Navigation Links
Researchers use neutrons to spy on the elusive hydronium ion
Date:8/8/2011

LOS ALAMOS, New Mexico, August 8, 2011A Los Alamos National Laboratory research team has harnessed neutrons to view for the first time the critical role that an elusive molecule plays in certain biological reactions. The effort could aid in treatment of peptic ulcers or acid reflux disease, or allow for more efficient conversion of woody waste into transportation fuels.

In a paper appearing this week in Angewandte Chemie International Edition, Los Alamos researchers join an international team in describing the role played by the elusive hydronium ion in the transfer of protons during enzyme-catalyzed reactions.

Prior to this research, no one has ever directly witnessed the role of the hydronium ion, a water molecule bound to an additional hydrogen ion, in macromolecular catalyststhe catalytic mechanisms of enzymes.

Researchers took an interest in an enzyme that has the potential to allow conversion of sugars in woody biomass into alcohol, a potential alternative fuel, because the enzyme loses its effectiveness when the pH value of the milieu is lowereda common occurrence in the interior of industrial yeast cells fermenting alcohol. As it turns out, this biochemical reaction also has ramifications for the activation of proton pumps in the stomach, which produces excess acid in those afflicted by gastric diseases.

The scientists sought to figure out the mechanism behind these reactions. Neutrons from the Los Alamos Neutron Science Center provided a possible tool for unveiling the secret agent at the heart of the chemistry.

Hydronium ions had not been seen before by researchers who attempted to use X-rays to understand the chemical mechanism of enzymes. This is because tiny hydrogen atoms are essentially invisible under X-rays. To help make things visible, the researchers substituted hydrogen in their enzyme samples with deuterium, an isotope of hydrogen that behaves chemically identical to its nonisotopic counte
'/>"/>

Contact: James E. Rickman
jamesr@lanl.gov
505-665-9203
DOE/Los Alamos National Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. UGA researchers study threats to white sturgeon
2. Researchers gain new insights into how tumor cells are fed
3. University of Virginia researchers uncover new catalysis site
4. U of Minnesota researchers discover a natural food preservative that kills food-borne bacteria
5. Researchers develop fully cooked food-aid product
6. U of M researchers use improved imaging technique; discover a better approach to diagnosing epilepsy
7. RUB researchers decipher the molecular basis of blue-green algae
8. Researchers discover the mechanism that determines cell position in the intestinal epithelium
9. Caltech researchers increase the potency of HIV-battling proteins
10. Researchers tap yeasts as source of green surfactants
11. Lawson researchers take control of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... Fingerprint Cards, (FPC,s) new mobile touch sensor FPC1021 ... Top 5 smartphone OEM has selected FPC1021 for a flagship ... 2014.   FPC is proud to announce this ... a planned date for the start of mass production in ... of 3 million units. The Chinese OEM wants to remain ...
(Date:7/10/2014)... July 8, 2014 Fingerprint ... new design win (DW). An Asian OEM has selected FPC1021 ... production start in August 2014.   FPC is ... which has a planned date for start of mass production ... order of SEK 5M, for delivery in the first half ...
(Date:7/10/2014)... 9, 2014 The widespread adoption of ... part by meaningful use and related federal programs, ... with laboratory information. Now, more than ever, pathologists ... clinical informatics in order to deliver high quality ... the educational needs of pathologists in this evolving ...
Breaking Biology News(10 mins):FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2New Clinical Informatics Curriculum Prepares Future Pathologists 2New Clinical Informatics Curriculum Prepares Future Pathologists 3New Clinical Informatics Curriculum Prepares Future Pathologists 4
... release is available in French . ... a microscope. Now more than ever, municipal builders need to ... projects like the Turcot interchange lead Montrealers to wonder if ... New research from Concordia University gives us hope that this ...
... (Boston) A study led by researchers at Boston ... that connect a variety of diseases associated with inflammation. ... are cells largely responsible for inflammation, researchers have shown ... decrease the inflammatory response associated with diseases such as ...
... Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich identify a ... gene and prevents stress-induced neuronal cell death. ... and the second most common neurodegenerative disease after ... of dopamin-producing neurons in the substantia nigra, a ...
Cached Biology News:Towards more sustainable construction 2Mechanisms regulating inflammation associated with type 2 diabetes, cancer identified 2Parkinson's disease: Parkin protects from neuronal cell death 2
(Date:7/10/2014)... Deep Knowledge Ventures last week ... ‘Commercialising Longevity Research’ and welcomed a host of ... Bioscience Innovation Center for the event, organised by ... Ltd. The meeting highlighted the need for both ... age-related disease, as well as the crucial role ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been upgraded for ... a second treatment cup to help prevent and smooth skin ... thinner on the edges for a softer contact with the ... surfaces on the face, neck and décolleté. Choose to use ... such as the cheeks and neck, or opt for the ...
(Date:7/10/2014)... July 10, 2014 On July ... Medvedev , presented Russia,s first ... . The Company is developing a unique project called ... BIOCAD develops a number of innovative drugs based on ... The ceremony took place at the International Exhibition "Innoprom ...
Breaking Biology Technology:DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... Ron Van Beek, president and CEO of Van Beek ... for dogs and cats, available exclusively through veterinarians. ... supplement containing both probiotics and prebiotics that work together ... dog,s or cat,s GI tract.  Van Beek Natural Science,s ...
... Pharmaceuticals, Inc. (Nasdaq: AUXL ), a specialty biopharmaceutical ... year 2010 on Thursday, February 10, 2011 before the opening ... a conference call that day at 10:00 a.m. ET to ... year 2010.  The presentation slides to be used during the ...
... Barrow Neurological Institute scientist on the thermoregulatory effects of a ... the cover story in the Feb. 2 issue of the ... an international team led by Andrej Romanovsky, MD, PhD, Director ... a part of St. Joseph,s Hospital and Medical Center. ...
Cached Biology Technology:Van Beek Natural Science Announces New Synacore Digestive Support Product 2Auxilium Pharmaceuticals to Announce Fourth Quarter and Full Year 2010 Results and Conduct Conference Call on Thursday, February 10, 2011 2Auxilium Pharmaceuticals to Announce Fourth Quarter and Full Year 2010 Results and Conduct Conference Call on Thursday, February 10, 2011 3Auxilium Pharmaceuticals to Announce Fourth Quarter and Full Year 2010 Results and Conduct Conference Call on Thursday, February 10, 2011 4Barrow TRPV1 research highlighted in Journal of Neuroscience 2
mu Opioid Receptor splice variant Immunogen: Synthetic peptide corresponding to residues K S C M D R G M R N L L P D D G P R Q E of Mu Opioid Receptor. Storage: -20 C, Avoid Freeze/Thaw Cycle...
Anti-Salmonid Ig (H), Alk Phos, (Clone IPA5F12) (mouse IgG2a)...
Rat monoclonal [HK5.3] to B7 RP1 (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 23308 SwissProtID: O75144...
... UbcH7 interacts with the HECT ... RING domain. Evidence suggests that ... both the degradation of non-""N-end ... certain N-a -acetylated proteins as ...
Biology Products: