Navigation Links
Researchers unlock a new means of growing intestinal stem cells
Date:12/2/2013

CAMBRIDGE, MA -- Researchers at MIT and Brigham and Women's Hospital have shown that they can grow unlimited quantities of intestinal stem cells, then stimulate them to develop into nearly pure populations of different types of mature intestinal cells. Using these cells, scientists could develop and test new drugs to treat diseases such as ulcerative colitis.

The small intestine, like most other body tissues, has a small store of immature adult stem cells that can differentiate into more mature, specialized cell types. Until now, there has been no good way to grow large numbers of these stem cells, because they only remain immature while in contact with a type of supportive cells called Paneth cells.

In a new study appearing in the Dec. 1 online edition of Nature Methods, the researchers found a way to replace Paneth cells with two small molecules that maintain stem cells and promote their proliferation. Stem cells grown in a lab dish containing these molecules can stay immature indefinitely; by adding other molecules, including inhibitors and activators, the researchers can control what types of cells they eventually become.

"This opens the door to doing all kinds of things, ranging from someday engineering a new gut for patients with intestinal diseases to doing drug screening for safety and efficacy. It's really the first time this has been done," says Robert Langer, the David H. Koch Institute Professor, a member of MIT's Koch Institute for Integrative Cancer Research, and one of the paper's senior authors.

Jeffrey Karp, an associate professor of medicine at Harvard Medical School and Brigham and Women's Hospital, is also a senior author of the paper. The paper's lead author is Xiaolei Yin, a postdoc at the Koch Institute and Brigham and Women's Hospital.

From one cell, many

The inner layer of the intestines has several critical functions. Some cells are specialized to absorb nutrients from
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Colon cancer researchers target stem cells, discover viable new therapeutic path
2. Researchers find a missing component in effort to create primitive, synthetic cells
3. Researchers have a nose for how probiotics could affect hay fever
4. 4 Johns Hopkins researchers named AAAS Fellows
5. Researchers use nanoscale patches to sensitize targeted cell receptors
6. 2 Cleveland Clinic researchers honored for contribution to science
7. Researchers describe 1 mechanism that favors rejection in transplantation of porcine cartilage in humans
8. UCLA, Emory researchers find a chemical signature for fast form of Parkinsons
9. Researchers map brain areas vital to understanding language
10. Researchers gain fuller picture of cell protein reactions
11. Scripps oceanography researchers engineer breakthrough for biofuel production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/29/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ) ... Biomedical Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... America Biomedical Sensors market is estimated at $0.65 billion ... period 2014-2020 The near future will bring ... of each individual. These sensors can be set to ...
(Date:6/25/2015)...  TAKE Solutions Ltd., a global business technology solutions ... Patent and Trademark Office (USPTO) for its "Method for ... Clinical Accelerators to reduce the time taken to standardize ... without the accelerators), thus reducing time to market. ... the heart of the patented Clinical Data Standardization Process ...
(Date:6/24/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/hhwlfj/huawei_ascend ... "Huawei Ascend Mate 7 Fingerprint Sensor - Reverse ... Huawei,s technological choice for the fingerprint sensor ... and Samsung,s one. The Ascend Mate 7 presents ... a main actor in capacitive sensing human interface ...
Breaking Biology News(10 mins):Latin America Biomedical Sensors Market Report 2015-2020 2TAKE Solutions Awarded Patent By USPTO 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... Institute of Dental and Craniofacial Research (NIDCR), part of ... new piece to the puzzle of how tumor cells ... abnormal growth, a well-known process called angiogenesis. , As ... Cell, the scientists found that in addition to the ...
... for Clinical Pathology (ASCP) announced that the Society will ... to provide laboratory training and quality improvement programs in ... programs are for medical laboratory professionals in Africa and ... for AIDS Relief. , The funding comes ...
... in the brains of monkeys that assesses the level ... gained from experiments in which they gave the monkeys ... could give insights into why humans compulsively engage in ... overeating. , The researchers, Michael Platt and Allison McCoy, ...
Cached Biology News:New lead reported in tumor angiogenesis 2New lead reported in tumor angiogenesis 3Laboratory professionals in Africa receive training under AIDS Relief Plan 2Gambling monkeys give insight into neural machinery of risk 2Gambling monkeys give insight into neural machinery of risk 3Gambling monkeys give insight into neural machinery of risk 4
(Date:7/2/2015)... , July 2, 2015 ... Bio-tech procurement company Amici Procurement has chosen Microsoft ... help it move to Office 365.      ... provides small to medium-sized companies in the bio-tech sector ... aspects of the purchasing cycle to help them obtain ...
(Date:7/2/2015)... ... 2015 , ... In’Tech Medical SAS ( http://www.intech-medical.com ), a ... the acquisition of Turner Medical, Inc ., thus becoming a global leader ... Spine Industry. The acquisition of Turner Medical ideally supplements In’Tech Medical’s product offering, ...
(Date:7/1/2015)... and PARIS , ... AgBiome, and Genective, key developer of biotech crops, ... discovery of new generations of insect control traits. ... control to counter the realities of advancing insect ... aligning AgBiome,s unique insect control technology with Genective,s ...
(Date:7/1/2015)... ... 01, 2015 , ... The next-generation sequencing (NGS) clinical market is poised for ... diagnostics industry. BCC Research reveals in its new report that the market drivers of ... a growing need for better diagnostics as part of a molecular diagnostics trend. , ...
Breaking Biology Technology:Biotech Procurement Company Moves to Office 365 with iomart 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3AgBiome and Genective collaborate to create novel insect-resistant crops 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3
... ... Their shared efforts will begin in 2010 to benefit the West African country of ... Dallas, ... Understanding, Mercy Ships and MediSend International have formalized a partnership to help develop sustainable ...
... , , COLUMBUS, Ohio, Nov. 30 ... one of the nation,s first minority business early-stage capital summits. ... is called "Transforming the Landscape of Business in America: A ... including investors, national minority business leaders and local minority entrepreneurs. ...
... , NEW YORK, Nov. 30 The Michael J. Fox ... total awards to six research teams working to develop potentially ... the Novel Approaches to Drug Discovery for Parkinson,s Disease ... (NYSE: ELN ), a neuroscience-based biotechnology company. ...
Cached Biology Technology:Mercy Ships and MediSend International Partner to Deliver Hope and Healing 2Mercy Ships and MediSend International Partner to Deliver Hope and Healing 3Ohio Capital Fund Announces Sponsorship of Minority Business Conference 2The Michael J. Fox Foundation Announces $1.5 Million in Funding to Advance Development of Drug Targets for Disease-Modifying Parkinson's Disease Treatments 2The Michael J. Fox Foundation Announces $1.5 Million in Funding to Advance Development of Drug Targets for Disease-Modifying Parkinson's Disease Treatments 3
... Services is a microarray ... industrial and academic researchers. We ... of Agilent, and we provide ... Agilent catalogue arrays. Gene ...
Immunogen GST fusion protein corresponding to full-length rat JNK3/ SAPK1b. Quality Assurance Routinely evaluated by immunoblot. Stability 2 years at -20°C from date of shipment GenBank A...
... is a post-translational modification that plays ... including immune regulation, inflammation, cell-to-cell adhesion, ... developed two lectin based Glycoprotein Isolation ... Germ Agglutinin (WGA), that allow isolation ...
... The LS series of laser scanners is ... Expression Suite solution. ,Gene expression analysis, ... requirements essential to the advancement of ... rise to novel microarray formats and sizes. ...
Biology Products: