Navigation Links
Resveratrol, found in red wine, worsens MS-like symptoms and neuropathology in mice
Date:9/30/2013

Philadelphia, PA, October 1, 2013 -- Resveratrol, a naturally occurring polyphenol compound produced by the skin of red grapes and peanuts, and found in red wine, has been touted as a beneficial supplement due to its anti-inflammatory and antioxidant properties. This has been supported by some experimental studies, whereas others suggest a lack of benefit. A new study using two multiple sclerosis (MS) models published in The American Journal of Pathology has found that resveratrol actually worsened MS-like neuropathology and inflammation and had no neuroprotective effects.

"Resveratrol may have detrimental effects in some disease conditions and should be discouraged for supplemental use by MS patients pending further research," says lead investigator Ikuo Tsunoda, MD, PhD, Assistant Professor in the Department of Microbiology and Immunology, Center for Molecular & Tumor Virology of the Louisiana State University Health Sciences Center, Shreveport, LA.

Investigators (Fumitaka Sato, PhD, et al) tested resveratrol in autoimmune and viral models of MS. In the autoimmune model, experimental autoimmune encephalomyelitis (EAE) was induced in 6-week-old mice using myelin oligodendrocyte glycoprotein (MOG)35-55 peptide. Mice were fed either a control diet or a diet containing resveratrol for 2 months or only during the early (days -1 to 8) or the late (days 14 to 23) phases of EAE. Around 12 days after MOG sensitization, all groups started to develop clinical signs, such as tail and hind limb paralysis, and the symptoms worsened and peaked by 3 weeks. After 5 weeks, mice fed the control diet showed either complete recovery or mild paralysis, but all three groups fed resveratrol exhibited severe and lasting EAE without remission.

Spinal cord neuropathology showed higher pathology scores in demyelination, meningitis, perivascular cuffing (inflammation), and overall pathology in mice that had been given resveratrol during the early ph
'/>"/>

Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Prostate Cancer Foundation announces new urine test for prostate cancer available
2. New York Genome Center announces the New York Stem Cell Foundation as an Associate Member
3. MicroRNA molecule found to be a potent tumor-suppressor in lung cancer
4. Entomological Foundation announces 2013 Insect Science Award winners
5. Life found in the sediments of an Antarctic subglacial lake for the first time
6. Young adults with autism found to have difficulty transitioning into employment
7. Google, Intel founders support undersea research by UMass Amherst microbiologist
8. New patterns found in the genetic relationship of 5 major psychiatric disorders
9. International Rett Syndrome Foundation chief science officer receives prestigious military awards
10. $20,000 APS Foundation grant helps fund TGen2School education initiative
11. New species of Hero Shrew found in equatorial Africa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2015)... 20, 2015  Acuity Market Intelligence,s latest research ... of Commerce and Privacy" forecasts that between 2014 ... will be downloaded to smart mobile devices by ... market is projected to generate more than $67.9 ... seven-year forecast period.    "Biometrics is ...
(Date:7/9/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), a leading ... will report financial results for the fourth quarter and ... the close of market. The company will host a ... p.m. PT (5:00 p.m. ET), during which management may ... the live call, analysts and investors should dial 888-455-2260 ...
(Date:7/9/2015)... JOSE, Calif. , July 9, 2015 ... the leading developer of human interface solutions, ... technology, the industry,s first fully hardware encapsulated ... Match-in-Sensor secure authentication technology is literally off ... storage and biometric matching within the fingerprint ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... biology, molecules can have multi-way interactions within cells, ... has been "incomplete," according to T. M. Murali, ... of Engineering at Virginia Tech. His group ... address these shortcomings, titled "Reverse Engineering Molecular Hypergraphs," ...
... (Boston) According to a new study from the Slone ... sexual or physical abuse before age 11 had a greater ... had no such abuse history. The association was strongest for ... published online in the American Journal of Obstetrics and ...
... University of Pittsburgh School of Medicine may have found ... findings published online today in Chemistry and Biology ... stop the virus from replicating, potentially thwarting HIV infection ... that a small HIV protein called Nef interacts with ...
Cached Biology News:Virginia Tech computer scientists develop new way to study molecular networks 2Abuse during childhood linked to uterine fibroids in African-American women 2Pitt team finds 'Achilles Heel' of key HIV replication protein 2
(Date:7/27/2015)... , July 27, 2015  Amgen (NASDAQ: ... second quarter financial results on Thursday, July 30, 2015, ... announcement will be followed by a conference call with ... the call from Amgen will be Robert A. ... members of Amgen,s senior management team. Live ...
(Date:7/27/2015)... ... July 27, 2015 , ... This is ... report provides a basic overview of the industry including definitions, classifications, applications and ... including development trends, competitive landscape analysis, and key regions development status. Development policies ...
(Date:7/27/2015)... --  Inocucor Technologies Inc ., the agriculture biotech ... has received a notice of allowance from the ... application to protect Inocucor consortia and unique microbial ... on farms and in greenhouses. This ... consortium and its fermentation byproducts, which are the ...
(Date:7/27/2015)... -- According to the new Market Research Report ... by Application (Biobanking, Regenerative Medicine, Drug Discovery), by Geography ( ... Asia-Pacific , Rest of the World) - ... was valued at $247.7 million in 2014, which is estimated ... CAGR of 18.2% between 2014 and 2019. Browse ...
Breaking Biology Technology:Amgen Announces Webcast of 2015 Second Quarter Financial Results 22015 Biophotonics Market Global Research 22015 Biophotonics Market Global Research 3Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 2Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 3Global Biopreservation Media Market to be Worth $571.5 Million by 2019 2Global Biopreservation Media Market to be Worth $571.5 Million by 2019 3
... DCToday, the Wilson Centers Project on Emerging Nanotechnologies, ... magazine and Consumer Reports Online announces a major ... and engage them in an important online conversation ... and consumer products. , This exciting online ...
... With the help of a device capable of depositing ... used in computer chips, a team of University of ... nanomachines. , The work, reported this week (Sept. 26) ... of a new class of nanomechanical devices with implications ...
... $29 Million Expansion of Israel Manufacturing Site, ... a member of the,Sigma-Aldrich(TM) Group (Nasdaq: ... to significantly expand its drug substance capabilities ... Jerusalem, Israel.,The site enhancement will enable SAFC ...
Cached Biology Technology:Project on Emerging Nanotechnologies and Consumers Union collaborate on 'ConsumersTalkNano' 2Doping technique brings nanomechanical devices into the semiconductor world 2SAFC to Expand High-Potency API Fermentation Capabilities 2SAFC to Expand High-Potency API Fermentation Capabilities 3