Navigation Links
Researchers use nanoparticles to shrink tumors in mice
Date:7/9/2010

The application of nanotechnology in the field of drug delivery has attracted much attention in recent years. In cancer research, nanotechnology holds great promise for the development of targeted, localized delivery of anticancer drugs, in which only cancer cells are affected.

Such targeted-therapy methods would represent a major advance over current chemotherapy, in which anticancer drugs are distributed throughout the body, attacking healthy cells along with cancer cells and causing a number of adverse side effects.

By carrying out comprehensive studies on mice with human tumors, UCLA scientists have obtained results that move the research one step closer to this goal. In a paper published July 8 in the journal Small, researchers at UCLA's California NanoSystems Institute and Jonsson Comprehensive Cancer Center demonstrate that mesoporous silica nanoparticles (MSNs), tiny particles with thousands of pores, can store and deliver chemotherapeutic drugs in vivo and effectively suppress tumors in mice.

The researchers also showed that MSNs accumulate almost exclusively in tumors after administration and that the nanoparticles are excreted from the body after they have delivered their chemotherapeutic drugs.

The study was conducted jointly in the laboratories of Fuyu Tamanoi, a UCLA professor of microbiology, immunology and molecular genetics and director of the signal transduction and therapeutics program at UCLA's Jonsson Comprehensive Cancer Center, and Jeffrey Zink, a UCLA professor of chemistry and biochemistry. Tamanoi and Zink are researchers at the California NanoSystems Institute (CNSI) and are two of the co-directors of the CNSI's Nano Machine Center for Targeted Delivery and On-Demand Release. The lead investigator on the research is Jie Lu, a postdoctoral fellow in Tamanoi's lab. Monty Liong and Zongxi Li, researchers from Zink's lab, also contributed to this work.

In the study, researchers f
'/>"/>

Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
2. Researchers apply computing power to crack egg shell problem
3. Mount Sinai researchers discover new way diseases develop
4. Researchers develop drug delivery system using nanoparticles triggered by electromagnetic field
5. MSU researchers awarded $9.1 million grant to battle malaria in Malawi
6. Researchers calculate the cost of CO2 emissions, call for carbon tax
7. Researchers demystifying complex cellular communications hubs found in sensory neurons
8. Pitt researchers find new proteins that regulate blood pressure, flow
9. Rutgers researchers discover secrets of nutritious corn breed that withstands rigors of handling
10. Researchers discover trigger to early, effective antibody response
11. Hips dont lie: Researchers find more accurate technique to determine sex of skeletal remains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased emphasis ... investments in new testing and inspection technologies. The ... rise to a range of innovative test solutions. ... of Generation Y, which is generally more inclined ... result, product development strategies of test equipment vendors ...
(Date:12/4/2014)... Dec. 3, 2014  Crossmatch™, a leading provider ... its DigitalPersona ® Pro Enterprise software and ... deployed throughout First Bank branch locations in ... Carolina and Virginia. First Bank, a progressive ... Pines, North Carolina , selected the Crossmatch ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... de dezembro de  2012 A Integrated Biometrics, ... a certificação pelo FBI de sua novíssima tecnologia ... IB criou o novo produto usando a tecnologia ... com um transistor de película fina (TFT). A ...
... methodologies of identifying genes that contribute to the ... in several immune-system-related pathways contribute to development of ... 4 in the open-access journal PLOS ONE ... function in autism by integrating analysis of autism-associated ...
... and Cargill have renewed their partnership to eliminate lymphatic filariasis ... disease that affects over 2 million Haitians and is the ... is truly a national disease in Haiti and 87 percent ... of coastal Haiti, as much as half of the population ...
Cached Biology News:Integrated Biometrics Apresenta Sherlock, o Menor, Mais Leve e Fino Sensor Appendix F Mobile ID 2Combining two genome analysis approaches supports immune system contribution to autism 2Combining two genome analysis approaches supports immune system contribution to autism 3Cargill expands support of Notre Dame Haiti Program 2Cargill expands support of Notre Dame Haiti Program 3
(Date:12/24/2014)... Bethesda, MD (PRWEB) December 23, 2014 ... signed into law H.R. 83, the Omnibus and ... the first time, made hydrocephalus a condition eligible ... Research Programs (CDMRP) administered by the Department of ... conjunction with its allies on Capitol Hill, is ...
(Date:12/24/2014)... Diego, CA (PRWEB) December 23, 2014 ... where their Twitter followers can submit their #HolidayInTheLab ... themselves and their lab mates. , For those struggling ... lab mates, the Pipette.com Holiday in the Lab Contest ... Pipette.com Twitter followers to send pictures of ...
(Date:12/24/2014)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ) ... Application (CTA) with the United Kingdom,s ... approval to initiate clinical trials for the continued development ... on the Company receiving CTA regulatory approval, the Company ... the safety, tolerability and dose escalation of Anatabine Citrate ...
(Date:12/22/2014)... 22, 2014  Alternative Energy & Environmental Solutions, ... signed a letter of intent to acquire BioTechPharma ... patented a nanotechnology-based development platform used to create ... rapid on-site collection and testing to identify infectious ... in an immediate, non-invasive and cost-effective manner. ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3ALNE Announces Intention To Acquire BioTechPharma 2
... Feb. 6, 2012  BioStorage Technologies, a global provider ... cold chain logistics for the bioscience industry, will ... Partnerships in Clinical Trials on Tuesday, March 6, ... Florida.  The 2-hour workshop will ...
... Pa., Feb. 6, 2012  Auxilium Pharmaceuticals, Inc. (Nasdaq: ... today announced the appointment of two executive officers, ... Executive Vice President, Chief Administrative Officer and General ... Senior Vice President, Sales. "The leadership ...
... in Science , a Manchester team lead by Nobel ... opened a third dimension in graphene research. Their research shows ... to become the next silicon. Graphene one ... endless unique properties, from electronic to chemical and from optical ...
Cached Biology Technology:BioStorage Technologies to Host Global Sample Management Workshop at Partnerships in Clinical Trials 2Auxilium Announces Appointments to Enhance Leadership Team 2Auxilium Announces Appointments to Enhance Leadership Team 3Auxilium Announces Appointments to Enhance Leadership Team 4Auxilium Announces Appointments to Enhance Leadership Team 5Graphene electronics moves into a third dimension 2
Mouse monoclonal antibody raised against a full length recombinant SNAPC5. NCBI Entrez Gene ID = SNAPC5...
... raised against a partial recombinant NFKBIB. ... 145 a.a) partial recombinant protein with GST tag. ... Accession: BC015528 ... OMIM: 604495, GeneID: ...
... Perm/Wash Buffer I can be used in ... to permeabilize cells and to serve as ... Because saponin-mediated cell permeabilization is a reversible ... cells in the presence of saponin during ...
Mouse monoclonal antibody raised against a partial recombinant ACTN4. NCBI Entrez Gene ID = ACTN4...
Biology Products: