Navigation Links
Researchers work on vaccine to improve immune system in newborns
Date:12/15/2009

COLUMBIA, Mo. As soon as babies are born, they are susceptible to diseases and infections, such as jaundice and e-coli. For up to a month, their immune systems aren't adequately developed to fight diseases. Although these infections are often minor, they can lead to serious problems if left untreated. To help strengthen newborns' immune systems, University of Missouri researchers have pinpointed a group of depleted white blood cells, which might lead to an immune-strengthening vaccine.

"We're trying to improve the immune system of newborns to make them more like adults' immune systems and, therefore, less susceptible to diseases," said Christine Hoeman, doctoral student in the MU School of Medicine. "Although our testing has only been on animal models thus far, our ultimate goal is to create better pediatric vaccines for humans to improve the balance within the immune system."

Hoeman and Habib Zaghouani, professor of molecular microbiology and immunology and child health at the MU School of Medicine, have found that newborns have an imbalance of two different groups of T-helper cells (TH cells), which are white blood cells and the main fighters in the immune system. Newborns have a large amount of TH2 cells, a group of white blood cells that mediate allergic reactions, but not enough of TH1 cells, a group of white blood cells that fight infections.

Environmental factors also affect the imbalance of these two groups of T-helper cells. The first time newborns are exposed to an antigen, or a foreign substance that illicits a response in the immune system, their white blood cells are balanced, but the second time they are exposed to the antigen, they create too much of TH2 and not enough of TH1. This imbalance is what leads to possible infection and allergic reactions.

"What's happening is that the TH2 cells are killing the TH1 cells, creating the imbalance," Hoeman said. "Once we know more about the timeline of the imbalance, we can start to develop the vaccine, which would increase the levels of TH1 and would ideally be administered in newborns soon after they're born."


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and technical consulting, provides a free webinar on Performing Quality Investigations: ... 2016 at 12pm CT at no charge. , Incomplete investigations are still a ...
Breaking Biology Technology: