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Results from trials of DHA in Alzheimer's disease and age-related cognitive decline
Date:7/11/2009

king DHA supplements made significantly fewer errors on the PAL compared to when they started the study (-1.63 0.76, p< 0.03). Plasma phospholipid DHA levels doubled over the course of the study in those people taking the supplements, and correlated with the PAL response (p< 0.04).

They also observed a significant decrease in heart rate in those taking DHA (change from baseline of -3.2 vs. -1 BPM, p< 0.03) that was highly correlated with week 24 plasma levels (p< 0.01). Blood pressure and body weight remained unchanged between groups. Plasma levels of Alzheimer's related proteins Abeta 1-40, 1-42 and hs-CRP were not significantly different.

The researchers observed no treatment-related serious adverse effects in the study, and the adverse effects profile for DHA was the same as for the placebo.

"In our study, healthy people with memory complaints who took algal DHA capsules for six months had almost double the reduction in errors on a test that measures learning and memory performance versus those who took a placebo," Yurko-Mauro said. "The benefit is roughly equivalent to having the learning and memory skills of someone three years younger."


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Contact: Niles Frantz
niles.frantz@alz.org
312-363-8782
Alzheimer's Association
Source:Eurekalert

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