Navigation Links
Researchers uncover new evidence revealing molecular paths to autism
Date:10/29/2014

In the largest study of its kind to date, researchers have used DNA sequencing to uncover dozens of genes that heighten the risk for autism. Joseph Buxbaum, Ph.D., Icahn School of Medicine at Mount Sinai, New York City, Mark Daly, Ph.D., Broad Institute of Harvard and MIT, and their colleagues examined more than 14,000 DNA samples from affected children, parents and unrelated people. They identified changes in 107 genes that are likely to contribute to the risk for autism spectrum disorder (ASD) – a jump from the nine genes implicated in earlier studies using these approaches. The findings, reported online October 29, 2014, in Nature, provide a better understanding of some of the genetic and cellular changes in pathways and processes thought to be involved in ASD, and eventually may help lead to potential therapies. ASD, a complex disorder that affects one in 68 children in the United States, frequently affects a person's behavior and ability to interact with others.

The scientists identified variations and mutations in genes in three pathways that are important to normal development. In each case, the changes in these pathways were linked to autism risk. They include:

  • Synaptic function. Synapses are the spaces between nerve cells over which brain messages must travel. Mutations in synaptic genes and synapse formation and function can alter these messages.

  • Chromatin remodeling. DNA is packaged into chromatin in cells. Changes in this packaging can affect which genes are turned on and off, and the formation of neural connections in the brain.

  • Transcription. Instructions embedded in genes must be transcribed, or read, to build proteins, the workhorse of the cell. Transcription mistakes can affect a wide range of important processes in the brain, from controlling gene activity to transmitting messages.


'/>"/>

Contact: Steven Benowitz
steven.benowitz@nih.gov
301-451-8325
NIH/National Human Genome Research Institute
@genome_gov
Source:Eurekalert

Page: 1

Related biology news :

1. NUS researchers discover for the first time that a rare bush frog breeds in bamboo
2. Researchers look for the best way to help shake too much sodium
3. Researchers find why depression and aging linked to increased disease risk
4. Researchers look to exploit females natural resistance to infection
5. Oral drug reduces formation of precancerous polyps in the colon, UB researchers find
6. Researchers develop new cells meant to form blood vessels, treat peripheral artery disease
7. Bio researchers receive patent to fight superbugs
8. Researchers get $5.25 million to advance nuclear technologies in South Carolina
9. UT Arlington researchers develop new transparent nanoscintillators for radiation detection
10. BUSM researchers identify brain changes involved in alcohol-related sleep disturbances
11. USC researchers discover dual purpose of cancer drug in regulating expression of genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2020)... ... June 23, 2020 , ... ... antibody development services, today announced that the company has received ISO9001:2015 certification ... pharmaceutical, diagnostics, and research industries. The decision to pursue ISO9001 accreditation demonstrates ...
(Date:6/19/2020)... BOSTON (PRWEB) , ... June 16, 2020 , ... The ... Ph.D., is betting that if the stem cell medicine and pharmaceutical industries have easier ... their practice. So, starting July 5 of this year, Independence Day weekend in ...
(Date:6/11/2020)... ... June 09, 2020 , ... Superior Controls, Inc. , ... and IT solutions for the life sciences industry, is pleased to announce the recent ... out of the company’s Seabrook, New Hampshire office. In his new role, Boudreau ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 23, 2020 , ... Kerafast Inc. , ... today announced the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. ... studies of SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level ...
(Date:6/23/2020)... (PRWEB) , ... June 22, 2020 , ... ... now offering an Amniosomes special offer. This includes buy three, get the fourth ... call (888) 568-6909. , Amniotic derived exosomes, known as exosomes, have been a ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... today announced that it has filed an Investigational New Drug application (IND) with ... trial of its lead drug candidate NBTX-001 in patients with panic disorder (PD). ...
(Date:6/11/2020)... ... June 08, 2020 , ... ... platform delivered through the use of proprietary clean viral vectors, recently announced a ... United States. Greffex’s platform is the world’s most successful gene therapy delivery ...
Breaking Biology Technology: