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Researchers uncover why the body can't defend against tuberculosis
Date:11/14/2011

ecome engulfed by macrophages, they secrete a protein named PtpA that disables the two separate mechanisms required for making the acidic environment that normally targets them. The end result is that Mtb lives comfortably in the immune cells, like a Trojan horse, hidden from the rest of the immune system. The bacteria then multiply inside the macrophage, and when released, they attack the body.

"We have been engaged in studying the interaction between the TB bacterium and the human macrophage over the past decade," says Dr. Av-Gay. "We are delighted with this discovery. Through learning about the tricks it uses, we now have new targets, so that we can develop better drugs against this devastating disease."

TB is the leading cause of death among infectious diseases in the world today and is responsible for one in four adult preventable deaths, according to the World Health Organization (WHO). Every 20 seconds TB kills someone, with approximately 4400 people dying every day. The WHO estimates that one-third of the world's population is infected.


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Contact: Lisa Carver
lisa.carver@vch.ca
604-875-4111 x61777
University of British Columbia
Source:Eurekalert

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