Navigation Links
Researchers use chemical from medicinal plants to fight HIV
Date:11/10/2008

a virus enters the body, the killer T-cells whose receptors recognize that virus create, through division, versions of themselves that fight the invader.

Generally, the telomeres in cells are sufficiently long that they can divide many times without a problem. Moreover, when fighting infections, T-cells can turn on an enzyme called telomerase, which can prevent the telomeres from shortening.

"The problem is that when we're dealing with a virus that can't be totally eliminated from the body, such as HIV, the T-cells fighting that virus can't keep their telomerase turned on forever," Effros said. "They turn off, and telomeres get shorter and they enter this stage of replicative senescence."

Previous studies have shown that injecting the telomerase gene into T-cells can keep the telomeres from shortening, enabling them to maintain their HIV-fighting function for much longer. This gene-therapy approach, however, is not a practical way to treat the millions of people living with HIV.

For the present study, rather than utilizing gene therapy, the researchers used a chemical called TAT2, which was originally identified from plants used in traditional Chinese therapy and which enhances telomerase activity in other cell types.

They tested TAT2 in several ways. First, they exposed the CD8 T-cells from HIV-infected persons to TAT2 to see if the chemical not only slowed the shortening of the telomeres but improved the cells' production of soluble factors called chemokines and cytokines, which had been previously shown to inhibit HIV replication. It did.

They then took blood samples from HIV-infected individuals and separated out the CD8 T-cells and the CD4 T-cells those infected with HIV. They treated the CD8 T-cells with TAT2 and combined them with the CD4 T-cells in the dish-and found that the treated CD8 cells inhibited production of HIV by the CD4 cells.

"The ability to enhance telomeras
'/>"/>

Contact: Enrique Rivero
erivero@mednet.ucla.edu
310-794-2273
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Yale researchers unravel mystery of brain aneurysms
2. Montana State University researchers find gene that regulates molds resistance to drugs
3. UC Davis researchers discover Achilles heel in pancreatic cancer
4. Repairing DNA damage: Researchers discover critical process in cancer treatment
5. Corn researchers discover novel gene shut-off mechanisms
6. Researchers at UH explore patient preferences for personalized medicine
7. UC Davis researchers discover a key to aggressive breast cancer
8. Caltech-led researchers find negative cues from appearance alone matter for real elections
9. ASU researchers receive NIH awards for studies of malaria and emergent disease
10. Stanford researchers: Global warming is killing frogs and salamanders in Yellowstone Park
11. Syracuse University researchers discover new way to attack some forms of leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Stem Cell scientists have set a "mouse TRAP" to ... by a recent study published in the Journal ... uses a technique called TRAP to extract cellular and ... Invented by scientists at the Rockefeller Institute for Medical ... to the protein-making machinery, or ribosomes, of the cell ...
(Date:7/11/2014)... often develop relationships with other group members to reduce ... chacma baboons the strategy for grooming activities shows a ... published in the scientific journal Biology Letters . ... is not practiced without ulterior motives. To be groomed ... individual, while grooming another individual can provide access to ...
(Date:7/11/2014)... The increased risk of kidney injury related to the ... the mass of HES molecules, according to a report ... the International Anesthesia Research Society (IARS). , The "total ... HES on cultured human renal proximal tubule cells (PTCs), ... colleagues of University Hospital Wrzburg, Austria. Other factorssuch ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... public divided about climate change because they don,t understand ... science and were more proficient in technical reasoning, would ... today online in the journal Nature Climate Change ... no. Indeed, as members of the public become more ...
... (RBC) is a critical component in the treatment ... problems. Indeed, approximately 75 million units of whole ... for processing and eventual transfusion. Despite this massive ... availability due to a combination of collection, manufacturing, ...
... the healthy growth of coral reefs in Hawaii may ... day treat human diseases, a new study led by ... Diego has revealed. An analysis led by Hyukjae ... Scripps, has shown that the seaweed, a tiny photosynthetic ...
Cached Biology News:Yale study concludes public apathy over climate change unrelated to science literacy 2Proteomic analysis of immunocamouflaged surfaces 2Nuisance seaweed found to produce compounds with biomedical potential 2
(Date:7/10/2014)... 2014 Terascala, the industry leader in ... Swahn, a former vice president of product management for ... president of marketing. Terascala’s software when combined with leading ... the highest performance and most reliable solutions for processing ... Terascala’s channel expansion and broaden its product portfolio. His ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 OMICS ... Bioanalytical techniques during 18-20 August, 2014 at Double Tree ... review the recent developments in Analytical & Bioanalytical research ... globe. , Speaking on this occasion, Dr. Srinubabu Gedela, ... Analytica Acta conference is a remarkable one in bringing ...
(Date:7/10/2014)... July 10, 2014  Franciscan St. Anthony ... capnography for respiratory monitoring outside the operating ... leaders in embracing state-of-the-art patient safety technology. ... are breathing and can alert medical caregivers ... the amount of carbon dioxide the patient ...
(Date:7/10/2014)... July 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, ... today announced an agreement with Lineagen, Inc., ... Lineagen,s NextStep Dx PLUS.  Lineagen, focused ... neurological disorders, currently offers FirstStep Dx ... service used by healthcare providers as a ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... SAIC-Frederick, Inc. and Biomatrica have begun ... which is becoming increasingly important in cancer research and ... therapies. The two organizations will focus on ... samples collected by pathologists in the clinic. Preserving nucleic ...
... be a magnet, and how can we control a magnet,s ... Igor Zutic, a theoretical physicist, has been exploring over many ... that magnets could revolutionize computing, forming the basis of high-capacity ... Today, in a commentary in Science , Zutic and ...
... Calif., May 26, 2011 MAP Pharmaceuticals, ... it has submitted a New Drug Application (NDA) to ... LEVADEX® orally inhaled migraine drug for the potential acute ... Headache Foundation, approximately 30 million people in the United ...
Cached Biology Technology:SAIC-Frederick and Biomatrica Collaborate to Improve Molecular Analysis in Cancer Research 2SAIC-Frederick and Biomatrica Collaborate to Improve Molecular Analysis in Cancer Research 3Chameleon magnets: Ability to switch magnets 'on' or 'off' could revolutionize computing 2Chameleon magnets: Ability to switch magnets 'on' or 'off' could revolutionize computing 3MAP Pharmaceuticals Submits New Drug Application to FDA for LEVADEX® Orally Inhaled Migraine Drug 2MAP Pharmaceuticals Submits New Drug Application to FDA for LEVADEX® Orally Inhaled Migraine Drug 3MAP Pharmaceuticals Submits New Drug Application to FDA for LEVADEX® Orally Inhaled Migraine Drug 4
... from BRAND adds ergonomics and ease-of-use ... only electronic, motor-driven repeating pipette compatible ... BRAND PD-Tip syringe tips, Eppendorf Combi-Tips ... VWRbrand Combi-Syringes. Select virtually any pipetting ...
The pYES2 vector is designed for native expression of your protein of interest in S. cerevisiae. It contains the URA3 gene for selection in yeast and 2 origin for high-copy maintenance....
Each 72-well MiniTray is low profile, with lid. Conical well shape, 10 l....
... synthase, cytoplasmic (C1-THF ... dehydrogenase (EC 1.5.1.5); ... 3.5.4.9); Formyltetrahydrofolate synthetase ... ...
Biology Products: