Navigation Links
Researchers use nanoparticles to shrink tumors in mice
Date:7/9/2010

ound that MSNs circulate in the bloodstream for extended periods of time and accumulate predominantly in tumors. The tumor accumulation could be further improved by attaching a targeting moiety to MSNs, the researchers said.

The treatment of mice with camptothecin-loaded MSNs led to shrinkage and regression of xenograft tumors. By the end of the treatment, the mice were essentially tumor free, and acute and long-term toxicity of MSNs to the mice was negligible. Mice with breast cancer were used in this study, but the researchers have recently obtained similar results using mice with human pancreatic cancer.

"Our present study shows, for the first time, that MSNs are effective for anticancer drug delivery and that the capacity for tumor suppression is significant," Tamanoi said.

"Two properties of these nanoparticles are important," Lu said. "First, their ability to accumulate in tumors is excellent. They appear to evade the surveillance mechanism that normally removes materials foreign to the body. Second, most of the nanoparticles that were injected into the mice were excreted out through urine and feces within four days. The latter results are quite interesting and might explain the low toxicity observed in the biocompatabilty experiments we conducted."

Researchers at the Nano Machine Center for Targeted Delivery and On-Demand Release are modifying MSNs which are easily modifiable so that the nanoparticles can be equipped with nanomachines. For example, nanovalves are being attached at the opening of the pores to control the release of anticancer drugs. In addition, the interior of the pores is being modified so that the light-induced release of anticancer drugs can be achieved.

"We can modify both the particles themselves and also the attachments on the particles in a wide variety of ways, which makes this material particularly attractive for engineering drug-delivery vehicles," Zink said.

The
'/>"/>

Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
2. Researchers apply computing power to crack egg shell problem
3. Mount Sinai researchers discover new way diseases develop
4. Researchers develop drug delivery system using nanoparticles triggered by electromagnetic field
5. MSU researchers awarded $9.1 million grant to battle malaria in Malawi
6. Researchers calculate the cost of CO2 emissions, call for carbon tax
7. Researchers demystifying complex cellular communications hubs found in sensory neurons
8. Pitt researchers find new proteins that regulate blood pressure, flow
9. Rutgers researchers discover secrets of nutritious corn breed that withstands rigors of handling
10. Researchers discover trigger to early, effective antibody response
11. Hips dont lie: Researchers find more accurate technique to determine sex of skeletal remains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... to a fast food restaurant had a higher body ... from fast food, according to researchers at The University ... was particularly strong among those with a lower income. ... American Journal of Public Health indicates higher ... restaurant, and among lower-income African-Americans, the density, or number, ...
(Date:5/16/2013)... the cellular layer lining the body,s blood vessels, ... nanometers in thickness, this super-tenuous structure routinely withstands ... to create a unique and highly dynamic barrier ... from the body,s circulatory system. , It,s also ... be physically breached to enable immune cells ...
(Date:5/16/2013)... has discovered an ancient extinct creature with ,scissor hand-like, ... honour of his favourite movie star. , The ... (pronounced Koo-ten-ee-che-la depp-eye), which is a distant ancestor ... Johnny Depp for his starring role as Edward Scissorhands ... an unfinished creation, who has scissors for hands. ...
Breaking Biology News(10 mins):Body mass index of low income African-Americans linked to proximity of fast food restaurants 2Body mass index of low income African-Americans linked to proximity of fast food restaurants 3Endothelium, heal thyself 2Endothelium, heal thyself 3Endothelium, heal thyself 4Actor Johnny Depp immortalized in ancient fossil find 2
... long and very cold but the winter of 2009-2010 ... and the re-introduced wild Przewalski,s horse population crashed dramatically. ... Veterinary Medicine, Vienna have used spatially explicit loss statistics, ... into the effect of a catastrophic climate event on ...
... New research has found that elderly people with higher ... their blood had better performance on mental acuity tests and ... while "junk food" diets produced just the opposite result. ... specifically measure a wide range of blood nutrient levels instead ...
... research suggests that China,s impressive feat of cutting Beijing,s pollution ... some help from Mother Nature. Rain just at the beginning ... the effort needed to clean up the skies, scientists found. ... widely implemented than in 2008 if pollution levels are to ...
Cached Biology News:Don't put all your eggs in 1 basket -- or all your horses on 1 pasture 2Don't put all your eggs in 1 basket -- or all your horses on 1 pasture 3Diet, nutrient levels linked to cognitive ability, brain shrinkage 2Weather deserves medal for clean air during 2008 Olympics 2
(Date:5/16/2013)... , May 16, 2013  The registration deadline has ... Financial Officers (ABFO) 2013 National Conference, the premier conference ... May 28-31 at the Hilton San Diego Bayfront. ... this year,s conference and want to make sure as ... said Brandi Roberts , Chief Financial ...
(Date:5/16/2013)... FL (PRWEB) May 16, 2013 As the ... to showcase their favorite Spring looks. While most make a ... season. Unfortunately, many women find the warmer weather mixes makeup ... women cope with the onset of acne during warmer months, ... from female acne treatment users the best ways to deter ...
(Date:5/16/2013)... 16, 2013 Reportlinker.com announces ... is available in its catalogue: ... Analysis: Therapeutic Proteins – Biosimilars, Biobetters ...   Product ... The new Competitive Intelligence Report Therapeutic ...
(Date:5/16/2013)... BioInformatics LLC New Market Report – The ... and Future Opportunities (13-004) , With barriers to ... cells market continues to increase. In this study, BioInformatics ... how satisfied scientists are with commercially available primary cells, ... ,  , Additionally, terminally differentiated cells can be ...
Breaking Biology Technology:Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 2Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 3Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 4Adult Acne Treatment, Probiotic Action Shares New Tips for Women on How to Fight Acne While Wearing Makeup 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 5Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 6Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 7Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 8BioInformatics LLC New Market Report – The Market for Primary Cells & Stem Cell-Derived Cells: Current and Future Opportunities (13-004) 2BioInformatics LLC New Market Report – The Market for Primary Cells & Stem Cell-Derived Cells: Current and Future Opportunities (13-004) 3
... Mich., Jan. 23, 2012  A recent Van Andel Research Institute ... the molecular structure and function of an essential plant hormone ... and might ultimately lead to the development of new drugs ... builds on earlier work by the same team of investigators ...
... Jan. 23, 2012 Aethlon Medical, Inc. ... therapeutic filtration devices to address infectious disease, cancer ... has established an Extracorporeal Therapy Scientific Advisory Board ... and other therapies developed from the Aethlon ADAPT™ ...
... NEW YORK, Jan. 23, 2012   NeoStem, Inc. (NYSE ... international biopharmaceutical company with a focus on cell-based therapeutic development, ... for its PreSERVE Phase 2 clinical trial for ... infarction patients, and the President of its subsidiary, Progenitor ...
Cached Biology Technology:Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process 2Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 2Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 3Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 4Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 5Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 6Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 7Senior Management of NeoStem and Its Subsidiaries Invited to Speak at Seventh International Conference on Cell Therapy for Cardiovascular Disease 2Senior Management of NeoStem and Its Subsidiaries Invited to Speak at Seventh International Conference on Cell Therapy for Cardiovascular Disease 3Senior Management of NeoStem and Its Subsidiaries Invited to Speak at Seventh International Conference on Cell Therapy for Cardiovascular Disease 4
Request Info...
... in two product models - the 5000AT+ and ... that the 6000AT+ includes a membrane desolvation unit ... improved detection limits and reduced oxides. The Ultrasonic ... elements by 10-40 times. Note that with ICP-MS ...
... For potent inhibition of RNase A-type ... a protein of nonhuman origin that binds ... (e.g., RNase A, B, and C). It ... H, U1, U2, or CL3. QIAGEN RNase ...
... Ligands\n\nReceptor-related research has long been enabled by ... selected to keep pace with new discoveries. ... and services for receptor research and drug ... you do not find exactly what you ...
Biology Products: