Navigation Links
Researchers use nanoscale 'patches' to sensitize targeted cell receptors
Date:11/25/2013

Researchers from North Carolina State University and Duke University have developed nanoscale "patches" that can be used to sensitize targeted cell receptors, making them more responsive to signals that control cell activity. The finding holds promise for promoting healing and facilitating tissue engineering research.

The research takes advantage of the fact that cells in a living organism can communicate via physical contact. Specifically, when targeted receptors on the surface of a cell are triggered, the cell receives instructions to alter its behavior in some way. For example, the instructions may cause a stem cell to differentiate into a bone cell or a cartilage cell.

These receptors respond to specific ligands, or target molecules. And those ligands have to be present in certain concentrations in order to trigger the receptors. If there aren't enough target ligands, the receptors won't respond.

Now researchers have developed nanoscale patches that are embedded with tiny protein fragments called peptides. These peptides bond to a specific cell receptor, making it more sensitive to its target ligand meaning that it takes fewer ligand molecules to trigger the receptor and its resulting behavior modification.

"This study shows that our concept can work, and there are a host of potential applications," says Dr. Thom LaBean, an associate professor of materials science at NC State and senior author of a paper describing the work. "For example, if we identify the relevant peptides, we could create patches that sensitize cells to promote cartilage growth on one side of the patch and bone growth on the other side. This could be used to expedite healing or to enable tissue engineering of biomedical implants."

"What's important about this is that it allows us to be extremely precise in controlling cell behavior and gene expression," says Ronnie Pedersen, a Ph.D. student at Duke University and lead author of the paper. "By
'/>"/>

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. 2 Cleveland Clinic researchers honored for contribution to science
2. Researchers describe 1 mechanism that favors rejection in transplantation of porcine cartilage in humans
3. UCLA, Emory researchers find a chemical signature for fast form of Parkinsons
4. Researchers map brain areas vital to understanding language
5. Researchers gain fuller picture of cell protein reactions
6. Scripps oceanography researchers engineer breakthrough for biofuel production
7. USF researchers show invasive sparrows immune cells sharpen as they spread
8. Researchers use CT and 3-D printers to recreate dinosaur fossils
9. Natural compound mitigates effects of methamphetamine abuse, University of Missouri researchers find
10. Researchers classify urban residential desert landscapes
11. Researchers test effects of LEDs on leaf lettuce
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... , Aug. 6, 2015 Synaptics ... of human interface solutions, today announced collaboration with ... on Windows 10. Microsoft leveraged Synaptics, deep expertise ... operating system. Through stringent testing, ... fully certified with Microsoft,s Precision TouchPad (PTP) specification ...
(Date:8/5/2015)... 5, 2015 Transparency Market Research ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... facial recognition is forecast to reach US$ 2,671.8 Mn ... for surveillance systems by civil and government agencies. This ... and terrorist activities across the globe that would elevate ...
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
Breaking Biology News(10 mins):Synaptics Chosen for Human Interface Co-Development on Windows 10 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... bumble bees are at risk, other bee species in ... despite expanding human populations and changing land use. Led ... from the American Museum of Natural History and nine ... at protecting native bee species and the important pollinator ...
... brain adds new cells during puberty to help navigate the ... report in the current issue of the Proceedings of ... think the brain cells you,re born with are all you ... in adults, conventional wisdom held that such growth was limited ...
... an additional 100.000 Euros in financial support , ... the financial support through the execution of the business ... the Building Global Innovators & continued financial support by ... Building Global Innovators Venture Competition. The seamless low-cost vehicle-based ...
Cached Biology News:New research confirms plight of bumble bees, persistence of other bees in Northeast 2Brain adds cells in puberty to navigate adult world 2Veniam is the winner of the major Portuguese Venture Competition 'Builidng Global Innovators' 2Veniam is the winner of the major Portuguese Venture Competition 'Builidng Global Innovators' 3Veniam is the winner of the major Portuguese Venture Competition 'Builidng Global Innovators' 4
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... Personalized Medicine, presented two studies at the International Spine Intervention Society’ ... 28th, 2015 through to August 1st, 2015. With a focus on evidence-based research ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... and orthopedic surgeon, Wade McKenna, DO, announced today that the use of sterile, ... resulted in complete healing of an otherwise non-healing surgical knee wound. , The ...
(Date:8/27/2015)... ... , ... Capital Edge Consulting , a nationwide consulting firm that specializes ... ranking as one of the top 5000 companies listed on the 2015 Inc. ... , “It is truly an honor to be recognized as one of America’s fastest ...
(Date:8/27/2015)... The National Necrotizing Fasciitis Foundation ... by doctors at Vanderbilt University Hospital in ... and Dr. John Crew , director of the ... Center in Daly City, CA. ... pioneered by Dr. Crew, that had previously saved the ...
Breaking Biology Technology:Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 2Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 4Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3
... No Child Should Die of Diabetes, BRUSSELS, October ... it is bringing together key opinion,leaders to push for ... diabetes in developing countries without access to care., ... in the,Developing World, will be held on Saturday, October ...
... Therapeutics is,presenting new data today representing an ... to enhance outcomes in patients,suffering from lower ... "Local Catheter-Directed Elastase Therapy: A Novel,Approach to ... at the 20th,annual Transcatheter Cardiovascular Therapeutics (TCT) ...
... risk of basal,cell carcinoma, and are integrated into ... Oct. 13 Scientists at,deCODE genetics (Nasdaq: ... of two single-letter variations in the human genome ... the most common cancer among,people of European ancestry. ...
Cached Biology Technology:International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 2International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 3Proteon Therapeutics to Present New Data on PRT-201 at Transcatheter Cardiovascular Therapeutics (TCT) Annual Symposium in Washington, D.C., October 13, 2008 2deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer 2deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer 3deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer 4
... N. Fernandez and G. Butcher (1998). ... subject of much research in the immunology ... structure of MHC proteins and in their ... are now faced with the prospect of ...
DALT GRADIENT MAKER,230V, 1 EA. Category: 2D DALT Systems....
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
Rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and refrigerated within 6 hours, and processed and frozen within 24 hours. The serum is ...
Biology Products: