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Resveratrol prevents fat accumulation in livers of 'alcoholic' mice
Date:10/14/2008

into groups and fed all of them a low-fat diet. Some mice had resveratrol in their diet, some had resveratrol plus ethanol (alcohol), some had ethanol alone and some had neither ethanol nor resveratrol. The researchers used two different dose levels of resveratrol. At the end of the experiment, they examined the livers of the mice.

The researchers found, as they had expected, that resveratrol treatment increased the expression of SIRT1 and stimulated the activity of AMPK in the livers of mice fed alcohol. They further found that the increased expression of SIRT1 and AMPK led to:

  • Reduction of sterol regulatory element binding protein (SREBP-1)
  • Activation of peroxisome proliferator-activated receptor gamma co-activator alpha (PGC-1α)
  • Elevation of circulating adiponectin, a hormone produced by fat cells, which helps control obesity
  • Enhanced expression of adiponectin receptors in the liver, which increases the effectiveness of the circulating adiponectin.

The findings suggest that resveratrol prevents alcoholic fatty liver by coordinating molecules that control fat metabolism. This prevents accumulation of fat in the mouse liver by both reducing the production of fat and burning off the fat that is there. Interestingly, the combination of alcohol with resveratrol appears to enhance the positive effects of resveratrol, said Dr. You, the study's senior author.

"Our study suggests that resveratrol may serve as a promising agent for preventing or treating human alcoholic fatty liver disease," the authors concluded.


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Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
Source:Eurekalert

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