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Resveratrol, found in red wine, worsens MS-like symptoms and neuropathology in mice
Date:9/30/2013

ase compared with mice fed a control diet, whereas mice treated with resveratrol during the entire treatment period had significantly higher pathology scores in meningitis and overall pathology than controls. Groups did not differ in brain pathology scores.

Although it has been suggested that resveratrol has anti-inflammatory properties, in this study resveratrol did not suppress autoimmune responses as measured by levels of MOG35-55-specific lymphoproliferative responses and pro-inflammatory cytokine production.

To see whether resveratrol had anti-viral properties, as has been reported, 5-week-old mice were infected intracerebrally with the Daniels (DA) strain of Theiler's murine encephalomyelitis virus (TMEV) to induce TMEV-induced demyelinating disease (TMEV-IDD). The mice were fed either a control diet or one containing resveratrol from days 35 to 48 (the chronic phase). Similar to the findings from the EAE model, mice treated with resveratrol developed significantly more severe TMEV-IDD compared with the controls. Another study using the GDVII strain of TMEV to see whether resveratrol could suppress neurodegeneration caused by direct viral infection, not by immunopathology, found that resveratrol had no neuroprotective activity against the virus.

"Resveratrol did not show anti-viral effects in TMEV infection," says Dr. Tsunoda, although he notes that resveratrol has been shown by others to have anti-viral effects on some viruses related to MS, such as herpes simplex virus and Epstein-Barr virus.

To explain their findings, the authors suggest that resveratrol's vasodilating effects via endothelial cells might enhance infiltration of inflammatory cells into the central nervous system, which in turn might play a key role in the pathogenesis of MS.

The degree to which resveratrol exacerbated demyelination and inflammation surprised the research team. "Our findings illustrate that caution should be exercised for poten
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Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

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