Navigation Links
Researchers use virus to reveal nanopore physics
Date:6/16/2014

of the variation in translocation speed, it didn't explain it all. Much to the researchers' surprise, they found another source of variation that increased when the voltage across the pore was increased.

"We thought that the physics would be crystal clear," said Jay Tang, associate professor of physics and engineering at Brown and one of the study's co-authors. "You have this stiff [virus] with well-defined diameter and size and you would expect a very clear-cut signal. As it turns out, we found some puzzling physics we can only partially explain ourselves."

The researchers can't say for sure what's causing the variation they observed, but they have a few ideas.

"It's been predicted that depending on where [an object] is inside the pore, it might be pulled harder or weaker," McMullen said. "If it's in the center of the pore, it pulls a little bit weaker than if it's right on the edge. That's been predicted, but never experimentally verified. This could be evidence of that happening, but we're still doing follow up work."

Toward a nanopore sequencer and more

A better understanding of translocation speed could improve the accuracy of nanopore sequencing, McMullen says. It would also be helpful in the crucial task of measuring the length of DNA strands. "If you can predict the translocation speed," McMullen said, "then you can easily get the length of the DNA from how long its translocation was."

The research also helped to reveal other aspects of the translocation process that could be useful in designing future devices. The study showed that the electrical current tends to align the viruses head first to the pore, but on occasions when they're not lined up, they tend to bounce around on the edge of the pore until thermal motion aligns them to go through. However, when the voltage was turned too high, the thermal effects were suppressed and the virus became stuck to the membrane. That suggests a sweet spot i
'/>"/>

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Researchers identify regulation process of protein linked to bipolar disorder
2. Researchers develop free online database for soybean studies
3. NYU and UCSF researchers develop a framework for monitoring oral cancer
4. LSTM researchers identify the complex mechanisms controlling changes in snake venom
5. CU researchers explain mechanism that helps viruses spread
6. UNC researchers pinpoint new role for enzyme in DNA repair, kidney cancer
7. EcoHealth 2014 connects researchers addressing impacts of global change on health and ecosystems
8. Iowa State, Ames Lab researchers find the mechanism that forms cell-to-cell catch bonds
9. Race could be a factor in head and neck cancer survival rates, MU researchers find
10. Researchers shut down a SARS cloaking system; findings could lead to SARS, MERS vaccines
11. Palmer amaranth threatens Midwest farm economy, researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Nov. 20, 2014   Atmel® Corporation (NASDAQ: ... (MCU) and touch technology solutions, today launched the industry,s ... with the widest V cc range from 1.7V ... and faster I 2 C bus communication speeds, and ... memory making them ideal for consumer, industrial, computer, and ...
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... by Yale biologists, of the effects of 1997 El ... the Galpagos Islands, emphasizes the importance of studying populations ... and biological factors make specific populations more vulnerable than ... events provide an ideal system to study the impact ...
... describes hundreds of well-known and respected physicians, scientists, ... or advocated for homeopathic medicine. Eleven U.S. ... Charles Kettering, and C. Everett Koop are among ... benefited from homeopathy. Perhaps most surprisingly is the ...
... CHAMPAIGN, Ill. Using computer simulations, researchers at the University ... driving the molecule back and forth through a nanopore capacitor ... device that would read human genomes quickly and affordably., Being ... (which is the price most insurance companies are willing to ...
Cached Biology News:Global climate change: The impact of El Nio on Galpagos marine iguanas 2The surprising story of Charles Darwin and his homeopathic doctor 2The surprising story of Charles Darwin and his homeopathic doctor 3New technique could dramatically lower costs of DNA sequencing 2
(Date:11/26/2014)... 2014 The North America Thermal ... market for detailed analysis of the growth trends ... reach $616.3 million by 2018, growing at a ... Browse through the TOC of the North America ... idea of the in-depth analysis and industry segmentation ...
(Date:11/26/2014)... , Nov. 26, 2014 The announced ... indicate the company is looking to expand in non-healthcare ... sales.  The healthcare market research firm says that  Siemens ... Kalorama Information,s biennial survey of the IVD market , ... any change in its composition would likely affect IVD ...
(Date:11/26/2014)... The Alliance for Safe Biologic ... European physicians at the "1 ST EuropaBio ... at the Spanish Ministry of Health, Social Services ... the Spanish Bioindustry Association (ASEBIO), included regulators from ... oncology and rheumatology societies, representatives from a hospital ...
(Date:11/26/2014)... November 26, 2014 The ETC ... award-winning technology innovation centers, announced today that applications ... on December 1st. “Do you have a big ... I want to know about it. AccelerateBaltimore helps ... to product in just 13 weeks.” Interested ...
Breaking Biology Technology:The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2ASBM Presents European Physicians Survey at Spanish Ministry of Health 2AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3
... Centers,of America, Inc. (Navitas), the market leader in ... to announce the,appointment of Dean H. Gesme, Jr., ... to currently providing care as a medical oncologist ... as the Past-Chair of the,National Coalition for Cancer ...
... Oct. 17 Monsanto Company (NYSE:,MON) today announced ... president and chief executive officer, and Robb Fraley, ... stock trading,plans in accordance with Rule 10b5-1 of ... plans, the Monsanto executives have directed brokers in ...
... Calif. and OSAKA, Japan, Oct. 17 Affymax,Inc. ... Limited (TSE: 4502),today announced that they have been ... Licensing Executives Society of the U.S. and Canada ... commercialize,Affymax,s lead product candidate, Hematide(TM), for the treatment ...
Cached Biology Technology:Navitas Names Dr. Dean Gesme as Medical Director 2Affymax(R) and Takeda Recognized for Innovative Global Agreement to Develop and Commercialize Hematide(TM) for Anemia 2Affymax(R) and Takeda Recognized for Innovative Global Agreement to Develop and Commercialize Hematide(TM) for Anemia 3
... Invitrogens EvoQuest Services are ... prevail in the current competitive ... proprietary techniques to express, purify, ... your needs: Structure/Function Studies, Activity ...
... Standard Tray (3 per pack), 1. ... and blot processing.Automated staining of Coomassie ... and nucleic acid analysis.Prepares blots for ... detection.Programmable control of protocol, solution, volume, ...
... High quality kits and reagents ... give consistent and reliable 2-D ... up samples from contaminants.Efficiently dialyze ... protein for first-dimension isoelectric focusing.Reagents ...
IMAGEQUANT 300 WKSTN, 1 EA. Category: ImageQuant CCD Imagers....
Biology Products: