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Results triple researchers' projections with use of adult stem cells for heart failure
Date:11/14/2011

ORLANDO, Fla. Patients suffering from heart failure due to a previous myocardial infarction showed an average of 12 percent improvement one year following an investigative treatment that involved infusing them with their own stem cells. The results triple the 4 percent improvement average the researchers projected for the Phase I trial.

Results of the trial are published today (Nov. 14) in The Lancet and concurrently presented at the American Heart Association Scientific Sessions in Orlando, Fla. They are the first report of administering subjects' own cardiac stem cells in humans; previous studies have used stem cells harvested from bone marrow.

The research team, led by Dr. Roberto Bolli of the University of Louisville and Dr. Piero Anversa at Brigham and Women's Hospital/Harvard Medical School in Boston, conducted the trial, called "SCIPIO" an acronym for "Cardiac Stem Cells in Patients with Ischemic CardiOmyopathy."

The 16 SCIPIO patients were diagnosed with heart failure following a myocardial infarction and had a left ventricular ejection fraction (LVEF) of 40 percent or lower. LVEF is a standard measure of the heart's pumping capability; it measures how much blood is ejected from the left ventricle during a heartbeat. The normal LVEF is 50 percent or higher.

The investigators harvested cardiac stem cells, referred to as "c-kit positive" cells because they express the c-kit protein on their surface, from the patients during coronary artery bypass surgery conducted at Jewish Hospital in Louisville. The stem cells were purified in Anversa's lab in Boston and allowed to grow. Once an adequate number of stem cells were produced about one million Bolli's team in Louisville reintroduced them into the region of the patient's heart that had been scarred by the infarction.

In designing the trial, Bolli and Anversa examined data from previous studies of bone marrow-derived stem cells and projected an ave
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Contact: Jill Scoggins
jill.scoggins@louisville.edu
502-475-2428
University of Louisville
Source:Eurekalert  

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Results triple researchers' projections with use of adult stem cells for heart failure
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