Navigation Links
Reversible 3-D cell culture gel invented
Date:9/28/2008

Singapore's Institute of Bioengineering and Nanotechnology (IBN), which celebrates its fifth anniversary this year, has invented a unique user-friendly gel that can liquefy on demand, with the potential to revolutionize three-dimensional (3D) cell culture for medical research.

As reported in Nature Nanotechnology (Y.S. Pek, A. C. A. Wan, A. Shekaran, L. Zhuo and J. Y. Ying, "A Thixotropic Nanocomposite Gel for Three-Dimensional Cell Culture"), IBN's novel gel media has the unique ability to liquefy when it is subjected to a moderate shear force and rapidly resolidifies into a gel within one minute upon removal of the force. This phenomenon of reverting between a gel and a liquid state is known as thixotropy.

IBN's thixotropic gel is synthesized from a nanocomposite of silica and polyethylene glycol (PEG) under room temperature, without special storage conditions. This novel material facilitates the safe and convenient culture of cells in 3D since cells can be easily added to the gel matrix without any chemical processes.

According to IBN Executive Director Jackie Y. Ying, Ph.D., "Cell culture is conventionally performed on a flat surface such as glass slides. It is an essential process in biological and medical research, and is widely used to process cells, synthesize biologics and develop treatments for a large variety of diseases.

"Cell culture within a 3D matrix would better mimic the actual conditions in the body as compared to the conventional 2D cell culture on flat surfaces. 3D cell culture also promises the development of better cell assays for drug screening," Dr. Ying added.

Another key feature of IBN's gel is the ease with which researchers can transfer the cultured cells from the matrix by pipetting the required amount from the liquefied gel.

Unlike conventional cell culture, trypsin is not required to detach the cultured cells from the solid media. As trypsin is an enzyme that is kno
'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2

Related biology news :

1. Meeting the challenges of teaching agriculture
2. Plants in forest emit aspirin chemical to deal with stress; discovery may help agriculture
3. Study: Migrant laborers valuable to horticulture industry
4. New study points to agriculture in frog sexual abnormalities
5. Ancient sunflower fuels debate about agriculture in the Americas
6. Aquaculture concept leaves judges goggle eyed
7. Tomato pathogen genome may offer clues about bacterial evolution at dawn of agriculture
8. Stevens researchers provide oversight for three-year mariculture program in Egypt and Israel
9. Agriculture is changing the chemistry of the Mississippi River
10. MIT: Culture influences brain function
11. Agriculture experts meet in Beijing to examine impacts of food prices and climate change on farmers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... Scientists have discovered a new species of mayfly in the ... of India. In fact, this is the first time that ... been collected in peninsular India. , The new species, called ... T. Soldan for his substantial contribution to the understanding of ... authors of a study that describes the new mayfly in ...
(Date:7/27/2014)... "big data," a single computer cannot always find the ... distributed across a cluster of computers that analyze a ... mine your web history to present you with targeted ... favorite book or movie. But big data is about ... monitoring brain activity are generating unprecedented quantities of information. ...
(Date:7/25/2014)... burn scars on this false-color image from the Terra satellite ... year,s rash of wildfires in Eastern Russia. The burn ... green background. The wildfires have broken across the remote ... in this false-color image from the MODIS instrument, it ... fires that continue. Two recent image features noted below show ...
Breaking Biology News(10 mins):New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5
... by Dr. Ann F. Jacobson, associate professor in Kent ... may initially choose to postpone but ultimately undergo total ... patient education before and after the procedure. ... pre-and post operative experiences with total knee replacement surgery, ...
... release is available in Spanish . , A ... (USA) and Nakai (China), among others, have deciphered for the first ... to the cover of the last issue of the prestigious journal ... to the group of Molecular Genetics of the Department of ...
... fund four faculty research projects for spring 2008. ... a number of excellent proposals submitted in response ... for the program is administered by the OSU ... by royalties from OSU-licensed technologies. These funded projects ...
Cached Biology News:Research examines factors in delaying or declining total knee replacement surgery 2Scientists decipher fruit tree genome for the first time 2Scientists decipher fruit tree genome for the first time 3OSU technologies funded for development 2OSU technologies funded for development 3
(Date:7/24/2014)... OAK RIDGE, Tenn., July 24, 2014 -- A novel ... at the Department of Energy,s Oak Ridge National Laboratory ... known for its unusual physical and electrochemical properties. ... examined how oxygen affects the surface of a perovskite ... electronic behavior. The new avenue to understand surface behavior ...
(Date:7/24/2014)... sophisticated equipment, trained personnel, and detection dogs to ... attacks. A revolutionary new electronic chip with nano-sized ... much easier. , The groundbreaking nanotechnology-inspired sensor, devised ... ,s School of Chemistry and Center for Nanoscience ... Tracense, picks up the scent of explosives molecules ...
(Date:7/24/2014)... 2014 Research and Markets has ... Market 2014-2018" report to their offering.  ... is the in vitro growth of plant or animal ... and biopharmaceutical production. Cell culture is a crucial step ... and cell culture consumables are necessary for the in ...
(Date:7/24/2014)... Three companies from the angelMD network were ... Competition. Out of 700 competition entrants, Chiron Health, Litesprite, ... round. In this round twenty teams are invited to ... mentoring from thought-leaders and medical entrepreneurs from all over ... commitment to the Livestrong vision around the Big C ...
Breaking Biology Technology:ORNL study reveals new characteristics of complex oxide surfaces 2Nano-sized chip 'sniffs out' explosives far better than trained dogs 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... Wisconsin's U.S. Senate campaign, Republican Tim Michels ... little more than an inconsequential sideshow. Michels said he ... uses adult stem cells or cells from umbilical cordsbut ... cells. , ,Technology is going to move us away ...
... Madison, Wis. Wisconsin could lose its carefully established ... Midwest if more money is not channeled into academic and ... Download the report (5.4 MB PDF) This ... advisor to the governor on technological matters. The report, titled ...
... businesses TeraMedica scans new market opportunity: smaller hospitals ... Platypus plans office move next June Ink ... more mobile computing Schneider buys GPS to track ... , UW-Extension gets $95,000 to help small businesses ...
Cached Biology Technology:It's 99 percent certain: Research cannot rely on adult stem cells alone 2It's 99 percent certain: Research cannot rely on adult stem cells alone 3Economic report raises red flags on Wisconsin's future 2Economic report raises red flags on Wisconsin's future 3Tech Digest: whats moving in the Midwest 2Tech Digest: whats moving in the Midwest 3
... NaCl, 20mM MOPS, pH 7.5, 60mM ... EGTA, 10 Properites: For selective in ... chromatography, divalent cation activation plus trypsin ... Assurance: routinely evaluated by dephosphorylation of ...
Mouse monoclonal [6G11] to Cytohesin 1 + 2 ( Abpromise for all tested applications)....
HNF-1 Purified Anti-Mouse, Anti-Rat, Anti-Rabbit, Anti-Human clone 2, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Recombinant Porcine IL-1 alpha/IL-1F1, CF...
Biology Products: