of Knowledge in ... tissue-derived mesenchymal stem cells in the US earlier this year following FDA approval ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... cuvettes are used in leading laboratories all over the globe. Their cute firefly ... addition to manufacturing awesome cuvettes, FireflySci makes spectrophotometer calibration standards that never require ...
(Date:5/25/2016)... ... May 25, 2016 , ... Thailand’s Board of ... 2016 in San Francisco. Located at booth number 7301, representatives from the Thai ... and discuss the Thai biotechnology and life sciences sector. , Deputy Secretary ...
(Date:5/25/2016)... ... May 25, 2016 , ... Founder of the Fitzmaurice ... surgery and surgery of the hand by the National Board of Physicians and ... above and beyond in his pursuit of providing the most comprehensive, effective treatment ...
Breaking Biology Technology: