Navigation Links
Resistance gene found against Ug99 wheat stem rust pathogen
Date:6/28/2013

MANHATTAN, Kan. -- The world's food supply got a little more plentiful thanks to a scientific breakthrough.

Eduard Akhunov, associate professor of plant pathology at Kansas State University, and his colleague, Jorge Dubcovsky from the University of California-Davis, led a research project that identified a gene that gives wheat plants resistance to one of the most deadly races of the wheat stem rust pathogen -- called Ug99 -- that was first discovered in Uganda in 1999. The discovery may help scientists develop new wheat varieties and strategies that protect the world's food crops against the wheat stem rust pathogen that is spreading from Africa to the breadbaskets of Asia and can cause significant crop losses.

Other Kansas State University researchers include Harold Trick, professor of plant pathology; Andres Salcedo, doctoral candidate in genetics; and Cyrille Saintenac, a postdoctoral research associate currently working at the Institut National de la Recherche Agronomique in France. The project was funded by the U.S. Department of Agriculture and Borlaug Global Rust Initiative.

The team's study, "Identification of Wheat Gene Sr35 that Confers Resistance to Ug99 Stem Rust Race Group," appears in the journal Science.

It identifies the stem rust resistance gene named Sr35, and appears alongside a study from an Australian group that identifies another effective resistance gene called Sr33.

"This gene, Sr35, functions as a key component of plants' immune system," Akhunov said. "It recognizes the invading pathogen and triggers a response in the plant to fight the disease."

Wheat stem rust is caused by a fungal pathogen. According to Akhunov, since the 1950s wheat breeders have been able to develop wheat varieties that are largely resistant to this pathogen. However, the emergence of strain Ug99 in Uganda in 1999 devastated crops and has spread to Kenya, Ethiopia, Sudan and Yemen, though has yet to reach the U.S.

"Until that point, wheat breeders had two or three genes that were so efficient against stem rust for decades that this disease wasn't the biggest concern," Akhunov said. "However, the discovery of the Ug99 race of pathogen showed that changes in the virulence of existing pathogen races can become a huge problem."

As a first line of defense, wheat breeders and researchers began looking for resistance genes among those that had already been discovered in the existing germplasm repositories, he said.

"The Sr35 gene was one of those genes that was discovered in einkorn wheat grown in Turkey," Akhunov said. "Until now, however, we did not know what kind of gene confers resistance to Ug99 in this wheat accession."

To identify the resistance gene Sr35, the team turned to einkorn wheat that is known to be resistant to the Ug99 fungal strain. Einkorn wheat has limited economic value and is cultivated in small areas of the Mediterranean region. It has been replaced by higher yielding pasta and bread wheat varieties.

Researchers spent nearly four years trying to identify the location of the Sr35 gene in the wheat genome, which contains nearly two times more genetic information than the human genome.

Once the researchers narrowed the list of candidate genes, they used two complimentary approaches to find the Sr35 gene. First, they chemically mutagenized the resistant accession of wheat to identify plants that become susceptible to the stem rust pathogen.

"It was a matter of knocking out each candidate gene until we found the one that made a plant susceptible," Akhunov said. "It was a tedious process and took a lot of time, but it was worth the effort."

Next, researchers isolated the candidate gene and used biotechnical approaches to develop transgenic plants that carried the Sr35 gene and showed resistance to the Ug99 race of stem rust.

Now that the resistance gene has been found, Akhunov and colleagues are looking at what proteins are transferred by the fungus into the wheat plants and recognized by the protein encoded by the Sr35 gene. This will help researchers to better understand the molecular mechanisms behind infection and develop new approaches for controlling this devastating pathogen.


'/>"/>

Contact: Eduard Akhunov
eakhunov@k-state.edu
785-532-1342
Kansas State University
Source:Eurekalert

Related biology news :

1. Antibiotics: Change route of delivery to mitigate resistance
2. An article in Cell reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
3. New agent inhibits HCV replication in mouse models -- No resistance seen
4. Resistance to last-line antibiotic makes bacteria resistant to immune system
5. Biosensor that detects antibiotic resistance brings us one step closer to fighting superbugs
6. Study confirms everolimus can overcome trastuzumab resistance in HER-2 positive early breast cancer
7. Cheers to better beer and disease resistance
8. New study identifies unique mechanisms of antibiotic resistance
9. Study: Widespread test-and-treat HIV policies could increase dangerous drug resistance
10. American Academy of Microbiology releases resistance report
11. COMBACTE: A new step in the fight against resistance to antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2, 2016 The Department of Transport ... the 44 million US Dollar project, for the , ... including Personalization, Enrolment, and IT Infrastructure , to ... production and implementation of Identity Management Solutions. Numerous renowned international ... Decatur was selected for the most compliant ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... for financial services, but it also plays a fundamental part ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former ... of the University of North Carolina Kenan-Flagler Business School effective June ... UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes and ...
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
Breaking Biology Technology: