Navigation Links
Reversing Alzheimer's gene 'blockade' can restore memory, other cognitive functions
Date:2/29/2012

CAMBRIDGE, Mass. -- MIT neuroscientists have shown that an enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers were able to reverse Alzheimer's symptoms.

The finding suggests that drugs targeting the enzyme, known as HDAC2, could be a promising new approach to treating the disease, which affects 5.4 million Americans. The number of Alzheimer's victims worldwide is expected to double every 20 years, and President Barack Obama recently set a target date of 2025 to find an effective treatment.

Li-Huei Tsai, leader of the research team, says that HDAC2 inhibitors could help achieve that goal, though it would likely take at least 10 years to develop and test such drugs.

"I would really strongly advocate for an active program to develop agents that can contain HDAC2 activity," says Tsai, director of the Picower Institute for Learning and Memory at MIT. "The disease is so devastating and affects so many people, so I would encourage more people to think about this."

Tsai and her colleagues report the findings in the Feb. 29 online edition of Nature. Lead author of the paper is Johannes Grff, a postdoc at the Picower Institute.

Genome modification

Histone deacetylases (HDACs) are a family of 11 enzymes that control gene regulation by modifying histones proteins around which DNA is spooled, forming a structure called chromatin. When HDACs alter a histone through a process called deacetylation, chromatin becomes more tightly packaged, making genes in that region less likely to be expressed.

HDAC inhibitors can reverse this effect, opening up the DNA and allowing it to be transcribed.

In previous studies, Tsai had shown that HDAC2 is a key regulator of learning and memory. In the new study, her team discovered that inhibiting HDAC2 can reverse A
'/>"/>

Contact: David Vaughn, Picower
dmvaughn@mit.edu
617-452-3342
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Hopes for reversing age-associated effects in MS patients
2. Reversing aging
3. New breathing therapy reduces panic and anxiety by reversing hyperventilation
4. Study reveals new possibility of reversing damage caused by MS
5. Preventing or reversing inflammation after heart attack, stroke may require 2-pronged approach
6. Reversing ecology reveals ancient environments
7. Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development
8. Restored wetlands rarely equal condition of original wetlands
9. Using air pollution thresholds to protect and restore ecosystem health
10. New composite material may restore damaged soft tissue
11. Stem cells restore cognitive abilities impaired by brain cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... great diversity in their ability to identify scents and ... in their perceptual evaluation of odors, with women outperforming ... , Sex differences in olfactory detection may play a ... to one,s perception of smell, which is naturally linked ... has been suggested to be cognitive or emotional, rather ...
(Date:11/4/2014)... Think about the way our bodies are assembled during ... that they are supposed to become a nerve or ... the correct place and alignment? Researchers at the University ... In a new study, UM researchers describe the signaling ... neighbors, at the head-trunk region. Their discovery may have ...
(Date:11/4/2014)... 2014   Neurotechnology , a provider of ... latest version of its fingerprint matching algorithm has ... evaluation organized by NIST. The MINEX test ... INCITS 378 fingerprint standard template format. MINEX compliance ... in the United States ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2The inside story: How the brain and skull stay together 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
... As thousands of pink-footed geese (Anser brachyrhynchus) prepare ... in the Arctic, ecologists are warning that the ... threatening the birds' survival. Writing in the new ... Applied Ecology, Professor Marcel Klaassen of the Netherlands ...
... Hospital of Pittsburgh have found that increased levels of ... signal brain injury in infants with vomiting, fussiness and ... baby syndrome (SBS) ?the most common cause of severe ... because doctors rarely receive a history that an infant ...
... artificial sweeteners such as saccharin with a sensory ... sweet taste has guided researchers to an increased ... , Reporting in an advance online publication ... Center describe how certain artificial sweeteners, including sodium ...
Cached Biology News:Spring migration of pink-footed geese under threat 2Pittsburgh researchers discover that certain chemicals in the blood may indicate brain injury 2Sweet 'water taste' paradoxically predicts sweet taste inhibitors 2
(Date:11/18/2014)... 18, 2014 Alanda Software, a ... Reporting solutions, announced today that a top tier ... Consummate Provider™ solution in both the U.S. and ... SaaS based, Data Quality remediation portal, designed to ... party Providers improve their ability to capture, transmit ...
(Date:11/18/2014)... Array Architects is proud of a ... the nation's hospitals and health systems. It is a ... their careers to the advancement of both the healthcare ... respective field, Laura Silvoy has been chosen to share ... Simulation Conference. , Laura will present her Process ...
(Date:11/18/2014)...  Novira Therapeutics, Inc., a privately held biopharmaceutical company ... B virus (HBV) infection, today announced that Brian ... Advisory Board (SAB).  "We are thrilled ... S. Schade , Chief Executive Officer of Novira.  "Brian ... be invaluable to Novira as our lead core inhibitor ...
(Date:11/16/2014)... (PRWEB) November 16, 2014 James Hill ... With Filtered Fume Hoods, 3 Years Later” scheduled for ... fall of 2011, Butler University surprised many in the ... in their organic chemistry and general chemistry teaching laboratories ... due to building age and substantial growth within the ...
Breaking Biology Technology:Alanda Software Completes Successful Implementation of Global Data Quality & Vendor Management Solution for Top Tier Global Biopharmaceutical Company 2Array Healthcare Simulation Expert Slated to Speak at Winter Simulation Conference 2Novira Therapeutics Announces Appointment of Brian F. Daniels, M.D., to its Scientific Advisory Board 2Novira Therapeutics Announces Appointment of Brian F. Daniels, M.D., to its Scientific Advisory Board 3Don't miss the I2SL High-Tech Talks Webinar Series Presenting: Butler University's Renovation With Filtered Fume Hoods, 3 Years Later 2Don't miss the I2SL High-Tech Talks Webinar Series Presenting: Butler University's Renovation With Filtered Fume Hoods, 3 Years Later 3
... , ... SmithKline Beecham Pharmaceuticals, UK , ... FlashPlate is a 96-well white polystyrene microplate with scintillant-coated wells designed ... as a platform for the measurement of G-protein activation by means of ...
... L. Smith1, M.J. Price-Jones 1 , K.T. Hughes 1 ... Whitchurch, Cardiff, CF4 7YT, Wales, UK, 2 PerkinElmer Life Sciences, P.O.Box ... , INTRODUCTION , ... designed for liquid scintillation (LS) or luminescence detection of samples in microtitration plates, ...
... , Thomas Wampler , ... Limestone Road , Oxford, PA 19363-0277 , ... The use of analytical pyrolysis 1 with gas chromatography/ mass spectrometry (GC/MS) ... these large molecules behave at elevated temperatures. The utility of the technique is based on ...
Cached Biology Technology:Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor 2Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor 3Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor 4Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor 5Counting Cytostar-T scintillating microplates on the MicroBeta JET 2Counting Cytostar-T scintillating microplates on the MicroBeta JET 3Counting Cytostar-T scintillating microplates on the MicroBeta JET 4Counting Cytostar-T scintillating microplates on the MicroBeta JET 5Polymer Degradation Mechanisms Encountered in Pyrolysis-GC/MS 2Polymer Degradation Mechanisms Encountered in Pyrolysis-GC/MS 3Polymer Degradation Mechanisms Encountered in Pyrolysis-GC/MS 4
... cap mat made from an inert polymer with ... 384 split septum caps for use ... Suitable for PCR when used in conjunction with ... Pierceable with standard pipetting equipment 384 septum ...
... Buffer is a unique alternative to ... (TRIS acetate-EDTA) electrophoresis buffers. Bionic Buffer ... rapid running times, and high-resolution band ... gel electrophoresis after dilution to working ...
The Mu-End™ Protein Truncation Kit provides a convenient method for generating a library of N-terminal and C-terminal protein deletions that can be expressed in E. coli....
... Mouse Cytokine Array is a multiplex sandwich ... measurement of 12 cytokines in serum; EDTA, ... Each well of the microplate provided is ... in standards and samples added to the ...
Biology Products: