Navigation Links
Residual dipolar couplings unveil structure of small molecules
Date:2/17/2011

This release is available in German.

The team of Professor Burkhard Luy from KIT and Junior Professor Stefan F. Kirsch from the TUM has now shown for the first time that certain NMR parameters, the so-called residual dipolar couplings (RDCs), can make a significant contribution towards determining the constitution of chemical compounds when traditional methods fail. To do this they embedded molecules of the compound in a gel which slightly constricts their mobility. By stretching the gel, the molecules can be aligned along a preferred orientation. While residual dipolar couplings average out in solution, they become measurable in such partially aligned samples and provide valuable structural information that can be used to build a model of the molecule.

To test this new approach to chemical structure determination the scientists examined a molecule whose atomic composition was known, but not the precise connectivities of the individual atoms in the molecule. The molecule was obtained using a unique reaction, so there were no precedents for its structure. Classical methods of analysis failed because of the compactness of the molecule. In this particular case it was only possible to determine the structure by means of residual dipolar couplings, so that the newly acquired knowledge could be used to draw conclusions about the formation of the molecule something that in the past could only be speculated about.

"This type of analysis will not be suitable for all structures in the future," said scientists Luy and Kirsch. "There will still be molecules whose structures will defy all attempts at unraveling, in spite of tremendous efforts and cutting-edge technologies. But this new method provides us with one further tool to help us unravel the structural mysteries of nature."


'/>"/>

Contact: Dr. Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen
Source:Eurekalert

Page: 1

Related biology news :

1. Online Publishers Association Unveils Biometric and Eye Tracking Research to Assess the Effectiveness of New OPA Ad Units
2. Marine scientists unveil the mystery of life on undersea mountains
3. UCSF unveils model for implantable artificial kidney to replace dialysis
4. UBC researchers unveil toolbox of MiniPromoters for gene research and therapy
5. NPL unveils quantitative means of monitoring ultrasonic cleaning systems
6. BIO-key® to Unveil Enterprise Ready Biometric Identity Platform for Smartphones at the Burton Group Catalyst Conference
7. Mechanism for link between high fat diet and risk of prostate cancer and disorders unveiled
8. McMaster study unveils lifeline for antibiotic of last resort
9. Policy unveiled to combat diarrheal disease, a killer of Kenyan children
10. Results of ecosystem restoration research at Tahoe to be unveiled
11. GestureTek Unveils The CUBE V3 Portable, Plug and Play Interactive Projection Display System for Advertising and Exhibits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... 2017 The research team of The Hong ... fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery and ... speed and accuracy for use in identification, crime investigation, immigration control, ... ... A research team led ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
(Date:3/24/2017)... 2017 Research and Markets has announced the ... & Trends - Industry Forecast to 2025" report to their ... The Global ... CAGR of around 15.1% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
(Date:10/9/2017)... ... October 09, 2017 , ... The ... medical marijuana products targeting the needs of consumers who are incorporating medical marijuana ... place in Phoenix, Arizona. , As operators of two successful Valley dispensaries, The ...
(Date:10/6/2017)... Boston, Mass. (PRWEB) , ... October 06, 2017 ... ... spotlight female entrepreneurship within the healthcare and technology sector at their fourth annual ... six panels featuring 30 inspiring speakers and the ELEVATE pitch competition showcasing early ...
Breaking Biology Technology: