Navigation Links
Response to immune protein determines pathology of multiple sclerosis
Date:10/13/2008

New research may help reveal why different parts of the brain can come under attack in patients with multiple sclerosis (MS). According to a new study in mice with an MS-like disease, the brain's response to a protein produced by invading T cells dictates whether it's the spinal cord or cerebellum that comes under fire. The studyfrom researchers at the University of Maryland School of Medicine in Baltimore and Washington University in St. Louiswill be published online on October 13th in the Journal of Experimental Medicine.

In most MS patients, the disease primarily affects the spinal cord and the white matter of the brain. But a small percentage of patients develop an atypical form of the disease, which primarily affects the cerebellumthe part of the brain that controls sensory perception and movement. For these patients, the disease tends to progress more rapidly and the prognosis is particularly bleak.

MS ensues when the body's T cells invade the brain and trigger nerve-damaging inflammation, in part by secreting proteins called cytokines. According to the new study, lead by Washington University scientist John Russell, the brain's response to one particular immune protein, called interferon-g (IFNg), determines which part of the brain the T cells attack. In mice that are oblivious to IFNg (because they lack its receptor), mice suffer cerebellum and brain stem inflammation, but their spinal cords are spared. When IFNg receptors were left intact, the reverse occurred.

Exactly how the brain's response to IFNg directs the T cell attack is not yet known, but the authors suspect that IFNg triggers a localized production of T cell-attracting proteins in the spinal cord. Translating the details of the "conversation" between T cells and brain cells, suggests Russell, might bring scientists closer to understanding the variable manifestations of human MS.


'/>"/>

Contact: Amy Maxmen
amaxmen@rockefeller.edu
212-327-8393
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Key to out-of-control immune response in lung injury found
2. Flies can turn off their immune response
3. Auto immune response creates barrier to fertility; could be a step in speciation
4. Doctors learn to control their own brains pain responses to better treat patients
5. UVA researchers explain cell response to skin-damaging UV rays
6. Agent that triggers immune response in plants is uncovered
7. Israeli scientists identify: Genes that affect responses of multiple sclerosis patients to copaxone
8. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
9. Triage study challenges notions of emergency medical response to disaster
10. Cell response to stress signals predicts tumors in women with common pre-breast cancer
11. The precise role of seminal proteins in sustaining post-mating responses in fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... July 7, 2015  Based on its recent ... Sullivan recognizes Credence ID, LLC with the 2015 ... of the Year Award. Credence ID has developed ... its mission of offering enrollment and identification solutions ... Credence ID was formed by experts from the ...
(Date:7/2/2015)... -- Fingerprint Cards has received an order for ... the distributor World Peace Industrial Group (WPI), part of WPG ... Asia . Deliveries are planned to take place during ... smartphone manufacturers in Asia . The order ... guidance of approximately 2,200 MSEK for 2015. Jörgen ...
(Date:6/26/2015)... 2015 ATL Technology, LLC, a top provider of ... single use solutions, headquartered in Springville, Utah ... California corporation with locations in ... Costa Rica ). This acquisition will incorporate ... with ATL Technology,s existing facility in Costa Rica ...
Breaking Biology News(10 mins):Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2
... could inspire the next generation of DVD and CD players, ... published today in Nature Photonics . The mantis ... Reef in Australia and have the most complex vision systems ... (humans see in only three) and can distinguish between different ...
... geneticist Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL), ... increases risk for schizophrenia. The mutation in question ... are areas of the genome where the number of copies ... a region referred to by scientists as 16p11.2. By studying ...
... Boston, Mass. -- Researchers at Children,s Hospital Boston report that ... is essential for regenerating damaged axons (nerve fibers) in a ... systems. Their findings, published online by Nature Neuroscience ... it as a possible means of treating stroke, spinal ...
Cached Biology News:Mantis shrimps could show us the way to a better DVD 2CSHL-led team discovers rare mutation dramatically increasing schizophrenia risk 2Master regulator found for regenerating nerve fibers in live animals 2
(Date:7/30/2015)... TX, USA (PRWEB) , ... July 30, 2015 ... ... and microsystems, has appointed Francois Vieillard as Sales & Marketing Director. , ... positions, Francois Vieillard will be responsible for reinforcing Tronics’ business development activities worldwide. ...
(Date:7/30/2015)... , Inc. (NASDAQ: SNMX ), a leading company ... commercialize novel flavor ingredients for the food, beverage, and ... second quarter 2015. "Moving into the ... achieve our commercial and financial goals," stated John Poyhonen, ... our last quarterly earnings report, our two partners have ...
(Date:7/30/2015)... ... 2015 , ... As part of its 2015 growth plan and as a follow up to ... business units, Whitehouse Laboratories is pleased to announce that it has begun construction on a ... Excellence and will be strictly dedicated to basic USP 51, USP 61, and USP 62 ...
(Date:7/29/2015)... 2015 US-Australian drug discovery company, Novogen Limited ... is committed to progressing its ground-breaking technology platforms to ... to ensure the Company delivers the best value for ... Ross , said the Company currently had an extensive ... discovery programs and academic partnerships and initiatives, and he ...
Breaking Biology Technology:Tronics appoints Francois Vieillard as Sales and Marketing Director 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10
... - Rich media developer Sonic Foundry, Inc. ... that has enabled it to access what CEO Rimas Buinevicius ... this process in motion with a registered direct filing ... that seeks to establish a three-year timeframe in which the ...
... Most school districts still are not teaching skills needed for ... are behind in understanding that we are way beyond the ... teaching the classical three Rs. I am not talking about ... and routine. All of these add up to regimentation, which ...
... - Global Renewable LLC, a Whitewater, Wis. partnership that includes ... build and operate a $195 million ethanol plant in the ... approvals, the Sharon Ethanol Plant annually would produce between 105 ... estimated 55 new full-time jobs and more than 200 temporary ...
Cached Biology Technology:Sonic Foundry explores capital options 2Rote education fails the Information Age 2Rote education fails the Information Age 3Rote education fails the Information Age 4